E-ISSN 0976-2779 | ISSN 0975-8453
 

Review Article 


Effect of the Combination of Demineralization Freeze Dried Dentin Matrix (DFDDM) and Moringa oleifera Lam on Osteoprotegerin (OPG) and Receptor Activator of Nuclear Factor Kapa B Ligand (RANKL) as a Marker of Bone Remodeling

Arni Irawaty Djais, Harun Achmad, Dewang Dewiayu, Austin Bertilova Carmelita, Iwan Aflanie, Bayu Indra Sukmana, Huldani.

Abstract
Background: The socket preservation has important role in alveolar bone resorption after tooth extraction. Various graft materials can be used in socket preservation must have osteoconductive, osteoinductive and osteoproliferation properties. Autogenous bone graft from dentin can be used because it has good osteoinductive and osteoconductive properties. One of the active substances of Moringa oleifera (MO) is flavonoids that have several beneficial characteristics as an anti‑inflammatory. The combination of anti-inflammatory with MO extract and Demineralization Freeze Dried Dentin Matrix (DFDDM) is expected to provide a good response to bone formation.
Aim: To determine the potential of combination Moringa oleifera and DFDDM in formation of OPG and RANKL expression post extraction cavia cobaya’s tooth.
Method: The mandibular incisors of 45 Cavia cobaya were extracted and divided into five groups subjected to different socket preservation treatments sequentially with MO, DFDDM, combination of MO and DFDDM, Gamacha® and polyethylene glycol (PEG). The cavia cobaya were examined on days 7, 14 and 21 after which the specimens were sacrificed and examined using an immunohistochemical technique. The resulting data were then analyzed using one‑way ANOVA and Tukey’s honestly significant difference tests.
Result: The One Way Anova test results showed a significant difference in OPG and RANKL between the groups (p<0.05) on day 7, 14 and 21 observation. The highest mean amount of OPG and lowest mean amount of RANKL were found in the third group.
Conclusion: Combination of MO and DFDDM can effectively generate OPG and RANKL expressions during the preservation of tooth extraction sockets.

Key words: Demineralization Freeze Dried Dentin Matrix (DFDDM), Moringa oleifera, Osteoprotegerin (OPG), Receptor Activator of Nuclear Factor Kapa B Ligand (RANKL)


 
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Pubmed Style

Arni Irawaty Djais, Harun Achmad, Dewang Dewiayu, Austin Bertilova Carmelita, Iwan Aflanie, Bayu Indra Sukmana, Huldani. Effect of the Combination of Demineralization Freeze Dried Dentin Matrix (DFDDM) and Moringa oleifera Lam on Osteoprotegerin (OPG) and Receptor Activator of Nuclear Factor Kapa B Ligand (RANKL) as a Marker of Bone Remodeling. SRP. 2020; 11(6): 771-779. doi:10.31838/srp.2020.6.113


Web Style

Arni Irawaty Djais, Harun Achmad, Dewang Dewiayu, Austin Bertilova Carmelita, Iwan Aflanie, Bayu Indra Sukmana, Huldani. Effect of the Combination of Demineralization Freeze Dried Dentin Matrix (DFDDM) and Moringa oleifera Lam on Osteoprotegerin (OPG) and Receptor Activator of Nuclear Factor Kapa B Ligand (RANKL) as a Marker of Bone Remodeling. http://www.sysrevpharm.org//?mno=119058 [Access: June 26, 2020]. doi:10.31838/srp.2020.6.113


AMA (American Medical Association) Style

Arni Irawaty Djais, Harun Achmad, Dewang Dewiayu, Austin Bertilova Carmelita, Iwan Aflanie, Bayu Indra Sukmana, Huldani. Effect of the Combination of Demineralization Freeze Dried Dentin Matrix (DFDDM) and Moringa oleifera Lam on Osteoprotegerin (OPG) and Receptor Activator of Nuclear Factor Kapa B Ligand (RANKL) as a Marker of Bone Remodeling. SRP. 2020; 11(6): 771-779. doi:10.31838/srp.2020.6.113



Vancouver/ICMJE Style

Arni Irawaty Djais, Harun Achmad, Dewang Dewiayu, Austin Bertilova Carmelita, Iwan Aflanie, Bayu Indra Sukmana, Huldani. Effect of the Combination of Demineralization Freeze Dried Dentin Matrix (DFDDM) and Moringa oleifera Lam on Osteoprotegerin (OPG) and Receptor Activator of Nuclear Factor Kapa B Ligand (RANKL) as a Marker of Bone Remodeling. SRP. (2020), [cited June 26, 2020]; 11(6): 771-779. doi:10.31838/srp.2020.6.113



Harvard Style

Arni Irawaty Djais, Harun Achmad, Dewang Dewiayu, Austin Bertilova Carmelita, Iwan Aflanie, Bayu Indra Sukmana, Huldani (2020) Effect of the Combination of Demineralization Freeze Dried Dentin Matrix (DFDDM) and Moringa oleifera Lam on Osteoprotegerin (OPG) and Receptor Activator of Nuclear Factor Kapa B Ligand (RANKL) as a Marker of Bone Remodeling. SRP, 11 (6), 771-779. doi:10.31838/srp.2020.6.113



Turabian Style

Arni Irawaty Djais, Harun Achmad, Dewang Dewiayu, Austin Bertilova Carmelita, Iwan Aflanie, Bayu Indra Sukmana, Huldani. 2020. Effect of the Combination of Demineralization Freeze Dried Dentin Matrix (DFDDM) and Moringa oleifera Lam on Osteoprotegerin (OPG) and Receptor Activator of Nuclear Factor Kapa B Ligand (RANKL) as a Marker of Bone Remodeling. Systematic Reviews in Pharmacy, 11 (6), 771-779. doi:10.31838/srp.2020.6.113



Chicago Style

Arni Irawaty Djais, Harun Achmad, Dewang Dewiayu, Austin Bertilova Carmelita, Iwan Aflanie, Bayu Indra Sukmana, Huldani. "Effect of the Combination of Demineralization Freeze Dried Dentin Matrix (DFDDM) and Moringa oleifera Lam on Osteoprotegerin (OPG) and Receptor Activator of Nuclear Factor Kapa B Ligand (RANKL) as a Marker of Bone Remodeling." Systematic Reviews in Pharmacy 11 (2020), 771-779. doi:10.31838/srp.2020.6.113



MLA (The Modern Language Association) Style

Arni Irawaty Djais, Harun Achmad, Dewang Dewiayu, Austin Bertilova Carmelita, Iwan Aflanie, Bayu Indra Sukmana, Huldani. "Effect of the Combination of Demineralization Freeze Dried Dentin Matrix (DFDDM) and Moringa oleifera Lam on Osteoprotegerin (OPG) and Receptor Activator of Nuclear Factor Kapa B Ligand (RANKL) as a Marker of Bone Remodeling." Systematic Reviews in Pharmacy 11.6 (2020), 771-779. Print. doi:10.31838/srp.2020.6.113



APA (American Psychological Association) Style

Arni Irawaty Djais, Harun Achmad, Dewang Dewiayu, Austin Bertilova Carmelita, Iwan Aflanie, Bayu Indra Sukmana, Huldani (2020) Effect of the Combination of Demineralization Freeze Dried Dentin Matrix (DFDDM) and Moringa oleifera Lam on Osteoprotegerin (OPG) and Receptor Activator of Nuclear Factor Kapa B Ligand (RANKL) as a Marker of Bone Remodeling. Systematic Reviews in Pharmacy, 11 (6), 771-779. doi:10.31838/srp.2020.6.113





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