Abstract
The COVID-19 over-active other diseases within the human body especially respiratory system in which cytokine storm abnormally developed that results in the excessive killing of cells within the autoimmune system. To resolve this major issue, a systematic review paper is developed whose major aim is to propose such immunosuppression drugs that can easily seize the overacted immune system by blocking the cytokine storm action within human body, by systematically overview the previous scholars' articles, case reports and authentic websites based valid data. To justify this aim, different latest and authentic medicine's journals and papers are collected by posting four major keywords like "Cytokine Storm, Cytokine Storm in COVID-19 Symptoms, Immunosuppression Drugs and Immunosuppression Drugs to prevent the Cytokine storm.” The major databases of this review paper are Science Direct, Wiley Online Library, Elsevier, Springer, Google Scholar, and other related ones. After collecting the random data, the proper inclusion and exclusion criteria implemented to synchronize the data into an authentic format for content analysis. According to the previous scholars’ outcomes, Cyclosporine, Tocilizumab, Canakinumab, Corticosteroids are such immunosuppression drugs that play significant role in reducing the action of cytokine storm which becomes over-activated due to COVID-19 attack; also Remdesivir based immunopathology helps to reduce the auto-immune system of COVID-19 patient. But small dose of Tocilizumab and Hydroxychloroquine caused a major side effect on the COVID-19 patient. To further justify the hypothesis, rigorous studies are needed. Also, if the more searched papers considered for a review then more authentic outcomes will be generated

Key words: Cytokine Storm, COVID-19, Immunosuppression Drugs, autoimmune system