E-ISSN 0976-2779 | ISSN 0975-8453
 

Review Article 


Effect of Oral Estradiol Valerate versus Vaginal Sildenafil on Endometrial Receptivity Evaluated by Ultrasound and Pregnancy Rate in Iraqi Infertile Females

Sundus Ali Dawood, Huda Ali Hussaini, Mufeda Ali.

Abstract
Female causes account for 30 percent of the overall infertility cases, five percent were attributed to uterine factors. Endometrial thickness (ET) is one of the best predictors of implantation rate and continued success rate for pregnancy. There were possible beneficial effects of sildenafil citrate or estradiol on endometrial receptivity so some reports discussed these potential effects
The aim: of this study is to compare the effect of estradiol valerate and vaginal sildenafil citrate on endometrial receptivity (endometrial thickness, serum Vascular Endothelial Growth Factor) and pregnancy rate in infertile Iraqi women
Subjects and Methods: Sixty infertile women were included in this comparative prospective study undergoing stimulated cycles and timed intercourse. Patients diagnosed previously to have thin endometrium were divided randomly into two groups. In group A, thirty patients were given estradiol valerate 2 mg tablet 12 hourly. In group B, 30 patients were given sildenafil citrate 25 mg vaginally every 6 hours. Patients were evaluated by using trans-vaginal sonography (TVS) to determine and compare the effects of estradiol valerate and vaginal sildenafil citrate on endometrial thickness, pattern, and serum assessment of Vascular Endothelial Growth Factor VEGF levels and pregnancy outcome in both groups.
Results: Mean endometrial thickness at HCG day was 9.19 mm in estradiol treated group and 8.86 mm in sildenafil treated group which was more in estradiol group but statistically insignificant (p>0.05). And endometrial triple line pattern in the Estradiol and sildenafil citrate groups was 96.6%, and 90% respectively. VEGF level in estradiol treated group was (220.5 ng/l) compared to sildenafil treated group (232.2), which is statistically significant difference (p <0.05). The pregnancy rates were 4 (16.7%) in group A and 11(73.3%) in group B which was statistically significant difference between the two groups (p<0.05)
Conclusions: Both Sildenafil citrate and estradiol valerate may be used to improve endometrial receptivity, but this study showed that the pregnancy rate with Sildenafil was significantly higher than with estradiol.

Key words: Infertility, Sildenafil, Estradiol valerate, Endometrial thickness endometrial receptivity


 
ARTICLE TOOLS
Abstract
PDF Fulltext
How to cite this articleHow to cite this article
Citation Tools
Related Records
 Articles by Sundus Ali Dawood
Articles by Huda Ali Hussaini
Articles by Mufeda Ali
on Google
on Google Scholar


How to Cite this Article
Pubmed Style

Sundus Ali Dawood, Huda Ali Hussaini, Mufeda Ali. Effect of Oral Estradiol Valerate versus Vaginal Sildenafil on Endometrial Receptivity Evaluated by Ultrasound and Pregnancy Rate in Iraqi Infertile Females. SRP. 2020; 11(6): 627-632. doi:10.31838/srp.2020.6.93


Web Style

Sundus Ali Dawood, Huda Ali Hussaini, Mufeda Ali. Effect of Oral Estradiol Valerate versus Vaginal Sildenafil on Endometrial Receptivity Evaluated by Ultrasound and Pregnancy Rate in Iraqi Infertile Females. http://www.sysrevpharm.org//?mno=117091 [Access: June 21, 2020]. doi:10.31838/srp.2020.6.93


AMA (American Medical Association) Style

Sundus Ali Dawood, Huda Ali Hussaini, Mufeda Ali. Effect of Oral Estradiol Valerate versus Vaginal Sildenafil on Endometrial Receptivity Evaluated by Ultrasound and Pregnancy Rate in Iraqi Infertile Females. SRP. 2020; 11(6): 627-632. doi:10.31838/srp.2020.6.93



Vancouver/ICMJE Style

Sundus Ali Dawood, Huda Ali Hussaini, Mufeda Ali. Effect of Oral Estradiol Valerate versus Vaginal Sildenafil on Endometrial Receptivity Evaluated by Ultrasound and Pregnancy Rate in Iraqi Infertile Females. SRP. (2020), [cited June 21, 2020]; 11(6): 627-632. doi:10.31838/srp.2020.6.93



Harvard Style

Sundus Ali Dawood, Huda Ali Hussaini, Mufeda Ali (2020) Effect of Oral Estradiol Valerate versus Vaginal Sildenafil on Endometrial Receptivity Evaluated by Ultrasound and Pregnancy Rate in Iraqi Infertile Females. SRP, 11 (6), 627-632. doi:10.31838/srp.2020.6.93



Turabian Style

Sundus Ali Dawood, Huda Ali Hussaini, Mufeda Ali. 2020. Effect of Oral Estradiol Valerate versus Vaginal Sildenafil on Endometrial Receptivity Evaluated by Ultrasound and Pregnancy Rate in Iraqi Infertile Females. Systematic Reviews in Pharmacy, 11 (6), 627-632. doi:10.31838/srp.2020.6.93



Chicago Style

Sundus Ali Dawood, Huda Ali Hussaini, Mufeda Ali. "Effect of Oral Estradiol Valerate versus Vaginal Sildenafil on Endometrial Receptivity Evaluated by Ultrasound and Pregnancy Rate in Iraqi Infertile Females." Systematic Reviews in Pharmacy 11 (2020), 627-632. doi:10.31838/srp.2020.6.93



MLA (The Modern Language Association) Style

Sundus Ali Dawood, Huda Ali Hussaini, Mufeda Ali. "Effect of Oral Estradiol Valerate versus Vaginal Sildenafil on Endometrial Receptivity Evaluated by Ultrasound and Pregnancy Rate in Iraqi Infertile Females." Systematic Reviews in Pharmacy 11.6 (2020), 627-632. Print. doi:10.31838/srp.2020.6.93



APA (American Psychological Association) Style

Sundus Ali Dawood, Huda Ali Hussaini, Mufeda Ali (2020) Effect of Oral Estradiol Valerate versus Vaginal Sildenafil on Endometrial Receptivity Evaluated by Ultrasound and Pregnancy Rate in Iraqi Infertile Females. Systematic Reviews in Pharmacy, 11 (6), 627-632. doi:10.31838/srp.2020.6.93





Most Viewed Articles
  • Dental Development between Assisted Reproductive Therapy (Art) and Natural Conceived Children: A Comparative Pilot Study
    Norzaiti Mohd Kenali, Naimah Hasanah Mohd Fathil, Norbasyirah Bohari, Ahmad Faisal Ismail, Roszaman Ramli
    SRP. 2020; 11(1): 01-06
    » Abstract » doi: 10.5530/srp.2020.1.01

  • Psychometric properties of the World Health Organization Quality of life instrument, short form: Validity in the Vietnamese healthcare context
    Trung Quang Vo*, Bao Tran Thuy Tran, Ngan Thuy Nguyen, Tram ThiHuyen Nguyen, Thuy Phan Chung Tran
    SRP. 2020; 11(1): 14-22
    » Abstract » doi: 10.5530/srp.2020.1.03

  • A Prospective Review on Phyto-Pharmacological Aspects of Andrographis paniculata
    Govindraj Akilandeswari, Arumugam Vijaya Anand, Palanisamy Sampathkumar, Puthamohan Vinayaga Moorthi, Basavaraju Preethi
    SRP. 2019; 10(1): 15-19
    » Abstract » doi: 10.5530/srp.2019.1.3

  • A Review of Pharmacoeconomics: the key to “Healthcare for All”
    Hasamnis AA, Patil SS, Shaik Imam, Narendiran K
    SRP. 2019; 10(1): s40-s42
    » Abstract » doi: 10.5530/srp.2019.1s.21

  • Deuterium Depleted Water as an Adjuvant in Treatment of Cancer
    Anton Syroeshkin, Olga Levitskaya, Elena Uspenskaya, Tatiana Pleteneva, Daria Romaykina, Daria Ermakova
    SRP. 2019; 10(1): 112-117
    » Abstract » doi: 10.5530/srp.2019.1.19

  • Most Downloaded
  • Dental Development between Assisted Reproductive Therapy (Art) and Natural Conceived Children: A Comparative Pilot Study
    Norzaiti Mohd Kenali, Naimah Hasanah Mohd Fathil, Norbasyirah Bohari, Ahmad Faisal Ismail, Roszaman Ramli
    SRP. 2020; 11(1): 01-06
    » Abstract » doi: 10.5530/srp.2020.1.01

  • Manilkara zapota (L.) Royen Fruit Peel: A Phytochemical and Pharmacological Review
    Karle Pravin P, Dhawale Shashikant C
    SRP. 2019; 10(1): 11-14
    » Abstract » doi: 0.5530/srp.2019.1.2

  • Pharmacognostic and Phytopharmacological Overview on Bombax ceiba
    Pankaj Haribhau Chaudhary, Mukund Ganeshrao Tawar
    SRP. 2019; 10(1): 20-25
    » Abstract » doi: 10.5530/srp.2019.1.4

  • A Review of Pharmacoeconomics: the key to “Healthcare for All”
    Hasamnis AA, Patil SS, Shaik Imam, Narendiran K
    SRP. 2019; 10(1): s40-s42
    » Abstract » doi: 10.5530/srp.2019.1s.21

  • A Prospective Review on Phyto-Pharmacological Aspects of Andrographis paniculata
    Govindraj Akilandeswari, Arumugam Vijaya Anand, Palanisamy Sampathkumar, Puthamohan Vinayaga Moorthi, Basavaraju Preethi
    SRP. 2019; 10(1): 15-19
    » Abstract » doi: 10.5530/srp.2019.1.3

  • Most Cited Articles