E-ISSN 0976-2779 | ISSN 0975-8453
 

Review Article 


The In Vitro Inhibitory Effects of Red Pomegranate (Punica granatum Linn) Extract on Fusobacterium Nucleatumís and Porphyromonas Gingivalisís Growth

Sri Hernawati, Pratiwi Soesilawati.

Abstract
Fusobacterium nucleatum is an anaerobic gram negative bacterium associated with halitosis since it can release sulphur. cysteine and methionine into a gas with the aroma of ammonia. hydrogen sulfide and methyl-mercaptan. Porphyromonas gingivalis is an anaerobic gram-negative bacterium causing periodontal disease and halitosis. Unfortunately, the antibacterial therapy used produces certain side-effects. On the other hand, previous research has posited that flavonoids can inhibit bacterial growth. Pomegranate fruit is known to contain very effective flavonoids. Red pomegranate fruit is even known to contain polyphenols (flavonoid and its derivatives. such as tannins and ellagitannin) as well as alkaloids. Therefore, red pomegranate fruit is expected to be used as an anti-bacterial. This research aimed to reveal the inhibitory activity of red pomegranate extract on the growth of Fusobacterium nucleatum and Porphyromonas gingivalis using a disc-diffusion method (Bauer-Kirby). The discs were soaked in red pomegranate extract at concentrations of 100%. 50%. 25%. 12.5% and 6.25%. 0.2% chlorhexidine (positive control) and sterile distilled water (negative control) were placed in petridishes that contained an agar medium and inoculated with F. Nucleatum bacteria. The petridishes were then placed in a dessicator and incubator at a temperature of 27o C for 24 hours. The zones of inhibition obtained were subsequently measured by three observers and their size recorded in millimeters (mm). There were zones of inhibition in all treatment groups. except the negative control group. Red pomegranate extract has inhibitory effects on the growth of Fusobacterium nucleatum and Porphyromonas gingivalis. The most pronounced inhibitory activity is found in red pomegranate extract at a concentration of 100%.

Key words: Inhibitory effects. Fusobacterium nucleatum. Porphyromonas gingivalis. Red pomegranate extract


 
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How to Cite this Article
Pubmed Style

Hernawati S, Soesilawati P. The In Vitro Inhibitory Effects of Red Pomegranate (Punica granatum Linn) Extract on Fusobacterium Nucleatumís and Porphyromonas Gingivalisís Growth. SRP. 2020; 11(6): 954-959. doi:10.31838srp.2020.6.134


Web Style

Hernawati S, Soesilawati P. The In Vitro Inhibitory Effects of Red Pomegranate (Punica granatum Linn) Extract on Fusobacterium Nucleatumís and Porphyromonas Gingivalisís Growth. http://www.sysrevpharm.org//?mno=21721 [Access: July 05, 2020]. doi:10.31838srp.2020.6.134


AMA (American Medical Association) Style

Hernawati S, Soesilawati P. The In Vitro Inhibitory Effects of Red Pomegranate (Punica granatum Linn) Extract on Fusobacterium Nucleatumís and Porphyromonas Gingivalisís Growth. SRP. 2020; 11(6): 954-959. doi:10.31838srp.2020.6.134



Vancouver/ICMJE Style

Hernawati S, Soesilawati P. The In Vitro Inhibitory Effects of Red Pomegranate (Punica granatum Linn) Extract on Fusobacterium Nucleatumís and Porphyromonas Gingivalisís Growth. SRP. (2020), [cited July 05, 2020]; 11(6): 954-959. doi:10.31838srp.2020.6.134



Harvard Style

Hernawati, S. & Soesilawati, . P. (2020) The In Vitro Inhibitory Effects of Red Pomegranate (Punica granatum Linn) Extract on Fusobacterium Nucleatumís and Porphyromonas Gingivalisís Growth. SRP, 11 (6), 954-959. doi:10.31838srp.2020.6.134



Turabian Style

Hernawati, Sri, and Pratiwi Soesilawati. 2020. The In Vitro Inhibitory Effects of Red Pomegranate (Punica granatum Linn) Extract on Fusobacterium Nucleatumís and Porphyromonas Gingivalisís Growth. Systematic Reviews in Pharmacy, 11 (6), 954-959. doi:10.31838srp.2020.6.134



Chicago Style

Hernawati, Sri, and Pratiwi Soesilawati. "The In Vitro Inhibitory Effects of Red Pomegranate (Punica granatum Linn) Extract on Fusobacterium Nucleatumís and Porphyromonas Gingivalisís Growth." Systematic Reviews in Pharmacy 11 (2020), 954-959. doi:10.31838srp.2020.6.134



MLA (The Modern Language Association) Style

Hernawati, Sri, and Pratiwi Soesilawati. "The In Vitro Inhibitory Effects of Red Pomegranate (Punica granatum Linn) Extract on Fusobacterium Nucleatumís and Porphyromonas Gingivalisís Growth." Systematic Reviews in Pharmacy 11.6 (2020), 954-959. Print. doi:10.31838srp.2020.6.134



APA (American Psychological Association) Style

Hernawati, S. & Soesilawati, . P. (2020) The In Vitro Inhibitory Effects of Red Pomegranate (Punica granatum Linn) Extract on Fusobacterium Nucleatumís and Porphyromonas Gingivalisís Growth. Systematic Reviews in Pharmacy, 11 (6), 954-959. doi:10.31838srp.2020.6.134





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