E-ISSN 0976-2779 | ISSN 0975-8453
 

Review Article 


Impact of Omega-3 on Hypercholesteremia Induced Male Rabbits

Fadhil A. Rizij, Ali M. Janabi, Ayad A. Ameen, Najah R. Hadi.

Abstract
Atherosclerosis is a disorder of vasculature wall resulting mainly from the inflammatory processes. This condition involves vascular endothelial dysfunction, recruitment and activation of phagocytic cells in early stages. Omega-3 polyunsaturated fatty acids comprise part of the cellular membrane function many roles including increased development and functionality of neuronal synapses. This study assesses the significance of omega-3 fatty acids on atherosclerosis events via lowering oxidative and inflammatory insults. In this study, twenty-four domestic rabbits (male) were randomly distributed into three groups. The first one was the negative control group in which, rabbits were received normal diet (Oxide) for twelve week-period. The second group was the hypercholesteremia-induced, untreated rabbits fed with cholesterol (1%) enriched diet. The third group consumed cholesterol (1%) enriched diet supplemented with 5% omega-3 fatty acids. Blood samples were collected after twelve weeks to measure high-density lipoprotein-C (HDL-C), total cholesterol (TC), serum triglycerides (TG), endothelin-1 (ET-1), intracellular adhesion molecule-1 (ICAM-1) and highly sensitive C-reactive protein (hs-CRP) levels. After twelve weeks, aorta of each rabbit was isolated to identify glutathione (GSH),malondialdehyde (MDA) and intimal thickness. Administration of omega-3 was un-capable to modify lipid parameters significantly when compared with high cholesterol-fed rabbits. Administration of omega-3 results in improvement of ICAM-1, hs-CRP, ET-1, aortic MDA and intimal thickness of aorta significantly when compared with untreated high cholesterol-fed rabbits (P<0.05), Aortic GSH level was restored in rabbits receiving omega-3 fatty acids (P<0.05). Omega-3 fatty acid may reduce atherosclerosis progression in high cholesterol-fed rabbits via suppression of inflammatory and oxidative cascades with the lack of impacting of lipid profile.

Key words: Omega 3 fatty acid, intracellular adhesion molecule-1, endothelin-1, aortic intimal thickness, oxidative stress, atherosclerosis.


 
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How to Cite this Article
Pubmed Style

Fadhil A. Rizij, Ali M. Janabi, Ayad A. Ameen, Najah R. Hadi. Impact of Omega-3 on Hypercholesteremia Induced Male Rabbits. SRP. 2020; 11(5): 70-74. doi:10.31838/srp.2020.5.12


Web Style

Fadhil A. Rizij, Ali M. Janabi, Ayad A. Ameen, Najah R. Hadi. Impact of Omega-3 on Hypercholesteremia Induced Male Rabbits. http://www.sysrevpharm.org//?mno=106837 [Access: May 31, 2020]. doi:10.31838/srp.2020.5.12


AMA (American Medical Association) Style

Fadhil A. Rizij, Ali M. Janabi, Ayad A. Ameen, Najah R. Hadi. Impact of Omega-3 on Hypercholesteremia Induced Male Rabbits. SRP. 2020; 11(5): 70-74. doi:10.31838/srp.2020.5.12



Vancouver/ICMJE Style

Fadhil A. Rizij, Ali M. Janabi, Ayad A. Ameen, Najah R. Hadi. Impact of Omega-3 on Hypercholesteremia Induced Male Rabbits. SRP. (2020), [cited May 31, 2020]; 11(5): 70-74. doi:10.31838/srp.2020.5.12



Harvard Style

Fadhil A. Rizij, Ali M. Janabi, Ayad A. Ameen, Najah R. Hadi (2020) Impact of Omega-3 on Hypercholesteremia Induced Male Rabbits. SRP, 11 (5), 70-74. doi:10.31838/srp.2020.5.12



Turabian Style

Fadhil A. Rizij, Ali M. Janabi, Ayad A. Ameen, Najah R. Hadi. 2020. Impact of Omega-3 on Hypercholesteremia Induced Male Rabbits. Systematic Reviews in Pharmacy, 11 (5), 70-74. doi:10.31838/srp.2020.5.12



Chicago Style

Fadhil A. Rizij, Ali M. Janabi, Ayad A. Ameen, Najah R. Hadi. "Impact of Omega-3 on Hypercholesteremia Induced Male Rabbits." Systematic Reviews in Pharmacy 11 (2020), 70-74. doi:10.31838/srp.2020.5.12



MLA (The Modern Language Association) Style

Fadhil A. Rizij, Ali M. Janabi, Ayad A. Ameen, Najah R. Hadi. "Impact of Omega-3 on Hypercholesteremia Induced Male Rabbits." Systematic Reviews in Pharmacy 11.5 (2020), 70-74. Print. doi:10.31838/srp.2020.5.12



APA (American Psychological Association) Style

Fadhil A. Rizij, Ali M. Janabi, Ayad A. Ameen, Najah R. Hadi (2020) Impact of Omega-3 on Hypercholesteremia Induced Male Rabbits. Systematic Reviews in Pharmacy, 11 (5), 70-74. doi:10.31838/srp.2020.5.12