E-ISSN 0976-2779 | ISSN 0975-8453
 

Review Article 


Low Level Laser (Biophotomodulation) Therapy for the Treatment of Diabetic Foot Ulcers with 532 nm KTP Laser Induces Wound Healing, Fibroblast Proliferation and Over-expression of TGF-β

Mazin J. Mousa, Hayder Sabeeh Al Saffar, Hayder Abdul-Amir Maki Al-Hindy.

Abstract
Development of diabetic foot ulcer can be considered as the most apprehensive complication, exhausting both patients and the health care system. Due to treatment high failure rate, different modalities of treatment have been developed. Recently, low-level-laser-therapy (LLLT) was investigated on cell culture and on few clinical trials, utilizing infrared/near-infrared machines. The clinical and histological benefit of KTP-532nm LLLT on ulcers and the tissue expression of TGF-β before/after LLLT investigated in this study including eleven patients with empirical LLLT. Tissue samples were submitted for histopathological assessment from four patients before and after LLLT. Immunohistochemical expression of TGF-β was evaluated, using Wilcoxon-Signed statistical test.
All patients responded dramatically, 3 (27.27%) completely healed, 7 (63.36%) were poorly compliant despite their obvious response. One-patient (9.09%) ended with toe amputation because of underlying osteomyelitis. All histological sections showed dramatic increase of fibroblast TGF-β after receiving LLLT.
KTP-53nm LLLT enhances ulcer healing and TGF-β expression.

Key words: Diabetic ulcer, foot ulcer, low-level biophotomodulation therapy, KTP 532 nm


 
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Pubmed Style

Mazin J. Mousa, Hayder Sabeeh Al Saffar, Hayder Abdul-Amir Maki Al-Hindy. Low Level Laser (Biophotomodulation) Therapy for the Treatment of Diabetic Foot Ulcers with 532 nm KTP Laser Induces Wound Healing, Fibroblast Proliferation and Over-expression of TGF-β. SRP. 2020; 11(6): 396-403. doi:10.31838/srp.2020.6.63


Web Style

Mazin J. Mousa, Hayder Sabeeh Al Saffar, Hayder Abdul-Amir Maki Al-Hindy. Low Level Laser (Biophotomodulation) Therapy for the Treatment of Diabetic Foot Ulcers with 532 nm KTP Laser Induces Wound Healing, Fibroblast Proliferation and Over-expression of TGF-β. http://www.sysrevpharm.org//?mno=116274 [Access: June 18, 2020]. doi:10.31838/srp.2020.6.63


AMA (American Medical Association) Style

Mazin J. Mousa, Hayder Sabeeh Al Saffar, Hayder Abdul-Amir Maki Al-Hindy. Low Level Laser (Biophotomodulation) Therapy for the Treatment of Diabetic Foot Ulcers with 532 nm KTP Laser Induces Wound Healing, Fibroblast Proliferation and Over-expression of TGF-β. SRP. 2020; 11(6): 396-403. doi:10.31838/srp.2020.6.63



Vancouver/ICMJE Style

Mazin J. Mousa, Hayder Sabeeh Al Saffar, Hayder Abdul-Amir Maki Al-Hindy. Low Level Laser (Biophotomodulation) Therapy for the Treatment of Diabetic Foot Ulcers with 532 nm KTP Laser Induces Wound Healing, Fibroblast Proliferation and Over-expression of TGF-β. SRP. (2020), [cited June 18, 2020]; 11(6): 396-403. doi:10.31838/srp.2020.6.63



Harvard Style

Mazin J. Mousa, Hayder Sabeeh Al Saffar, Hayder Abdul-Amir Maki Al-Hindy (2020) Low Level Laser (Biophotomodulation) Therapy for the Treatment of Diabetic Foot Ulcers with 532 nm KTP Laser Induces Wound Healing, Fibroblast Proliferation and Over-expression of TGF-β. SRP, 11 (6), 396-403. doi:10.31838/srp.2020.6.63



Turabian Style

Mazin J. Mousa, Hayder Sabeeh Al Saffar, Hayder Abdul-Amir Maki Al-Hindy. 2020. Low Level Laser (Biophotomodulation) Therapy for the Treatment of Diabetic Foot Ulcers with 532 nm KTP Laser Induces Wound Healing, Fibroblast Proliferation and Over-expression of TGF-β. Systematic Reviews in Pharmacy, 11 (6), 396-403. doi:10.31838/srp.2020.6.63



Chicago Style

Mazin J. Mousa, Hayder Sabeeh Al Saffar, Hayder Abdul-Amir Maki Al-Hindy. "Low Level Laser (Biophotomodulation) Therapy for the Treatment of Diabetic Foot Ulcers with 532 nm KTP Laser Induces Wound Healing, Fibroblast Proliferation and Over-expression of TGF-β." Systematic Reviews in Pharmacy 11 (2020), 396-403. doi:10.31838/srp.2020.6.63



MLA (The Modern Language Association) Style

Mazin J. Mousa, Hayder Sabeeh Al Saffar, Hayder Abdul-Amir Maki Al-Hindy. "Low Level Laser (Biophotomodulation) Therapy for the Treatment of Diabetic Foot Ulcers with 532 nm KTP Laser Induces Wound Healing, Fibroblast Proliferation and Over-expression of TGF-β." Systematic Reviews in Pharmacy 11.6 (2020), 396-403. Print. doi:10.31838/srp.2020.6.63



APA (American Psychological Association) Style

Mazin J. Mousa, Hayder Sabeeh Al Saffar, Hayder Abdul-Amir Maki Al-Hindy (2020) Low Level Laser (Biophotomodulation) Therapy for the Treatment of Diabetic Foot Ulcers with 532 nm KTP Laser Induces Wound Healing, Fibroblast Proliferation and Over-expression of TGF-β. Systematic Reviews in Pharmacy, 11 (6), 396-403. doi:10.31838/srp.2020.6.63





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