E-ISSN 0976-2779 | ISSN 0975-8453
 

Review Article 


Antimicrobial and Antibiofilm Activity of D-amino acids Combined with Nanoparticles against Candida albicans

Saif Talib Jasim, Asoda Mohammed Noori, Shadman Tariq Sadiq, May Talib Flayyih.

Abstract
For the examined acids of D-amino, our findings indicated that D- aspartic (D-asp) acid was of high antifungal potentential, and then D-glycine. Also, the current study aimed to determine the effects of D-amino acids and nanoparticles against Candida albicans adhered cells and biofilms, results illustrated the D-asp concentration of 50 μg /ml caused inhibition as the highest, whereas the least was of D-gly 100 μg /ml of against mature bio-film cell adhesion and. The results proved that the combination of amino acid (D-glycine and D-aspartic acid) and nanoparticles (silver and lithium) at sub MIC concentrations (p≤0.05) inhibited cell adhesion and mature biofilm. Scanning electron microscope (SEM) results in observing the structure consisted of biofilm isolate C.albicans revealed, whereas therapy of D-asp had aneffect on bio-film layers of more losing loss in the layers merged of bio-film and destroyed it. On the other hand, merged lithium along the D-asp effect destroyed cells and caused the bio-film single layer survival.

Key words: D-aminoacids, antifungal, antimicrobial, nanoparticles, C.albicans.


 
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How to Cite this Article
Pubmed Style

Saif Talib Jasim, Asoda Mohammed Noori, Shadman Tariq Sadiq, May Talib Flayyih. Antimicrobial and Antibiofilm Activity of D-amino acids Combined with Nanoparticles against Candida albicans. SRP. 2020; 11(5): 274-280. doi:10.31838/srp.2020.5.40


Web Style

Saif Talib Jasim, Asoda Mohammed Noori, Shadman Tariq Sadiq, May Talib Flayyih. Antimicrobial and Antibiofilm Activity of D-amino acids Combined with Nanoparticles against Candida albicans. http://www.sysrevpharm.org//?mno=108690 [Access: May 31, 2020]. doi:10.31838/srp.2020.5.40


AMA (American Medical Association) Style

Saif Talib Jasim, Asoda Mohammed Noori, Shadman Tariq Sadiq, May Talib Flayyih. Antimicrobial and Antibiofilm Activity of D-amino acids Combined with Nanoparticles against Candida albicans. SRP. 2020; 11(5): 274-280. doi:10.31838/srp.2020.5.40



Vancouver/ICMJE Style

Saif Talib Jasim, Asoda Mohammed Noori, Shadman Tariq Sadiq, May Talib Flayyih. Antimicrobial and Antibiofilm Activity of D-amino acids Combined with Nanoparticles against Candida albicans. SRP. (2020), [cited May 31, 2020]; 11(5): 274-280. doi:10.31838/srp.2020.5.40



Harvard Style

Saif Talib Jasim, Asoda Mohammed Noori, Shadman Tariq Sadiq, May Talib Flayyih (2020) Antimicrobial and Antibiofilm Activity of D-amino acids Combined with Nanoparticles against Candida albicans. SRP, 11 (5), 274-280. doi:10.31838/srp.2020.5.40



Turabian Style

Saif Talib Jasim, Asoda Mohammed Noori, Shadman Tariq Sadiq, May Talib Flayyih. 2020. Antimicrobial and Antibiofilm Activity of D-amino acids Combined with Nanoparticles against Candida albicans. Systematic Reviews in Pharmacy, 11 (5), 274-280. doi:10.31838/srp.2020.5.40



Chicago Style

Saif Talib Jasim, Asoda Mohammed Noori, Shadman Tariq Sadiq, May Talib Flayyih. "Antimicrobial and Antibiofilm Activity of D-amino acids Combined with Nanoparticles against Candida albicans." Systematic Reviews in Pharmacy 11 (2020), 274-280. doi:10.31838/srp.2020.5.40



MLA (The Modern Language Association) Style

Saif Talib Jasim, Asoda Mohammed Noori, Shadman Tariq Sadiq, May Talib Flayyih. "Antimicrobial and Antibiofilm Activity of D-amino acids Combined with Nanoparticles against Candida albicans." Systematic Reviews in Pharmacy 11.5 (2020), 274-280. Print. doi:10.31838/srp.2020.5.40



APA (American Psychological Association) Style

Saif Talib Jasim, Asoda Mohammed Noori, Shadman Tariq Sadiq, May Talib Flayyih (2020) Antimicrobial and Antibiofilm Activity of D-amino acids Combined with Nanoparticles against Candida albicans. Systematic Reviews in Pharmacy, 11 (5), 274-280. doi:10.31838/srp.2020.5.40