E-ISSN 0976-2779 | ISSN 0975-8453
 

Review Article 


The Association between a Genetic Polymorphism in the Promoter Region of the CYP17 Gene and Sebum Level on Acne Vulgaris

Evi Mustikawati Arifin, Syafruddin Amin, Anis Irawan Anwar, Budu, Burhanuddin Bahar, Muh. Nasrum Massi, Huldani, Sri Ramadhany, Marhamah F. Singgih.

Abstract
Introduction: Generally Acne vulgaris (AV) is considered as a multifactorial disease, and many arguments have been raised on the role of heredity in the etiology of acne, the relevant genetic elements in the pathogenesis of the disease are not well established.
Objective: The aim of our study was to explore the association between a genetic polymorphism in the promoter region of the CYP17 gene and sebum level on mild and severe the development of acne patients.
Methods: There were total 43 samples, consisted of 22 severe AV and 21 mild AV patients. sebum level were measured using Sebumeter. Blood samples were taken from all patients as much as 1 L. Polymerase Chain Reaction-Sequencing (PCR- sequencing) was used to detect existence of CYP17 gene polymorphism, genome group was observed and the results of the genotype and allele frequencies were compared with sebum level. genotype distribution group was compared with previous researches.
Results: Proportion of T gene CYP17 allele frequency is higher than alel C, indicated that T gene CYP17 allele may serve as a risk factor for severe AV cases in Makassar. The genotype frequency towards increase of sebum level revealed that TC is two times larger than TT genotype and five times larger than CC genotype.
Conclusion: The study shows that polymorphisms of CYP 17 gene and the interaction polimorphisms of CYP 17 gene was considered as a risk factor for higher sebum level.

Key words: Acne vulgaris, Gene CYP17 Polymorphism, Sebum level


 
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How to Cite this Article
Pubmed Style

Evi Mustikawati Arifin, Syafruddin Amin, Anis Irawan Anwar, Budu, Burhanuddin Bahar, Muh. Nasrum Massi, Huldani, Sri Ramadhany, Marhamah F. Singgih. The Association between a Genetic Polymorphism in the Promoter Region of the CYP17 Gene and Sebum Level on Acne Vulgaris. SRP. 2020; 11(5): 288-292. doi:10.31838/srp.2020.5.42


Web Style

Evi Mustikawati Arifin, Syafruddin Amin, Anis Irawan Anwar, Budu, Burhanuddin Bahar, Muh. Nasrum Massi, Huldani, Sri Ramadhany, Marhamah F. Singgih. The Association between a Genetic Polymorphism in the Promoter Region of the CYP17 Gene and Sebum Level on Acne Vulgaris. http://www.sysrevpharm.org//?mno=108718 [Access: May 31, 2020]. doi:10.31838/srp.2020.5.42


AMA (American Medical Association) Style

Evi Mustikawati Arifin, Syafruddin Amin, Anis Irawan Anwar, Budu, Burhanuddin Bahar, Muh. Nasrum Massi, Huldani, Sri Ramadhany, Marhamah F. Singgih. The Association between a Genetic Polymorphism in the Promoter Region of the CYP17 Gene and Sebum Level on Acne Vulgaris. SRP. 2020; 11(5): 288-292. doi:10.31838/srp.2020.5.42



Vancouver/ICMJE Style

Evi Mustikawati Arifin, Syafruddin Amin, Anis Irawan Anwar, Budu, Burhanuddin Bahar, Muh. Nasrum Massi, Huldani, Sri Ramadhany, Marhamah F. Singgih. The Association between a Genetic Polymorphism in the Promoter Region of the CYP17 Gene and Sebum Level on Acne Vulgaris. SRP. (2020), [cited May 31, 2020]; 11(5): 288-292. doi:10.31838/srp.2020.5.42



Harvard Style

Evi Mustikawati Arifin, Syafruddin Amin, Anis Irawan Anwar, Budu, Burhanuddin Bahar, Muh. Nasrum Massi, Huldani, Sri Ramadhany, Marhamah F. Singgih (2020) The Association between a Genetic Polymorphism in the Promoter Region of the CYP17 Gene and Sebum Level on Acne Vulgaris. SRP, 11 (5), 288-292. doi:10.31838/srp.2020.5.42



Turabian Style

Evi Mustikawati Arifin, Syafruddin Amin, Anis Irawan Anwar, Budu, Burhanuddin Bahar, Muh. Nasrum Massi, Huldani, Sri Ramadhany, Marhamah F. Singgih. 2020. The Association between a Genetic Polymorphism in the Promoter Region of the CYP17 Gene and Sebum Level on Acne Vulgaris. Systematic Reviews in Pharmacy, 11 (5), 288-292. doi:10.31838/srp.2020.5.42



Chicago Style

Evi Mustikawati Arifin, Syafruddin Amin, Anis Irawan Anwar, Budu, Burhanuddin Bahar, Muh. Nasrum Massi, Huldani, Sri Ramadhany, Marhamah F. Singgih. "The Association between a Genetic Polymorphism in the Promoter Region of the CYP17 Gene and Sebum Level on Acne Vulgaris." Systematic Reviews in Pharmacy 11 (2020), 288-292. doi:10.31838/srp.2020.5.42



MLA (The Modern Language Association) Style

Evi Mustikawati Arifin, Syafruddin Amin, Anis Irawan Anwar, Budu, Burhanuddin Bahar, Muh. Nasrum Massi, Huldani, Sri Ramadhany, Marhamah F. Singgih. "The Association between a Genetic Polymorphism in the Promoter Region of the CYP17 Gene and Sebum Level on Acne Vulgaris." Systematic Reviews in Pharmacy 11.5 (2020), 288-292. Print. doi:10.31838/srp.2020.5.42



APA (American Psychological Association) Style

Evi Mustikawati Arifin, Syafruddin Amin, Anis Irawan Anwar, Budu, Burhanuddin Bahar, Muh. Nasrum Massi, Huldani, Sri Ramadhany, Marhamah F. Singgih (2020) The Association between a Genetic Polymorphism in the Promoter Region of the CYP17 Gene and Sebum Level on Acne Vulgaris. Systematic Reviews in Pharmacy, 11 (5), 288-292. doi:10.31838/srp.2020.5.42