E-ISSN 0976-2779 | ISSN 0975-8453
 

Review Article 


The Role of Lymph-vascular Space Invasion towards Disease of Free Survival and Overall Survival Cancer in High-Risk Endometrial Cancer Endometrioid Type Patients

Brahmana Askandar Tjokroprawiro, Trianggono Bagus Ariyanto, Indra Yuliati, Willy Sandhika.

Abstract
Major prognostic factors of endometrial cancer include stage, age, histopathological type, grading, depth of invasion of myometrium, and presence of Lymph-vascular Space Invasion (LVSI). This study evaluated the LVSI in disease free survival (DFS) and overall survival (OS) in high-risk endometrial cancer endometrioid type. This was a retrospective study. Survival analysis using Kaplan-Maier curve, log rank test, cox-regression and logistic regression were used to determine effects among variables. Among fifty-six patients, 43% of patients were <60 years, 73% with BMI <30, 17% were multiparous, and 79% were menopausal patients. There were 32% of patients with positive LVSI. Most clinical stages were found in stage III with 31 cases (55%). Patients with positive LVSI had OS lower than patients with negative LVSI (50% vs 55.3%). There were no significant results of LVSI as prognostic factor for OS. Patients with LVSI positive had survival time of 26.5 months (20.5 32.5). There were no significant results of LVSI as prognostic factor for DFS. Patients with positive LVSI had lower DFS than patients with negative LVSI (81.8% vs 85.7%). There were significant results of LVSI as prognostic factor for high-risk endometrioid type endometrial cancer with stage endometrial cancer with p = 0.01. LVSI acts as prognostic factor for high-risk endometrioid type endometrial cancer associated with stage endometrial cancer. However, there was no effect in DFS and OS.

Key words: Endometrial cancer, LVSI, disease free survival, overall survival


 
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How to Cite this Article
Pubmed Style

Brahmana Askandar Tjokroprawiro, Trianggono Bagus Ariyanto, Indra Yuliati, Willy Sandhika. The Role of Lymph-vascular Space Invasion towards Disease of Free Survival and Overall Survival Cancer in High-Risk Endometrial Cancer Endometrioid Type Patients. SRP. 2020; 11(5): 176-180. doi:10.31838/srp.2020.5.26


Web Style

Brahmana Askandar Tjokroprawiro, Trianggono Bagus Ariyanto, Indra Yuliati, Willy Sandhika. The Role of Lymph-vascular Space Invasion towards Disease of Free Survival and Overall Survival Cancer in High-Risk Endometrial Cancer Endometrioid Type Patients. http://www.sysrevpharm.org//?mno=108403 [Access: May 31, 2020]. doi:10.31838/srp.2020.5.26


AMA (American Medical Association) Style

Brahmana Askandar Tjokroprawiro, Trianggono Bagus Ariyanto, Indra Yuliati, Willy Sandhika. The Role of Lymph-vascular Space Invasion towards Disease of Free Survival and Overall Survival Cancer in High-Risk Endometrial Cancer Endometrioid Type Patients. SRP. 2020; 11(5): 176-180. doi:10.31838/srp.2020.5.26



Vancouver/ICMJE Style

Brahmana Askandar Tjokroprawiro, Trianggono Bagus Ariyanto, Indra Yuliati, Willy Sandhika. The Role of Lymph-vascular Space Invasion towards Disease of Free Survival and Overall Survival Cancer in High-Risk Endometrial Cancer Endometrioid Type Patients. SRP. (2020), [cited May 31, 2020]; 11(5): 176-180. doi:10.31838/srp.2020.5.26



Harvard Style

Brahmana Askandar Tjokroprawiro, Trianggono Bagus Ariyanto, Indra Yuliati, Willy Sandhika (2020) The Role of Lymph-vascular Space Invasion towards Disease of Free Survival and Overall Survival Cancer in High-Risk Endometrial Cancer Endometrioid Type Patients. SRP, 11 (5), 176-180. doi:10.31838/srp.2020.5.26



Turabian Style

Brahmana Askandar Tjokroprawiro, Trianggono Bagus Ariyanto, Indra Yuliati, Willy Sandhika. 2020. The Role of Lymph-vascular Space Invasion towards Disease of Free Survival and Overall Survival Cancer in High-Risk Endometrial Cancer Endometrioid Type Patients. Systematic Reviews in Pharmacy, 11 (5), 176-180. doi:10.31838/srp.2020.5.26



Chicago Style

Brahmana Askandar Tjokroprawiro, Trianggono Bagus Ariyanto, Indra Yuliati, Willy Sandhika. "The Role of Lymph-vascular Space Invasion towards Disease of Free Survival and Overall Survival Cancer in High-Risk Endometrial Cancer Endometrioid Type Patients." Systematic Reviews in Pharmacy 11 (2020), 176-180. doi:10.31838/srp.2020.5.26



MLA (The Modern Language Association) Style

Brahmana Askandar Tjokroprawiro, Trianggono Bagus Ariyanto, Indra Yuliati, Willy Sandhika. "The Role of Lymph-vascular Space Invasion towards Disease of Free Survival and Overall Survival Cancer in High-Risk Endometrial Cancer Endometrioid Type Patients." Systematic Reviews in Pharmacy 11.5 (2020), 176-180. Print. doi:10.31838/srp.2020.5.26



APA (American Psychological Association) Style

Brahmana Askandar Tjokroprawiro, Trianggono Bagus Ariyanto, Indra Yuliati, Willy Sandhika (2020) The Role of Lymph-vascular Space Invasion towards Disease of Free Survival and Overall Survival Cancer in High-Risk Endometrial Cancer Endometrioid Type Patients. Systematic Reviews in Pharmacy, 11 (5), 176-180. doi:10.31838/srp.2020.5.26