E-ISSN 0976-2779 | ISSN 0975-8453
 

Review Article 


The Pathological Features of Cyclophosphamide Induced Multi-Organs Toxicity in Male Wister Rats

Hutheyfa Abdulhussein Al-Salih, Nabeel Mohammed Al-Sharafi, Saif Sattar Al-Qabi, Ali Adnan Al-Darwesh.

Abstract
Cyclophosphamide has the ability to induce multi-organ toxicity. The current study was conducted to investigate the toxicity effects of one dose and two doses of intraperitoneal administration of cyclophosphamide at dose of 50 mg/kg of body weight in male Wister rats. Fifteen male rats were assigned into three group five rats each group namely, control, 1-dose, and 2-doses. 1-dose group rats received one dose of cyclophosphamide at dose of 50 mg/kg of body weight, and 2-doses group rats received two doses of cyclophosphamide at dose of 50 mg/kg of body weight. Liver, lungs, kidneys, spleen and testes weight were recorded and collected for histopathological examination. The results showed a decrement in testes and spleen weight of 2-doses treated rats. The histopathology results showed pathological changes in all examined organs of cyclophosphamide treated rat. The fibrosis lesion was observed in 2-doses group’s affected organs. Testicular injury in the 2-doses group involved 10% of the affected testis. In conclusion, cyclophosphamide treatment at dose of 50 mg/kg of body weight to male Wister rats induced multi-organs toxicity. The rats that received two doses of cyclophosphamide as dose of 50 mg/kg of body weight induced fibrosis in affected organs and elevated the testicular injury.

Key words: Cyclophosphamide toxicity, liver toxicity, testes toxicity and kidneys toxicity


 
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How to Cite this Article
Pubmed Style

Hutheyfa Abdulhussein Al-Salih, Nabeel Mohammed Al-Sharafi, Saif Sattar Al-Qabi, Ali Adnan Al-Darwesh. The Pathological Features of Cyclophosphamide Induced Multi-Organs Toxicity in Male Wister Rats. SRP. 2020; 11(6): 45-49. doi:10.31838/srp.2020.6.10


Web Style

Hutheyfa Abdulhussein Al-Salih, Nabeel Mohammed Al-Sharafi, Saif Sattar Al-Qabi, Ali Adnan Al-Darwesh. The Pathological Features of Cyclophosphamide Induced Multi-Organs Toxicity in Male Wister Rats. http://www.sysrevpharm.org//?mno=112573 [Access: June 04, 2020]. doi:10.31838/srp.2020.6.10


AMA (American Medical Association) Style

Hutheyfa Abdulhussein Al-Salih, Nabeel Mohammed Al-Sharafi, Saif Sattar Al-Qabi, Ali Adnan Al-Darwesh. The Pathological Features of Cyclophosphamide Induced Multi-Organs Toxicity in Male Wister Rats. SRP. 2020; 11(6): 45-49. doi:10.31838/srp.2020.6.10



Vancouver/ICMJE Style

Hutheyfa Abdulhussein Al-Salih, Nabeel Mohammed Al-Sharafi, Saif Sattar Al-Qabi, Ali Adnan Al-Darwesh. The Pathological Features of Cyclophosphamide Induced Multi-Organs Toxicity in Male Wister Rats. SRP. (2020), [cited June 04, 2020]; 11(6): 45-49. doi:10.31838/srp.2020.6.10



Harvard Style

Hutheyfa Abdulhussein Al-Salih, Nabeel Mohammed Al-Sharafi, Saif Sattar Al-Qabi, Ali Adnan Al-Darwesh (2020) The Pathological Features of Cyclophosphamide Induced Multi-Organs Toxicity in Male Wister Rats. SRP, 11 (6), 45-49. doi:10.31838/srp.2020.6.10



Turabian Style

Hutheyfa Abdulhussein Al-Salih, Nabeel Mohammed Al-Sharafi, Saif Sattar Al-Qabi, Ali Adnan Al-Darwesh. 2020. The Pathological Features of Cyclophosphamide Induced Multi-Organs Toxicity in Male Wister Rats. Systematic Reviews in Pharmacy, 11 (6), 45-49. doi:10.31838/srp.2020.6.10



Chicago Style

Hutheyfa Abdulhussein Al-Salih, Nabeel Mohammed Al-Sharafi, Saif Sattar Al-Qabi, Ali Adnan Al-Darwesh. "The Pathological Features of Cyclophosphamide Induced Multi-Organs Toxicity in Male Wister Rats." Systematic Reviews in Pharmacy 11 (2020), 45-49. doi:10.31838/srp.2020.6.10



MLA (The Modern Language Association) Style

Hutheyfa Abdulhussein Al-Salih, Nabeel Mohammed Al-Sharafi, Saif Sattar Al-Qabi, Ali Adnan Al-Darwesh. "The Pathological Features of Cyclophosphamide Induced Multi-Organs Toxicity in Male Wister Rats." Systematic Reviews in Pharmacy 11.6 (2020), 45-49. Print. doi:10.31838/srp.2020.6.10



APA (American Psychological Association) Style

Hutheyfa Abdulhussein Al-Salih, Nabeel Mohammed Al-Sharafi, Saif Sattar Al-Qabi, Ali Adnan Al-Darwesh (2020) The Pathological Features of Cyclophosphamide Induced Multi-Organs Toxicity in Male Wister Rats. Systematic Reviews in Pharmacy, 11 (6), 45-49. doi:10.31838/srp.2020.6.10





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