E-ISSN 0976-2779 | ISSN 0975-8453
 

Review Article 


The Role of Polymorphism of Hereditary Thrombophilia Candidate Genes in the Development of Arterial Hypertension in Women with Preeclampsia.

Oleg V. Golovchenko, Maria Yu. Abramova, Oksana B. Altukhova, Irina N. Verzilina, Natalya A. Rudyh, Vladimir F. Kulikovsky.

Abstract
Preeclampsia is a severe pregnancy complication that has long been one of the leading causes of maternal and perinatal mortality and morbidity worldwide. Despite the achievements of modern medicine, the etiology of this pathology is not known. Multiple risk factors for the development of PE have been identified: arterial hypertension, diabetes mellitus, obesity, a hereditary history of preeclampsia, thrombophilia, etc., but recently, special attention has been paid to genetic determinants, namely, the contribution of individual polymorphic loci of various genes. In the course of our study, we studied the contribution of the rs5918 and rs1126643 polymorphisms of the GPIII and ITGA2 gene, respectively, associated with the development of hereditary thrombophilia, in the development of arterial hypertension, as one of the main symptoms of preeclampsia. The sample included 455 patients with PE; the average age of women was 26.41  4.92 years. It was found that women with PE with CC genotype of rs5918 polymorphism of the GPIIIa gene had a more pronounced increase in blood pressure indicators (the distribution of CC, CT, and TT genotypes was 2.25% (n=10), 25.68% (n=114), 72.07% (n=320)), and with the TT genotype of polymorphism rs1126643 of the ITGA2 gene, a more pronounced increase in SBP and DBP was observed (the frequency of TT, CT genotypes is 19.06% (n=85), 48.43% (n=216), 32.51% (n=145 ) respectively). Thus, it was found that the CC rs5918 genotypes of the GPIII gene and TT rs1126643 of the ITGA2 gene are associated with a more pronounced increase in blood pressure in women with pre-eclampsia by the end of pregnancy.

Key words: preeclampsia, arterial hypertension, hereditary thrombophilia, rs5918, rs1126643.


 
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How to Cite this Article
Pubmed Style

Oleg V. Golovchenko, Maria Yu. Abramova, Oksana B. Altukhova, Irina N. Verzilina, Natalya A. Rudyh, Vladimir F. Kulikovsky. The Role of Polymorphism of Hereditary Thrombophilia Candidate Genes in the Development of Arterial Hypertension in Women with Preeclampsia.. SRP. 2020; 11(6): 11-15. doi:10.31838/srp.2020.6.03


Web Style

Oleg V. Golovchenko, Maria Yu. Abramova, Oksana B. Altukhova, Irina N. Verzilina, Natalya A. Rudyh, Vladimir F. Kulikovsky. The Role of Polymorphism of Hereditary Thrombophilia Candidate Genes in the Development of Arterial Hypertension in Women with Preeclampsia.. http://www.sysrevpharm.org//?mno=111693 [Access: June 02, 2020]. doi:10.31838/srp.2020.6.03


AMA (American Medical Association) Style

Oleg V. Golovchenko, Maria Yu. Abramova, Oksana B. Altukhova, Irina N. Verzilina, Natalya A. Rudyh, Vladimir F. Kulikovsky. The Role of Polymorphism of Hereditary Thrombophilia Candidate Genes in the Development of Arterial Hypertension in Women with Preeclampsia.. SRP. 2020; 11(6): 11-15. doi:10.31838/srp.2020.6.03



Vancouver/ICMJE Style

Oleg V. Golovchenko, Maria Yu. Abramova, Oksana B. Altukhova, Irina N. Verzilina, Natalya A. Rudyh, Vladimir F. Kulikovsky. The Role of Polymorphism of Hereditary Thrombophilia Candidate Genes in the Development of Arterial Hypertension in Women with Preeclampsia.. SRP. (2020), [cited June 02, 2020]; 11(6): 11-15. doi:10.31838/srp.2020.6.03



Harvard Style

Oleg V. Golovchenko, Maria Yu. Abramova, Oksana B. Altukhova, Irina N. Verzilina, Natalya A. Rudyh, Vladimir F. Kulikovsky (2020) The Role of Polymorphism of Hereditary Thrombophilia Candidate Genes in the Development of Arterial Hypertension in Women with Preeclampsia.. SRP, 11 (6), 11-15. doi:10.31838/srp.2020.6.03



Turabian Style

Oleg V. Golovchenko, Maria Yu. Abramova, Oksana B. Altukhova, Irina N. Verzilina, Natalya A. Rudyh, Vladimir F. Kulikovsky. 2020. The Role of Polymorphism of Hereditary Thrombophilia Candidate Genes in the Development of Arterial Hypertension in Women with Preeclampsia.. Systematic Reviews in Pharmacy, 11 (6), 11-15. doi:10.31838/srp.2020.6.03



Chicago Style

Oleg V. Golovchenko, Maria Yu. Abramova, Oksana B. Altukhova, Irina N. Verzilina, Natalya A. Rudyh, Vladimir F. Kulikovsky. "The Role of Polymorphism of Hereditary Thrombophilia Candidate Genes in the Development of Arterial Hypertension in Women with Preeclampsia.." Systematic Reviews in Pharmacy 11 (2020), 11-15. doi:10.31838/srp.2020.6.03



MLA (The Modern Language Association) Style

Oleg V. Golovchenko, Maria Yu. Abramova, Oksana B. Altukhova, Irina N. Verzilina, Natalya A. Rudyh, Vladimir F. Kulikovsky. "The Role of Polymorphism of Hereditary Thrombophilia Candidate Genes in the Development of Arterial Hypertension in Women with Preeclampsia.." Systematic Reviews in Pharmacy 11.6 (2020), 11-15. Print. doi:10.31838/srp.2020.6.03



APA (American Psychological Association) Style

Oleg V. Golovchenko, Maria Yu. Abramova, Oksana B. Altukhova, Irina N. Verzilina, Natalya A. Rudyh, Vladimir F. Kulikovsky (2020) The Role of Polymorphism of Hereditary Thrombophilia Candidate Genes in the Development of Arterial Hypertension in Women with Preeclampsia.. Systematic Reviews in Pharmacy, 11 (6), 11-15. doi:10.31838/srp.2020.6.03





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