E-ISSN 0976-2779 | ISSN 0975-8453
 

Review Article 


Continuous Flow Injection Spectrophotometric Determination Of Mesalazine In Pharmaceutical Forms

Hind Hadi.

Abstract
Simple and sensitive continuous flow injection spectrophotometric method for the assay of mesalazine (MES) in commercial dosage forms was adopted. Using manifold with three channels, MES was determined by oxidative coupling reaction with o-coumaric acid after oxidation with sodium periodate in an alkaline medium. A blue color product was formed immediately at room temperature and measured maximally at λmax 659 nm. All the chemical and physical conditions of the flow system were studied and optimized to obtain high sensitivity and repeatability. Using optimum conditions, the Beer’s low obeyed over the range from 5-150 μg/mL MES with limits of detection and quantification of 1.48 and 4.94 μg/mL MES respectively. Minimum values of percentage error (-1.4%) and relative standard deviation (1.8%) indicated the accuracy and precision of the method. Also, good sampling frequency of 42 h-1 for the FI procedure was obtained. The developed method satisfactory used for rabid assay of MES in pharmaceutical forms.

Key words: Mesalazine, o-coumaric acid, oxidative coupling reaction, continuous flow injection.


 
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Pubmed Style

Hind Hadi. Continuous Flow Injection Spectrophotometric Determination Of Mesalazine In Pharmaceutical Forms . SRP. 2021; 12(2): 202-208. doi:10.31838/srp.2021.2.25


Web Style

Hind Hadi. Continuous Flow Injection Spectrophotometric Determination Of Mesalazine In Pharmaceutical Forms . http://www.sysrevpharm.org/?mno=13748 [Access: January 18, 2021]. doi:10.31838/srp.2021.2.25


AMA (American Medical Association) Style

Hind Hadi. Continuous Flow Injection Spectrophotometric Determination Of Mesalazine In Pharmaceutical Forms . SRP. 2021; 12(2): 202-208. doi:10.31838/srp.2021.2.25



Vancouver/ICMJE Style

Hind Hadi. Continuous Flow Injection Spectrophotometric Determination Of Mesalazine In Pharmaceutical Forms . SRP. (2021), [cited January 18, 2021]; 12(2): 202-208. doi:10.31838/srp.2021.2.25



Harvard Style

Hind Hadi (2021) Continuous Flow Injection Spectrophotometric Determination Of Mesalazine In Pharmaceutical Forms . SRP, 12 (2), 202-208. doi:10.31838/srp.2021.2.25



Turabian Style

Hind Hadi. 2021. Continuous Flow Injection Spectrophotometric Determination Of Mesalazine In Pharmaceutical Forms . Systematic Reviews in Pharmacy, 12 (2), 202-208. doi:10.31838/srp.2021.2.25



Chicago Style

Hind Hadi. "Continuous Flow Injection Spectrophotometric Determination Of Mesalazine In Pharmaceutical Forms ." Systematic Reviews in Pharmacy 12 (2021), 202-208. doi:10.31838/srp.2021.2.25



MLA (The Modern Language Association) Style

Hind Hadi. "Continuous Flow Injection Spectrophotometric Determination Of Mesalazine In Pharmaceutical Forms ." Systematic Reviews in Pharmacy 12.2 (2021), 202-208. Print. doi:10.31838/srp.2021.2.25



APA (American Psychological Association) Style

Hind Hadi (2021) Continuous Flow Injection Spectrophotometric Determination Of Mesalazine In Pharmaceutical Forms . Systematic Reviews in Pharmacy, 12 (2), 202-208. doi:10.31838/srp.2021.2.25





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