E-ISSN 0976-2779 | ISSN 0975-8453
 

Review Article 


Anti- inflammatory and Anti- Arthritic Activity of Nanocurcumin in Albino Rats against Freund's Complete Adjuvant Induced- Arthritis

Zrar Saleem Kareem Almarzany.

Abstract
Goal: The inquiry intended to examine the potency of nanocurcumin (NC) at inhibiting FCA- persuaded osteoarthritis.
Methods: Rats selected randomly dispersed within three cohorts: (𝑛 = 6/group): healthy key group, osteoarthritis group (Urged with a single intradermal 0.1 ml FCA injection) and arthritis group received daily uttered gavage of 100 mg/kg of nanocurcumin for one month. haematological parameters as haemoglobin (Hb) scale, red blood cell count (RBC), white blood cell count (WBC), the erythrocyte sedimentation rate (ESR), C-reactive protein scale (CRP) and interleukin-10(IL-10) level were measured. Bone marrow smear was done to count bone marrow differential cells.
Results: The result of this study revealed that the changed haematological parameters and IL-10 in the arthritic rats were returned back generally to akin standard by the Nanocurcumin therapy at a dose 100mg/kg. Arthritis group treated with Nanocurcumin improve process of haematopoiesis in bone marrow.
Conclusion: In conclusion, based on the current study results, we suggest therapeutic effect of Nanocurcumin against FCA- caused osteoarthritis in albino rats. Nanocurcumin alleviates rheumatoid arthritis-induced inflammation.

Key words: arthritis, Nanocurcumin, Hematology, Bone marrow cells, interleukin 10.


 
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Pubmed Style

Zrar Saleem Kareem Almarzany. Anti- inflammatory and Anti- Arthritic Activity of Nanocurcumin in Albino Rats against Freund's Complete Adjuvant Induced- Arthritis. SRP. 2020; 11(5): 98-105. doi:10.31838/srp.2020.5.16


Web Style

Zrar Saleem Kareem Almarzany. Anti- inflammatory and Anti- Arthritic Activity of Nanocurcumin in Albino Rats against Freund's Complete Adjuvant Induced- Arthritis. http://www.sysrevpharm.org//?mno=107635 [Access: May 31, 2020]. doi:10.31838/srp.2020.5.16


AMA (American Medical Association) Style

Zrar Saleem Kareem Almarzany. Anti- inflammatory and Anti- Arthritic Activity of Nanocurcumin in Albino Rats against Freund's Complete Adjuvant Induced- Arthritis. SRP. 2020; 11(5): 98-105. doi:10.31838/srp.2020.5.16



Vancouver/ICMJE Style

Zrar Saleem Kareem Almarzany. Anti- inflammatory and Anti- Arthritic Activity of Nanocurcumin in Albino Rats against Freund's Complete Adjuvant Induced- Arthritis. SRP. (2020), [cited May 31, 2020]; 11(5): 98-105. doi:10.31838/srp.2020.5.16



Harvard Style

Zrar Saleem Kareem Almarzany (2020) Anti- inflammatory and Anti- Arthritic Activity of Nanocurcumin in Albino Rats against Freund's Complete Adjuvant Induced- Arthritis. SRP, 11 (5), 98-105. doi:10.31838/srp.2020.5.16



Turabian Style

Zrar Saleem Kareem Almarzany. 2020. Anti- inflammatory and Anti- Arthritic Activity of Nanocurcumin in Albino Rats against Freund's Complete Adjuvant Induced- Arthritis. Systematic Reviews in Pharmacy, 11 (5), 98-105. doi:10.31838/srp.2020.5.16



Chicago Style

Zrar Saleem Kareem Almarzany. "Anti- inflammatory and Anti- Arthritic Activity of Nanocurcumin in Albino Rats against Freund's Complete Adjuvant Induced- Arthritis." Systematic Reviews in Pharmacy 11 (2020), 98-105. doi:10.31838/srp.2020.5.16



MLA (The Modern Language Association) Style

Zrar Saleem Kareem Almarzany. "Anti- inflammatory and Anti- Arthritic Activity of Nanocurcumin in Albino Rats against Freund's Complete Adjuvant Induced- Arthritis." Systematic Reviews in Pharmacy 11.5 (2020), 98-105. Print. doi:10.31838/srp.2020.5.16



APA (American Psychological Association) Style

Zrar Saleem Kareem Almarzany (2020) Anti- inflammatory and Anti- Arthritic Activity of Nanocurcumin in Albino Rats against Freund's Complete Adjuvant Induced- Arthritis. Systematic Reviews in Pharmacy, 11 (5), 98-105. doi:10.31838/srp.2020.5.16