E-ISSN 0976-2779 | ISSN 0975-8453
 

Review Article 


Sargassum duplicatum Extract Reduced Artritis Severity Score and Periarticular Tissue Matrix Metalloproteinase-1 (Mmp-1) Expression in Ajuvan Artritis Exposed to Cold Stressor

Fitri Handajani, Sulistiana Prabowo.

Abstract
In rheumatoid arthritis, significant increase of matrix metalloproteinase-1 (MMP-1) expression results in destruction of cartilage’s collagen, joint’s bone and tendon. Cold stressor increase reactive oxygen species (ROS) production caused by increased oxidative phosphorylation and oxidant compounds can increase MMP-1 production. Sargassum duplicatum contains antioxidant compounds, including polyphenols (flavonoids and phlorotannin) and fucoxanthin.
The purpose of this study was to show the effect of Sargassum duplicatum extract (ESD) in reducing arthritis severity score and inhibiting periarticular tissue MMP-1 expression in adjuvant arthritic rat exposed to cold stressor.
In this study 30 male adjuvant arthritis (AA) rats divided into three groups: 1) without treatment; 2) exposed to cold stressor of 5o C for 15 minutes on day 8 - 14; 3) exposed to cold stressor and given oral ESD extract 400 mg / kg BW / day on day 1 - 21. At the end of the study, subjective arthritis severity score were assessed and periarticular tissue MMP-1 expression were analysed using immunohistochistry methods.
Mann Whitney statistical analysis showed exposure to cold stressor increase arthritis severity score significantly (p=0.002). Treatment with ESD reduce arthritis severity score significantly in AA rats exposed to cold stressors (p=0.001). Anova test results showed that MMP-1 expression were significantly increase in AA rats exposed to cold stressors compared to the group unexposed to cold stressors (p=0.001). ESD treatment significantly reduce the MMP-1 expression in AA rats exposed to cold stressors (p=0.001).
In conclusion this study showed that cold stressor increased arthritis severity score and MMP-1 expression in AA, while antioxidant content of ESD decreased arthritis severity score and MMP-1 expression.

Key words: Sargassum duplicatum, arthritis severity score, MMP-1, cold stressor


 
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Pubmed Style

Fitri Handajani, Sulistiana Prabowo. Sargassum duplicatum Extract Reduced Artritis Severity Score and Periarticular Tissue Matrix Metalloproteinase-1 (Mmp-1) Expression in Ajuvan Artritis Exposed to Cold Stressor. SRP. 2020; 11(6): 302-307. doi:10.31838/srp.2020.6.48


Web Style

Fitri Handajani, Sulistiana Prabowo. Sargassum duplicatum Extract Reduced Artritis Severity Score and Periarticular Tissue Matrix Metalloproteinase-1 (Mmp-1) Expression in Ajuvan Artritis Exposed to Cold Stressor. http://www.sysrevpharm.org//?mno=113860 [Access: June 09, 2020]. doi:10.31838/srp.2020.6.48


AMA (American Medical Association) Style

Fitri Handajani, Sulistiana Prabowo. Sargassum duplicatum Extract Reduced Artritis Severity Score and Periarticular Tissue Matrix Metalloproteinase-1 (Mmp-1) Expression in Ajuvan Artritis Exposed to Cold Stressor. SRP. 2020; 11(6): 302-307. doi:10.31838/srp.2020.6.48



Vancouver/ICMJE Style

Fitri Handajani, Sulistiana Prabowo. Sargassum duplicatum Extract Reduced Artritis Severity Score and Periarticular Tissue Matrix Metalloproteinase-1 (Mmp-1) Expression in Ajuvan Artritis Exposed to Cold Stressor. SRP. (2020), [cited June 09, 2020]; 11(6): 302-307. doi:10.31838/srp.2020.6.48



Harvard Style

Fitri Handajani, Sulistiana Prabowo (2020) Sargassum duplicatum Extract Reduced Artritis Severity Score and Periarticular Tissue Matrix Metalloproteinase-1 (Mmp-1) Expression in Ajuvan Artritis Exposed to Cold Stressor. SRP, 11 (6), 302-307. doi:10.31838/srp.2020.6.48



Turabian Style

Fitri Handajani, Sulistiana Prabowo. 2020. Sargassum duplicatum Extract Reduced Artritis Severity Score and Periarticular Tissue Matrix Metalloproteinase-1 (Mmp-1) Expression in Ajuvan Artritis Exposed to Cold Stressor. Systematic Reviews in Pharmacy, 11 (6), 302-307. doi:10.31838/srp.2020.6.48



Chicago Style

Fitri Handajani, Sulistiana Prabowo. "Sargassum duplicatum Extract Reduced Artritis Severity Score and Periarticular Tissue Matrix Metalloproteinase-1 (Mmp-1) Expression in Ajuvan Artritis Exposed to Cold Stressor." Systematic Reviews in Pharmacy 11 (2020), 302-307. doi:10.31838/srp.2020.6.48



MLA (The Modern Language Association) Style

Fitri Handajani, Sulistiana Prabowo. "Sargassum duplicatum Extract Reduced Artritis Severity Score and Periarticular Tissue Matrix Metalloproteinase-1 (Mmp-1) Expression in Ajuvan Artritis Exposed to Cold Stressor." Systematic Reviews in Pharmacy 11.6 (2020), 302-307. Print. doi:10.31838/srp.2020.6.48



APA (American Psychological Association) Style

Fitri Handajani, Sulistiana Prabowo (2020) Sargassum duplicatum Extract Reduced Artritis Severity Score and Periarticular Tissue Matrix Metalloproteinase-1 (Mmp-1) Expression in Ajuvan Artritis Exposed to Cold Stressor. Systematic Reviews in Pharmacy, 11 (6), 302-307. doi:10.31838/srp.2020.6.48





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