E-ISSN 0976-2779 | ISSN 0975-8453
 

Review Article 


Association of Th-Tc protein CD28+ and Periodontal Inflammation among Indonesian Women with SLE Disease

Nanda Rachmad Putra Gofur, Kusworini Handono, Nurdiana, Handono Kalim, Cesarius Singgih Wahono, Sri Poeranto, Wisnu Barlianto.

Abstract
Introduction: Systemic Lupus Erythematosus (SLE) is a chronic autoimmune disorder characterized by secretion of autoantibodies and deposition of immune complexes associated with various clinical manifestations and tissue damage. activates T cell differentiation. T cells experience hyperactivity could produce defects in Th (T helper cell) and Tc (T cytotoxic), also loose CD28+ protein in surface marker. This study aims to associate Th and Tc protein CD28+ and Periodontal Inflammation in SLE disease.
Materials and Methods: Cross-sectional observational analytic study was conducted in 153 SLE patients where clinical examination and laboratory tests were done to assess the activity of the disease, periodontitis and evaluate lymphocytes T CD28 using flow cytometry. Clinical examination of periodontitis was using periodontal index (PI) and gingivitis was using gingival index (GI). PI assessment was done by a WHO Periodontal Examining Probe using Periodontal Index by Russel.
Results: Ratio Th/Tc in the SLE group was lower 0,7% than the control group. The percentage of Th CD28+ was lower 12,65% in SLE than the control group. Also, the percentage of Tc CD28+ was lower 5,28% in SLE than the control group. Then the total percentage CD28+ (both Th and Tc) was lower 23,5%. Confirming Th, Tc, and CD28+ protein between two groups were based on flow cytometry analysis. There was a significant strong association (p<0.01), Th CD28+ with periodontitis, and also Tc CD28with periodontitis in the SLE group (p<0.001). Both Th and Tc were loose CD28+ protein in the SLE group compared to control.
Conclusion: Both Th and Tc were loose CD28+ protein in the SLE group compared to control. There is association Th and Tc protein CD28+ and Periodontal Inflammation in SLE disease.

Key words: Periodontal Disease, Th, Tc, CD28+, SLE


 
ARTICLE TOOLS
Abstract
PDF Fulltext
How to cite this articleHow to cite this article
Citation Tools
Related Records
 Articles by Nanda Rachmad Putra Gofur
Articles by Kusworini Handono
Articles by Nurdiana
Articles by Handono Kalim
Articles by Cesarius Singgih Wahono
Articles by Sri Poeranto
Articles by Wisnu Barlianto
on Google
on Google Scholar


How to Cite this Article
Pubmed Style

Nanda Rachmad Putra Gofur, Kusworini Handono, Nurdiana, Handono Kalim, Cesarius Singgih Wahono, Sri Poeranto, Wisnu Barlianto. Association of Th-Tc protein CD28+ and Periodontal Inflammation among Indonesian Women with SLE Disease. SRP. 2020; 11(6): 580-586. doi:10.31838/srp.2020.6.88


Web Style

Nanda Rachmad Putra Gofur, Kusworini Handono, Nurdiana, Handono Kalim, Cesarius Singgih Wahono, Sri Poeranto, Wisnu Barlianto. Association of Th-Tc protein CD28+ and Periodontal Inflammation among Indonesian Women with SLE Disease. http://www.sysrevpharm.org//?mno=117013 [Access: June 20, 2020]. doi:10.31838/srp.2020.6.88


AMA (American Medical Association) Style

Nanda Rachmad Putra Gofur, Kusworini Handono, Nurdiana, Handono Kalim, Cesarius Singgih Wahono, Sri Poeranto, Wisnu Barlianto. Association of Th-Tc protein CD28+ and Periodontal Inflammation among Indonesian Women with SLE Disease. SRP. 2020; 11(6): 580-586. doi:10.31838/srp.2020.6.88



Vancouver/ICMJE Style

Nanda Rachmad Putra Gofur, Kusworini Handono, Nurdiana, Handono Kalim, Cesarius Singgih Wahono, Sri Poeranto, Wisnu Barlianto. Association of Th-Tc protein CD28+ and Periodontal Inflammation among Indonesian Women with SLE Disease. SRP. (2020), [cited June 20, 2020]; 11(6): 580-586. doi:10.31838/srp.2020.6.88



Harvard Style

Nanda Rachmad Putra Gofur, Kusworini Handono, Nurdiana, Handono Kalim, Cesarius Singgih Wahono, Sri Poeranto, Wisnu Barlianto (2020) Association of Th-Tc protein CD28+ and Periodontal Inflammation among Indonesian Women with SLE Disease. SRP, 11 (6), 580-586. doi:10.31838/srp.2020.6.88



Turabian Style

Nanda Rachmad Putra Gofur, Kusworini Handono, Nurdiana, Handono Kalim, Cesarius Singgih Wahono, Sri Poeranto, Wisnu Barlianto. 2020. Association of Th-Tc protein CD28+ and Periodontal Inflammation among Indonesian Women with SLE Disease. Systematic Reviews in Pharmacy, 11 (6), 580-586. doi:10.31838/srp.2020.6.88



Chicago Style

Nanda Rachmad Putra Gofur, Kusworini Handono, Nurdiana, Handono Kalim, Cesarius Singgih Wahono, Sri Poeranto, Wisnu Barlianto. "Association of Th-Tc protein CD28+ and Periodontal Inflammation among Indonesian Women with SLE Disease." Systematic Reviews in Pharmacy 11 (2020), 580-586. doi:10.31838/srp.2020.6.88



MLA (The Modern Language Association) Style

Nanda Rachmad Putra Gofur, Kusworini Handono, Nurdiana, Handono Kalim, Cesarius Singgih Wahono, Sri Poeranto, Wisnu Barlianto. "Association of Th-Tc protein CD28+ and Periodontal Inflammation among Indonesian Women with SLE Disease." Systematic Reviews in Pharmacy 11.6 (2020), 580-586. Print. doi:10.31838/srp.2020.6.88



APA (American Psychological Association) Style

Nanda Rachmad Putra Gofur, Kusworini Handono, Nurdiana, Handono Kalim, Cesarius Singgih Wahono, Sri Poeranto, Wisnu Barlianto (2020) Association of Th-Tc protein CD28+ and Periodontal Inflammation among Indonesian Women with SLE Disease. Systematic Reviews in Pharmacy, 11 (6), 580-586. doi:10.31838/srp.2020.6.88





Most Viewed Articles
  • Dental Development between Assisted Reproductive Therapy (Art) and Natural Conceived Children: A Comparative Pilot Study
    Norzaiti Mohd Kenali, Naimah Hasanah Mohd Fathil, Norbasyirah Bohari, Ahmad Faisal Ismail, Roszaman Ramli
    SRP. 2020; 11(1): 01-06
    » Abstract » doi: 10.5530/srp.2020.1.01

  • Psychometric properties of the World Health Organization Quality of life instrument, short form: Validity in the Vietnamese healthcare context
    Trung Quang Vo*, Bao Tran Thuy Tran, Ngan Thuy Nguyen, Tram ThiHuyen Nguyen, Thuy Phan Chung Tran
    SRP. 2020; 11(1): 14-22
    » Abstract » doi: 10.5530/srp.2020.1.03

  • A Prospective Review on Phyto-Pharmacological Aspects of Andrographis paniculata
    Govindraj Akilandeswari, Arumugam Vijaya Anand, Palanisamy Sampathkumar, Puthamohan Vinayaga Moorthi, Basavaraju Preethi
    SRP. 2019; 10(1): 15-19
    » Abstract » doi: 10.5530/srp.2019.1.3

  • A Review of Pharmacoeconomics: the key to “Healthcare for All”
    Hasamnis AA, Patil SS, Shaik Imam, Narendiran K
    SRP. 2019; 10(1): s40-s42
    » Abstract » doi: 10.5530/srp.2019.1s.21

  • Deuterium Depleted Water as an Adjuvant in Treatment of Cancer
    Anton Syroeshkin, Olga Levitskaya, Elena Uspenskaya, Tatiana Pleteneva, Daria Romaykina, Daria Ermakova
    SRP. 2019; 10(1): 112-117
    » Abstract » doi: 10.5530/srp.2019.1.19

  • Most Downloaded
  • Dental Development between Assisted Reproductive Therapy (Art) and Natural Conceived Children: A Comparative Pilot Study
    Norzaiti Mohd Kenali, Naimah Hasanah Mohd Fathil, Norbasyirah Bohari, Ahmad Faisal Ismail, Roszaman Ramli
    SRP. 2020; 11(1): 01-06
    » Abstract » doi: 10.5530/srp.2020.1.01

  • Manilkara zapota (L.) Royen Fruit Peel: A Phytochemical and Pharmacological Review
    Karle Pravin P, Dhawale Shashikant C
    SRP. 2019; 10(1): 11-14
    » Abstract » doi: 0.5530/srp.2019.1.2

  • Pharmacognostic and Phytopharmacological Overview on Bombax ceiba
    Pankaj Haribhau Chaudhary, Mukund Ganeshrao Tawar
    SRP. 2019; 10(1): 20-25
    » Abstract » doi: 10.5530/srp.2019.1.4

  • A Review of Pharmacoeconomics: the key to “Healthcare for All”
    Hasamnis AA, Patil SS, Shaik Imam, Narendiran K
    SRP. 2019; 10(1): s40-s42
    » Abstract » doi: 10.5530/srp.2019.1s.21

  • A Prospective Review on Phyto-Pharmacological Aspects of Andrographis paniculata
    Govindraj Akilandeswari, Arumugam Vijaya Anand, Palanisamy Sampathkumar, Puthamohan Vinayaga Moorthi, Basavaraju Preethi
    SRP. 2019; 10(1): 15-19
    » Abstract » doi: 10.5530/srp.2019.1.3

  • Most Cited Articles