E-ISSN 0976-2779 | ISSN 0975-8453
 

Review Article 


The Influence of Togetherness of Herpetic Virus infections on Cell Cycle Regulatory Gene Expressions in Sinonasal Malignancy

Marwa M. A. Jassim, Fakhria A. Al-Joufi, Majid M. Mahmood, Saad H. M. Ali, Gheed Matlub, Imad M. Al-Ani, Hassan A. Elgebaly, Ayman M. Mahmoud.

Abstract
The Epstein-Barr virus (EBV) is categorized as a human gamma-1 herpes-virus. The EBV infection can increase the risk of developing certain rare cancers such as sinonasal carcinomas (SNC). That due to the powerful ability of EBV to cause mutations in the cells and make cancerous changes in the tissues. The human cytomegalovirus (HCMV), mainly in tumor tissues, can target different types of cells. In addition, it can cause all hallmarks of cancerous changes in the tissues which is considered as a defining feature of these pathogens. The HCMV strictly exhibits both of cellular tumor-promoting and immune-evasive strategies as well. However, the p27(Kip1) protein, might contribute in many different signal transduction pathways and modulate the intermediate oncogenic roles in cancer. The p27(Kip1) protein combines with cyclin E-CDK2, cyclin A-CDK2, and cyclin D1-CDK4 forming complexes, resulting in preventing their activation. Mitogenic signals that cause reduction of p27 expression allow activation and progression of CDK/cyclin in the cell cycle. The p73 is a protein related to the p53 tumor protein; it considered as tumor suppressor that is significantly involved in the regulation of cell cycle and induction of apoptosis. This study aim at investigating the effect of both the HCMV and EBV infections on the gene expression of both p 27 and p73 in sinonasal carcinomas (SNC). The study involved eighteen (18) formalin-fixed, paraffin-embedded tissue blocks of sinonasal carcinomas (SNC). The verificatory re-examination for histopathological samples was done. The EBV-EBERs and HCMV-PP65 DNA localization detected by a Chromogenic In Situ Hybridization technique (CISH), while p27 and p73 gene product detected by immunohistochemistry technique (IHC). From the recent data, it is clear that the existence of those two viruses in SNC were at the highest range in poor different grades (45.5%). On the contrary, the co-expression rate of p27 and p73 genes were at elevated in poorly differentiated SNC tissues (73.5%).

Key words: SNC; EBV-EBERS; HCMV-PP65; CISH; IHC.


 
ARTICLE TOOLS
Abstract
PDF Fulltext
How to cite this articleHow to cite this article
Citation Tools
Related Records
 Articles by Marwa M. A. Jassim
Articles by Fakhria A. Al-Joufi
Articles by Majid M. Mahmood
Articles by Saad H. M. Ali
Articles by Gheed Matlub
Articles by Imad M. Al-Ani
Articles by Hassan A. Elgebaly
Articles by Ayman M. Mahmoud
on Google
on Google Scholar


How to Cite this Article
Pubmed Style

Marwa M. A. Jassim, Fakhria A. Al-Joufi, Majid M. Mahmood, Saad H. M. Ali, Gheed Matlub, Imad M. Al-Ani, Hassan A. Elgebaly, Ayman M. Mahmoud. The Influence of Togetherness of Herpetic Virus infections on Cell Cycle Regulatory Gene Expressions in Sinonasal Malignancy. SRP. 2021; 12(2): 159-164. doi:10.31838/srp.2021.2.19


Web Style

Marwa M. A. Jassim, Fakhria A. Al-Joufi, Majid M. Mahmood, Saad H. M. Ali, Gheed Matlub, Imad M. Al-Ani, Hassan A. Elgebaly, Ayman M. Mahmoud. The Influence of Togetherness of Herpetic Virus infections on Cell Cycle Regulatory Gene Expressions in Sinonasal Malignancy. http://www.sysrevpharm.org/?mno=10166 [Access: January 18, 2021]. doi:10.31838/srp.2021.2.19


AMA (American Medical Association) Style

Marwa M. A. Jassim, Fakhria A. Al-Joufi, Majid M. Mahmood, Saad H. M. Ali, Gheed Matlub, Imad M. Al-Ani, Hassan A. Elgebaly, Ayman M. Mahmoud. The Influence of Togetherness of Herpetic Virus infections on Cell Cycle Regulatory Gene Expressions in Sinonasal Malignancy. SRP. 2021; 12(2): 159-164. doi:10.31838/srp.2021.2.19



Vancouver/ICMJE Style

Marwa M. A. Jassim, Fakhria A. Al-Joufi, Majid M. Mahmood, Saad H. M. Ali, Gheed Matlub, Imad M. Al-Ani, Hassan A. Elgebaly, Ayman M. Mahmoud. The Influence of Togetherness of Herpetic Virus infections on Cell Cycle Regulatory Gene Expressions in Sinonasal Malignancy. SRP. (2021), [cited January 18, 2021]; 12(2): 159-164. doi:10.31838/srp.2021.2.19



Harvard Style

Marwa M. A. Jassim, Fakhria A. Al-Joufi, Majid M. Mahmood, Saad H. M. Ali, Gheed Matlub, Imad M. Al-Ani, Hassan A. Elgebaly, Ayman M. Mahmoud (2021) The Influence of Togetherness of Herpetic Virus infections on Cell Cycle Regulatory Gene Expressions in Sinonasal Malignancy. SRP, 12 (2), 159-164. doi:10.31838/srp.2021.2.19



Turabian Style

Marwa M. A. Jassim, Fakhria A. Al-Joufi, Majid M. Mahmood, Saad H. M. Ali, Gheed Matlub, Imad M. Al-Ani, Hassan A. Elgebaly, Ayman M. Mahmoud. 2021. The Influence of Togetherness of Herpetic Virus infections on Cell Cycle Regulatory Gene Expressions in Sinonasal Malignancy. Systematic Reviews in Pharmacy, 12 (2), 159-164. doi:10.31838/srp.2021.2.19



Chicago Style

Marwa M. A. Jassim, Fakhria A. Al-Joufi, Majid M. Mahmood, Saad H. M. Ali, Gheed Matlub, Imad M. Al-Ani, Hassan A. Elgebaly, Ayman M. Mahmoud. "The Influence of Togetherness of Herpetic Virus infections on Cell Cycle Regulatory Gene Expressions in Sinonasal Malignancy." Systematic Reviews in Pharmacy 12 (2021), 159-164. doi:10.31838/srp.2021.2.19



MLA (The Modern Language Association) Style

Marwa M. A. Jassim, Fakhria A. Al-Joufi, Majid M. Mahmood, Saad H. M. Ali, Gheed Matlub, Imad M. Al-Ani, Hassan A. Elgebaly, Ayman M. Mahmoud. "The Influence of Togetherness of Herpetic Virus infections on Cell Cycle Regulatory Gene Expressions in Sinonasal Malignancy." Systematic Reviews in Pharmacy 12.2 (2021), 159-164. Print. doi:10.31838/srp.2021.2.19



APA (American Psychological Association) Style

Marwa M. A. Jassim, Fakhria A. Al-Joufi, Majid M. Mahmood, Saad H. M. Ali, Gheed Matlub, Imad M. Al-Ani, Hassan A. Elgebaly, Ayman M. Mahmoud (2021) The Influence of Togetherness of Herpetic Virus infections on Cell Cycle Regulatory Gene Expressions in Sinonasal Malignancy. Systematic Reviews in Pharmacy, 12 (2), 159-164. doi:10.31838/srp.2021.2.19





Most Viewed Articles
  • Dental Development between Assisted Reproductive Therapy (Art) and Natural Conceived Children: A Comparative Pilot Study
    Norzaiti Mohd Kenali, Naimah Hasanah Mohd Fathil, Norbasyirah Bohari, Ahmad Faisal Ismail, Roszaman Ramli
    SRP. 2020; 11(1): 01-06
    » Abstract » doi: 10.5530/srp.2020.1.01

  • Psychometric properties of the World Health Organization Quality of life instrument, short form: Validity in the Vietnamese healthcare context
    Trung Quang Vo*, Bao Tran Thuy Tran, Ngan Thuy Nguyen, Tram ThiHuyen Nguyen, Thuy Phan Chung Tran
    SRP. 2020; 11(1): 14-22
    » Abstract » doi: 10.5530/srp.2020.1.03

  • A Prospective Review on Phyto-Pharmacological Aspects of Andrographis paniculata
    Govindraj Akilandeswari, Arumugam Vijaya Anand, Palanisamy Sampathkumar, Puthamohan Vinayaga Moorthi, Basavaraju Preethi
    SRP. 2019; 10(1): 15-19
    » Abstract » doi: 10.5530/srp.2019.1.3

  • A Review of Pharmacoeconomics: the key to “Healthcare for All”
    Hasamnis AA, Patil SS, Shaik Imam, Narendiran K
    SRP. 2019; 10(1): s40-s42
    » Abstract » doi: 10.5530/srp.2019.1s.21

  • Deuterium Depleted Water as an Adjuvant in Treatment of Cancer
    Anton Syroeshkin, Olga Levitskaya, Elena Uspenskaya, Tatiana Pleteneva, Daria Romaykina, Daria Ermakova
    SRP. 2019; 10(1): 112-117
    » Abstract » doi: 10.5530/srp.2019.1.19

  • Most Downloaded
  • Dental Development between Assisted Reproductive Therapy (Art) and Natural Conceived Children: A Comparative Pilot Study
    Norzaiti Mohd Kenali, Naimah Hasanah Mohd Fathil, Norbasyirah Bohari, Ahmad Faisal Ismail, Roszaman Ramli
    SRP. 2020; 11(1): 01-06
    » Abstract » doi: 10.5530/srp.2020.1.01

  • Manilkara zapota (L.) Royen Fruit Peel: A Phytochemical and Pharmacological Review
    Karle Pravin P, Dhawale Shashikant C
    SRP. 2019; 10(1): 11-14
    » Abstract » doi: 0.5530/srp.2019.1.2

  • Pharmacognostic and Phytopharmacological Overview on Bombax ceiba
    Pankaj Haribhau Chaudhary, Mukund Ganeshrao Tawar
    SRP. 2019; 10(1): 20-25
    » Abstract » doi: 10.5530/srp.2019.1.4

  • A Review of Pharmacoeconomics: the key to “Healthcare for All”
    Hasamnis AA, Patil SS, Shaik Imam, Narendiran K
    SRP. 2019; 10(1): s40-s42
    » Abstract » doi: 10.5530/srp.2019.1s.21

  • Psychometric properties of the World Health Organization Quality of life instrument, short form: Validity in the Vietnamese healthcare context
    Trung Quang Vo*, Bao Tran Thuy Tran, Ngan Thuy Nguyen, Tram ThiHuyen Nguyen, Thuy Phan Chung Tran
    SRP. 2020; 11(1): 14-22
    » Abstract » doi: 10.5530/srp.2020.1.03

  • Most Cited Articles