E-ISSN 0976-2779 | ISSN 0975-8453
 

Review Article 


The Effect of Single Type Black Garlic (Allium Sativum L.) Extract on the Cell of Langerhans Islets and the Kidney Tubular Microscopy in Male Wistar Rats (Rattus Norvegicus) Models of Diabetes Mellitus

Gita Sekar Prihanti, Alifa Faradilla, Masita Rahman.

Abstract
Diabetes Mellitus cause oxidative stress. Oxidative stress is the main contributor of the pathogenesis of tubular damage. Black garlic (Allium sativum L) contain antioxidant such as polyphenol and flavonoid can regenerate the cell of Langerhans islets and the kidney tubular in rats with diabetes mellitus model. To indentify the effect of black garlic (Allium sativum L.) extract on the cell of Langerhans islets and the kidney tubular microscopy in rats models of diabetes mellitus. This research is True Experimental with post-test only control group design. The samples were divided into 4 groups. Control group was given alloxan 24 mg/0,3 ml, group 1, 2, and 3 were given 24 mg/0,3ml and black garlic (Allium sativum L.) extracts at dose 0,15, 0,3, and 0,6 (ml/200gBW/day). Treatment was given orally per day within 14 days. Statistical analysis used Post Hoc and t-test. Results was found significant of differences (p<0.05) in each group of treatment and control group. Pancreas histopathological description of rat showed that there was improvement as indicated by average total of cells endocrine in Langerhans islets and showed there is effect of black garlic extract on the decrease of hydropic degeneration in the kidney tubular cells. Black garlic (Allium sativum L.) extract given effect on the kidney tubular microscopy and Langerhans Islet in Male Wistar Rats (Rattus norvergicus) Models of Diabetes Mellitus

Key words: Extract, Allium sativum L., black garlic (Allium sativum L.), Langerhans Islet, Kidney tubular, diabetes mellitus.


 
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Pubmed Style

Gita Sekar Prihanti, Alifa Faradilla, Masita Rahman. The Effect of Single Type Black Garlic (Allium Sativum L.) Extract on the Cell of Langerhans Islets and the Kidney Tubular Microscopy in Male Wistar Rats (Rattus Norvegicus) Models of Diabetes Mellitus. SRP. 2020; 11(6): 290-296. doi:10.31838/srp.2020.6.46


Web Style

Gita Sekar Prihanti, Alifa Faradilla, Masita Rahman. The Effect of Single Type Black Garlic (Allium Sativum L.) Extract on the Cell of Langerhans Islets and the Kidney Tubular Microscopy in Male Wistar Rats (Rattus Norvegicus) Models of Diabetes Mellitus. http://www.sysrevpharm.org//?mno=113851 [Access: June 09, 2020]. doi:10.31838/srp.2020.6.46


AMA (American Medical Association) Style

Gita Sekar Prihanti, Alifa Faradilla, Masita Rahman. The Effect of Single Type Black Garlic (Allium Sativum L.) Extract on the Cell of Langerhans Islets and the Kidney Tubular Microscopy in Male Wistar Rats (Rattus Norvegicus) Models of Diabetes Mellitus. SRP. 2020; 11(6): 290-296. doi:10.31838/srp.2020.6.46



Vancouver/ICMJE Style

Gita Sekar Prihanti, Alifa Faradilla, Masita Rahman. The Effect of Single Type Black Garlic (Allium Sativum L.) Extract on the Cell of Langerhans Islets and the Kidney Tubular Microscopy in Male Wistar Rats (Rattus Norvegicus) Models of Diabetes Mellitus. SRP. (2020), [cited June 09, 2020]; 11(6): 290-296. doi:10.31838/srp.2020.6.46



Harvard Style

Gita Sekar Prihanti, Alifa Faradilla, Masita Rahman (2020) The Effect of Single Type Black Garlic (Allium Sativum L.) Extract on the Cell of Langerhans Islets and the Kidney Tubular Microscopy in Male Wistar Rats (Rattus Norvegicus) Models of Diabetes Mellitus. SRP, 11 (6), 290-296. doi:10.31838/srp.2020.6.46



Turabian Style

Gita Sekar Prihanti, Alifa Faradilla, Masita Rahman. 2020. The Effect of Single Type Black Garlic (Allium Sativum L.) Extract on the Cell of Langerhans Islets and the Kidney Tubular Microscopy in Male Wistar Rats (Rattus Norvegicus) Models of Diabetes Mellitus. Systematic Reviews in Pharmacy, 11 (6), 290-296. doi:10.31838/srp.2020.6.46



Chicago Style

Gita Sekar Prihanti, Alifa Faradilla, Masita Rahman. "The Effect of Single Type Black Garlic (Allium Sativum L.) Extract on the Cell of Langerhans Islets and the Kidney Tubular Microscopy in Male Wistar Rats (Rattus Norvegicus) Models of Diabetes Mellitus." Systematic Reviews in Pharmacy 11 (2020), 290-296. doi:10.31838/srp.2020.6.46



MLA (The Modern Language Association) Style

Gita Sekar Prihanti, Alifa Faradilla, Masita Rahman. "The Effect of Single Type Black Garlic (Allium Sativum L.) Extract on the Cell of Langerhans Islets and the Kidney Tubular Microscopy in Male Wistar Rats (Rattus Norvegicus) Models of Diabetes Mellitus." Systematic Reviews in Pharmacy 11.6 (2020), 290-296. Print. doi:10.31838/srp.2020.6.46



APA (American Psychological Association) Style

Gita Sekar Prihanti, Alifa Faradilla, Masita Rahman (2020) The Effect of Single Type Black Garlic (Allium Sativum L.) Extract on the Cell of Langerhans Islets and the Kidney Tubular Microscopy in Male Wistar Rats (Rattus Norvegicus) Models of Diabetes Mellitus. Systematic Reviews in Pharmacy, 11 (6), 290-296. doi:10.31838/srp.2020.6.46





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