E-ISSN 0976-2779 | ISSN 0975-8453
 

Review Article 


Spectrophotometric Determination of Mesalazine via Oxidative Coupling Reaction

Ahlam Ahmed Shehab, Dawood Habboo Muhammed.

Abstract
A simple and sensitive spectrophotometric method for the
determination of a mesalazine in the aqueous solution. The method is
based on the oxidative coupling reaction between mesalazine and
Phenothiazine in the presence of potassium dichromate as oxidizing
agent to forming a green color water soluble dye showing maximum
absorbance at 610nm. Beer’s law is obeyed in the concentration range
of (0.1-11) µg/ml, with Correlation confection (R2
) value more than
0.999.Molar absorptivity (2.055x10ā“) L.mole-1
.cm-1 and Sandall’s
sensitivity (0.007451) µg/cm2
. This method has been successfully
applied for the determination of mesalazine in various pharmaceutical
preparations.

Key words: Oxidative Coupling- Mesalazine- Phenothiazine


 
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Pubmed Style

Ahlam Ahmed Shehab, Dawood Habboo Muhammed. Spectrophotometric Determination of Mesalazine via Oxidative Coupling Reaction. SRP. 2020; 11(6): 922-929. doi:10.31838srp.2020.6.130


Web Style

Ahlam Ahmed Shehab, Dawood Habboo Muhammed. Spectrophotometric Determination of Mesalazine via Oxidative Coupling Reaction. http://www.sysrevpharm.org//?mno=10031 [Access: July 02, 2020]. doi:10.31838srp.2020.6.130


AMA (American Medical Association) Style

Ahlam Ahmed Shehab, Dawood Habboo Muhammed. Spectrophotometric Determination of Mesalazine via Oxidative Coupling Reaction. SRP. 2020; 11(6): 922-929. doi:10.31838srp.2020.6.130



Vancouver/ICMJE Style

Ahlam Ahmed Shehab, Dawood Habboo Muhammed. Spectrophotometric Determination of Mesalazine via Oxidative Coupling Reaction. SRP. (2020), [cited July 02, 2020]; 11(6): 922-929. doi:10.31838srp.2020.6.130



Harvard Style

Ahlam Ahmed Shehab, Dawood Habboo Muhammed (2020) Spectrophotometric Determination of Mesalazine via Oxidative Coupling Reaction. SRP, 11 (6), 922-929. doi:10.31838srp.2020.6.130



Turabian Style

Ahlam Ahmed Shehab, Dawood Habboo Muhammed. 2020. Spectrophotometric Determination of Mesalazine via Oxidative Coupling Reaction. Systematic Reviews in Pharmacy, 11 (6), 922-929. doi:10.31838srp.2020.6.130



Chicago Style

Ahlam Ahmed Shehab, Dawood Habboo Muhammed. "Spectrophotometric Determination of Mesalazine via Oxidative Coupling Reaction." Systematic Reviews in Pharmacy 11 (2020), 922-929. doi:10.31838srp.2020.6.130



MLA (The Modern Language Association) Style

Ahlam Ahmed Shehab, Dawood Habboo Muhammed. "Spectrophotometric Determination of Mesalazine via Oxidative Coupling Reaction." Systematic Reviews in Pharmacy 11.6 (2020), 922-929. Print. doi:10.31838srp.2020.6.130



APA (American Psychological Association) Style

Ahlam Ahmed Shehab, Dawood Habboo Muhammed (2020) Spectrophotometric Determination of Mesalazine via Oxidative Coupling Reaction. Systematic Reviews in Pharmacy, 11 (6), 922-929. doi:10.31838srp.2020.6.130





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