E-ISSN 0976-2779 | ISSN 0975-8453
 

Review Article 


Freeze-Dried Liposome Formulation for Small Molecules, Nucleic Acid, and Protein Delivery

Raditya Weka Nugraheni, Nur Aini Mulyadi, Helmy Yusuf.

Abstract
Liposomes are one of the means in the drug delivery system that is quite promising because of its ability to carry active ingredients, both hydrophilic and lipophilic. In addition, the structure of lipid bilayers that resemble cell bilayer membranes is useful in optimizing liposomes' ability through increased internalization of active ingredients into cells. However, liposomes themselves are physically and chemically vulnerable systems, so increasing liposome stability is one of the primary considerations in liposome formulations. Lyophilization or freeze-drying can increase the shelf-life of liposomes, but the process itself is very extreme and prone to triggering damage to vesicle structures. Lyoprotectans from sugars and polyols are usually employed to improve the formulations' stability during the drying process. Physical characterization of the liposome end product is done by looking at the system's morphological appearance, crystallinity profile, thermal analysis, and functional group analysis.

Key words: Liposomes, stability, lyophilization, freeze-drying, lyoprotectants


 
ARTICLE TOOLS
Abstract
PDF Fulltext
How to cite this articleHow to cite this article
Citation Tools
Related Records
 Articles by Raditya Weka Nugraheni
Articles by Nur Aini Mulyadi
Articles by Helmy Yusuf
on Google
on Google Scholar


How to Cite this Article
Pubmed Style

Nugraheni RW, Mulyadi NA, Yusuf H. Freeze-Dried Liposome Formulation for Small Molecules, Nucleic Acid, and Protein Delivery. SRP. 2020; 11(7): 143-151. doi:10.31838/srp.2020.7.23


Web Style

Nugraheni RW, Mulyadi NA, Yusuf H. Freeze-Dried Liposome Formulation for Small Molecules, Nucleic Acid, and Protein Delivery. http://www.sysrevpharm.org//?mno=121936 [Access: August 06, 2020]. doi:10.31838/srp.2020.7.23


AMA (American Medical Association) Style

Nugraheni RW, Mulyadi NA, Yusuf H. Freeze-Dried Liposome Formulation for Small Molecules, Nucleic Acid, and Protein Delivery. SRP. 2020; 11(7): 143-151. doi:10.31838/srp.2020.7.23



Vancouver/ICMJE Style

Nugraheni RW, Mulyadi NA, Yusuf H. Freeze-Dried Liposome Formulation for Small Molecules, Nucleic Acid, and Protein Delivery. SRP. (2020), [cited August 06, 2020]; 11(7): 143-151. doi:10.31838/srp.2020.7.23



Harvard Style

Nugraheni, R. W., Mulyadi, . N. A. & Yusuf, . H. (2020) Freeze-Dried Liposome Formulation for Small Molecules, Nucleic Acid, and Protein Delivery. SRP, 11 (7), 143-151. doi:10.31838/srp.2020.7.23



Turabian Style

Nugraheni, Raditya Weka, Nur Aini Mulyadi, and Helmy Yusuf. 2020. Freeze-Dried Liposome Formulation for Small Molecules, Nucleic Acid, and Protein Delivery. Systematic Reviews in Pharmacy, 11 (7), 143-151. doi:10.31838/srp.2020.7.23



Chicago Style

Nugraheni, Raditya Weka, Nur Aini Mulyadi, and Helmy Yusuf. "Freeze-Dried Liposome Formulation for Small Molecules, Nucleic Acid, and Protein Delivery." Systematic Reviews in Pharmacy 11 (2020), 143-151. doi:10.31838/srp.2020.7.23



MLA (The Modern Language Association) Style

Nugraheni, Raditya Weka, Nur Aini Mulyadi, and Helmy Yusuf. "Freeze-Dried Liposome Formulation for Small Molecules, Nucleic Acid, and Protein Delivery." Systematic Reviews in Pharmacy 11.7 (2020), 143-151. Print. doi:10.31838/srp.2020.7.23



APA (American Psychological Association) Style

Nugraheni, R. W., Mulyadi, . N. A. & Yusuf, . H. (2020) Freeze-Dried Liposome Formulation for Small Molecules, Nucleic Acid, and Protein Delivery. Systematic Reviews in Pharmacy, 11 (7), 143-151. doi:10.31838/srp.2020.7.23





Most Viewed Articles
  • Dental Development between Assisted Reproductive Therapy (Art) and Natural Conceived Children: A Comparative Pilot Study
    Norzaiti Mohd Kenali, Naimah Hasanah Mohd Fathil, Norbasyirah Bohari, Ahmad Faisal Ismail, Roszaman Ramli
    SRP. 2020; 11(1): 01-06
    » Abstract » doi: 10.5530/srp.2020.1.01

  • Psychometric properties of the World Health Organization Quality of life instrument, short form: Validity in the Vietnamese healthcare context
    Trung Quang Vo*, Bao Tran Thuy Tran, Ngan Thuy Nguyen, Tram ThiHuyen Nguyen, Thuy Phan Chung Tran
    SRP. 2020; 11(1): 14-22
    » Abstract » doi: 10.5530/srp.2020.1.03

  • A Prospective Review on Phyto-Pharmacological Aspects of Andrographis paniculata
    Govindraj Akilandeswari, Arumugam Vijaya Anand, Palanisamy Sampathkumar, Puthamohan Vinayaga Moorthi, Basavaraju Preethi
    SRP. 2019; 10(1): 15-19
    » Abstract » doi: 10.5530/srp.2019.1.3

  • A Review of Pharmacoeconomics: the key to “Healthcare for All”
    Hasamnis AA, Patil SS, Shaik Imam, Narendiran K
    SRP. 2019; 10(1): s40-s42
    » Abstract » doi: 10.5530/srp.2019.1s.21

  • Deuterium Depleted Water as an Adjuvant in Treatment of Cancer
    Anton Syroeshkin, Olga Levitskaya, Elena Uspenskaya, Tatiana Pleteneva, Daria Romaykina, Daria Ermakova
    SRP. 2019; 10(1): 112-117
    » Abstract » doi: 10.5530/srp.2019.1.19

  • Most Downloaded
  • Dental Development between Assisted Reproductive Therapy (Art) and Natural Conceived Children: A Comparative Pilot Study
    Norzaiti Mohd Kenali, Naimah Hasanah Mohd Fathil, Norbasyirah Bohari, Ahmad Faisal Ismail, Roszaman Ramli
    SRP. 2020; 11(1): 01-06
    » Abstract » doi: 10.5530/srp.2020.1.01

  • Manilkara zapota (L.) Royen Fruit Peel: A Phytochemical and Pharmacological Review
    Karle Pravin P, Dhawale Shashikant C
    SRP. 2019; 10(1): 11-14
    » Abstract » doi: 0.5530/srp.2019.1.2

  • Pharmacognostic and Phytopharmacological Overview on Bombax ceiba
    Pankaj Haribhau Chaudhary, Mukund Ganeshrao Tawar
    SRP. 2019; 10(1): 20-25
    » Abstract » doi: 10.5530/srp.2019.1.4

  • A Review of Pharmacoeconomics: the key to “Healthcare for All”
    Hasamnis AA, Patil SS, Shaik Imam, Narendiran K
    SRP. 2019; 10(1): s40-s42
    » Abstract » doi: 10.5530/srp.2019.1s.21

  • A Prospective Review on Phyto-Pharmacological Aspects of Andrographis paniculata
    Govindraj Akilandeswari, Arumugam Vijaya Anand, Palanisamy Sampathkumar, Puthamohan Vinayaga Moorthi, Basavaraju Preethi
    SRP. 2019; 10(1): 15-19
    » Abstract » doi: 10.5530/srp.2019.1.3

  • Most Cited Articles