E-ISSN 0976-2779 | ISSN 0975-8453
 

Review Article 


Human Leukocyte Antigen (HLA-G) Expression and Soluble HLA-G Levels in Women with Breast Cancer from Basrah Province in Iraq

Hadeel Saleem Touma, Wafaa Sadoon Shani, Talaat Sadoon Shani.

Abstract
HLA-G is one of the non-classical HLA class I molecules and it is known to be implicated in a tumor-driven immune escape mechanism in malignancy. The purpose of this study was to investigate soluble HLA-G (sHLA-G) and HLA-G expression in breast cancer. sHLA-G was determined by enzyme-linked Immunosorbent assay (ELISA) from plasma samples of 70 breast cancer patients and 35 healthy controls. HLA-G expression in breast cancer lesions was also analyzed by immunohistochemistry staining. The presence of HLA-G expression were analyzed and found to be involved in breast carcinogenesis. Levels of sHLA-G were higher in the breast cancer group compared to the control group and sHLA-G concentration could be used as a diagnostic marker for detecting breast cancer.

Key words: HLA-G, sHLA-G, cancer, breast cancer, expression


 
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How to Cite this Article
Pubmed Style

Hadeel Saleem Touma, Wafaa Sadoon Shani, Talaat Sadoon Shani. Human Leukocyte Antigen (HLA-G) Expression and Soluble HLA-G Levels in Women with Breast Cancer from Basrah Province in Iraq. SRP. 2020; 11(6): 871-877. doi:10.31838/srp.2020.6.125


Web Style

Hadeel Saleem Touma, Wafaa Sadoon Shani, Talaat Sadoon Shani. Human Leukocyte Antigen (HLA-G) Expression and Soluble HLA-G Levels in Women with Breast Cancer from Basrah Province in Iraq. http://www.sysrevpharm.org//?mno=120068 [Access: June 30, 2020]. doi:10.31838/srp.2020.6.125


AMA (American Medical Association) Style

Hadeel Saleem Touma, Wafaa Sadoon Shani, Talaat Sadoon Shani. Human Leukocyte Antigen (HLA-G) Expression and Soluble HLA-G Levels in Women with Breast Cancer from Basrah Province in Iraq. SRP. 2020; 11(6): 871-877. doi:10.31838/srp.2020.6.125



Vancouver/ICMJE Style

Hadeel Saleem Touma, Wafaa Sadoon Shani, Talaat Sadoon Shani. Human Leukocyte Antigen (HLA-G) Expression and Soluble HLA-G Levels in Women with Breast Cancer from Basrah Province in Iraq. SRP. (2020), [cited June 30, 2020]; 11(6): 871-877. doi:10.31838/srp.2020.6.125



Harvard Style

Hadeel Saleem Touma, Wafaa Sadoon Shani, Talaat Sadoon Shani (2020) Human Leukocyte Antigen (HLA-G) Expression and Soluble HLA-G Levels in Women with Breast Cancer from Basrah Province in Iraq. SRP, 11 (6), 871-877. doi:10.31838/srp.2020.6.125



Turabian Style

Hadeel Saleem Touma, Wafaa Sadoon Shani, Talaat Sadoon Shani. 2020. Human Leukocyte Antigen (HLA-G) Expression and Soluble HLA-G Levels in Women with Breast Cancer from Basrah Province in Iraq. Systematic Reviews in Pharmacy, 11 (6), 871-877. doi:10.31838/srp.2020.6.125



Chicago Style

Hadeel Saleem Touma, Wafaa Sadoon Shani, Talaat Sadoon Shani. "Human Leukocyte Antigen (HLA-G) Expression and Soluble HLA-G Levels in Women with Breast Cancer from Basrah Province in Iraq." Systematic Reviews in Pharmacy 11 (2020), 871-877. doi:10.31838/srp.2020.6.125



MLA (The Modern Language Association) Style

Hadeel Saleem Touma, Wafaa Sadoon Shani, Talaat Sadoon Shani. "Human Leukocyte Antigen (HLA-G) Expression and Soluble HLA-G Levels in Women with Breast Cancer from Basrah Province in Iraq." Systematic Reviews in Pharmacy 11.6 (2020), 871-877. Print. doi:10.31838/srp.2020.6.125



APA (American Psychological Association) Style

Hadeel Saleem Touma, Wafaa Sadoon Shani, Talaat Sadoon Shani (2020) Human Leukocyte Antigen (HLA-G) Expression and Soluble HLA-G Levels in Women with Breast Cancer from Basrah Province in Iraq. Systematic Reviews in Pharmacy, 11 (6), 871-877. doi:10.31838/srp.2020.6.125





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