Abstract
Background: The menstrual cycle is a critical rhythm of life regulated by interactive levels of estradiol, progesterone, luteinizing hormones, and follicular stimulation, during this cycle several metabolic parameters fluctuate in conjunction with sex hormones, therefore, this work was performed to investigate whether the menstrual cycle in healthy women affects the liver and kidney function.
Materials and Methods: The study was conducted in the Faculty of Education for girls during the period October 2018–January 2019. It involved the participation of thirty healthy women with age between 18 and 26 years. All participants were non-smokers with no use of contraceptives or hormones. In addition, they confidently mentioned that they had had regular menstrual cycles (between 24 and 32 days).
Results: Our findings showed that the liver enzymes (ALT, AST and ALP) levels were higher in the luteal phase than their levels in the follicular phase (P≤ 0.05). However, there were no significant differences in the level of blood urea and serum creatinine between the two phases.
Conclusion: It can be concluded that the measurement of liver function test can be affected by the phases of menstrual cycle. It is important to take that into consideration when assessing the liver enzymes. It may also be of interest the potential beneficial effect endogenic E2 on liver enzymes.

Key words: Menstrual Cycles in healthy women, liver and kidney function.