E-ISSN 0976-2779 | ISSN 0975-8453
 

Review Article 


The correlation between clinical manifestations and cytokine concentrations in Vietnamese children with dengue hemorrhagic fever

Tram Van Ta*, Hai Thanh Tran, Nam Thanh Nguyen, Quyen Nguyen Than Ha, Cameron Simmons.

Abstract
Background: All over the world, dengue hemorrhagic fever (DHF) causes mortality each year. To determine the development and severity of DHF, healthcare professionals usually record and monitor clinical manifestations and the functioning of the immune system. Nevertheless, many issues remain unclear as to the influence of cytokine concentrations on clinical symptoms.
Objective: This study was aimed at ascertaining the correlation between clinical manifestations and cytokine concentrations in children with DHF.
Materials and methods: A prospective cohort study was conducted involving 234 patients who were serologically diagnosed with dengue virus infection in Tien Giang Hospital. The patients’ clinical symptoms, such as fever duration on hospital admission, vomiting, abdominal pain, mucosal bleeding, bleeding under the skin, hepatomegaly, and high bodily temperature, were documented every day from admission to discharge. Cytokine concentrations were detected and measured via multiplex microbead immunoassay. The correlation between cytokine concentration and each clinical manifestation was then identified.
Results: Interleukin-6 (IL-6) concentration affected the manifestation of abdominal pain in the patients, and high concentrations of IL-2, IL-4, and IL-13 increased the occurrence of hepatomegaly. Temperature was influenced by IL-5, IL-10, and IL-12 concentrations.
Conclusion: The findings confirmed the correlation between cytokine concentrations and certain clinical manifestations.

Key words: Clinical manifestations, concentrations, concentrations, cytokine, dengue hemorrhagic fever, Vietnam.


 
ARTICLE TOOLS
Abstract
PDF Fulltext
How to cite this articleHow to cite this article
Citation Tools
Related Records
 Articles by Tram Van Ta*
Articles by Hai Thanh Tran
Articles by Nam Thanh Nguyen
Articles by Quyen Nguyen Than Ha
Articles by Cameron Simmons
on Google
on Google Scholar
Article Statistics
 Viewed: 507
Downloaded: 33


How to Cite this Article
Pubmed Style

Tram Van Ta, Hai Thanh Tran, Nam Thanh Nguyen, Quyen Nguyen Than Ha, Cameron Simmons. The correlation between clinical manifestations and cytokine concentrations in Vietnamese children with dengue hemorrhagic fever . SRP. 2019; 10(2): 15-21. doi:10.5530/srp.2019.2.03


Web Style

Tram Van Ta, Hai Thanh Tran, Nam Thanh Nguyen, Quyen Nguyen Than Ha, Cameron Simmons. The correlation between clinical manifestations and cytokine concentrations in Vietnamese children with dengue hemorrhagic fever . http://www.sysrevpharm.org//?mno=302644900 [Access: March 31, 2020]. doi:10.5530/srp.2019.2.03


AMA (American Medical Association) Style

Tram Van Ta, Hai Thanh Tran, Nam Thanh Nguyen, Quyen Nguyen Than Ha, Cameron Simmons. The correlation between clinical manifestations and cytokine concentrations in Vietnamese children with dengue hemorrhagic fever . SRP. 2019; 10(2): 15-21. doi:10.5530/srp.2019.2.03



Vancouver/ICMJE Style

Tram Van Ta, Hai Thanh Tran, Nam Thanh Nguyen, Quyen Nguyen Than Ha, Cameron Simmons. The correlation between clinical manifestations and cytokine concentrations in Vietnamese children with dengue hemorrhagic fever . SRP. (2019), [cited March 31, 2020]; 10(2): 15-21. doi:10.5530/srp.2019.2.03



Harvard Style

Tram Van Ta, Hai Thanh Tran, Nam Thanh Nguyen, Quyen Nguyen Than Ha, Cameron Simmons (2019) The correlation between clinical manifestations and cytokine concentrations in Vietnamese children with dengue hemorrhagic fever . SRP, 10 (2), 15-21. doi:10.5530/srp.2019.2.03



Turabian Style

Tram Van Ta, Hai Thanh Tran, Nam Thanh Nguyen, Quyen Nguyen Than Ha, Cameron Simmons. 2019. The correlation between clinical manifestations and cytokine concentrations in Vietnamese children with dengue hemorrhagic fever . Systematic Reviews in Pharmacy, 10 (2), 15-21. doi:10.5530/srp.2019.2.03



Chicago Style

Tram Van Ta, Hai Thanh Tran, Nam Thanh Nguyen, Quyen Nguyen Than Ha, Cameron Simmons. "The correlation between clinical manifestations and cytokine concentrations in Vietnamese children with dengue hemorrhagic fever ." Systematic Reviews in Pharmacy 10 (2019), 15-21. doi:10.5530/srp.2019.2.03



MLA (The Modern Language Association) Style

Tram Van Ta, Hai Thanh Tran, Nam Thanh Nguyen, Quyen Nguyen Than Ha, Cameron Simmons. "The correlation between clinical manifestations and cytokine concentrations in Vietnamese children with dengue hemorrhagic fever ." Systematic Reviews in Pharmacy 10.2 (2019), 15-21. Print. doi:10.5530/srp.2019.2.03



APA (American Psychological Association) Style

Tram Van Ta, Hai Thanh Tran, Nam Thanh Nguyen, Quyen Nguyen Than Ha, Cameron Simmons (2019) The correlation between clinical manifestations and cytokine concentrations in Vietnamese children with dengue hemorrhagic fever . Systematic Reviews in Pharmacy, 10 (2), 15-21. doi:10.5530/srp.2019.2.03





Most Viewed Articles
  • Dental Development between Assisted Reproductive Therapy (Art) and Natural Conceived Children: A Comparative Pilot Study
    Norzaiti Mohd Kenali, Naimah Hasanah Mohd Fathil, Norbasyirah Bohari, Ahmad Faisal Ismail, Roszaman Ramli
    SRP. 2020; 11(1): 01-06
    » Abstract » doi: 10.5530/srp.2020.1.01

  • Psychometric properties of the World Health Organization Quality of life instrument, short form: Validity in the Vietnamese healthcare context
    Trung Quang Vo*, Bao Tran Thuy Tran, Ngan Thuy Nguyen, Tram ThiHuyen Nguyen, Thuy Phan Chung Tran
    SRP. 2020; 11(1): 14-22
    » Abstract » doi: 10.5530/srp.2020.1.03

  • A Review of Pharmacoeconomics: the key to “Healthcare for All”
    Hasamnis AA, Patil SS, Shaik Imam, Narendiran K
    SRP. 2019; 10(1): s40-s42
    » Abstract » doi: 10.5530/srp.2019.1s.21

  • A Prospective Review on Phyto-Pharmacological Aspects of Andrographis paniculata
    Govindraj Akilandeswari, Arumugam Vijaya Anand, Palanisamy Sampathkumar, Puthamohan Vinayaga Moorthi, Basavaraju Preethi
    SRP. 2019; 10(1): 15-19
    » Abstract » doi: 10.5530/srp.2019.1.3

  • Deuterium Depleted Water as an Adjuvant in Treatment of Cancer
    Anton Syroeshkin, Olga Levitskaya, Elena Uspenskaya, Tatiana Pleteneva, Daria Romaykina, Daria Ermakova
    SRP. 2019; 10(1): 112-117
    » Abstract » doi: 10.5530/srp.2019.1.19

  • Most Downloaded
  • Dental Development between Assisted Reproductive Therapy (Art) and Natural Conceived Children: A Comparative Pilot Study
    Norzaiti Mohd Kenali, Naimah Hasanah Mohd Fathil, Norbasyirah Bohari, Ahmad Faisal Ismail, Roszaman Ramli
    SRP. 2020; 11(1): 01-06
    » Abstract » doi: 10.5530/srp.2020.1.01

  • Pharmacognostic and Phytopharmacological Overview on Bombax ceiba
    Pankaj Haribhau Chaudhary, Mukund Ganeshrao Tawar
    SRP. 2019; 10(1): 20-25
    » Abstract » doi: 10.5530/srp.2019.1.4

  • Manilkara zapota (L.) Royen Fruit Peel: A Phytochemical and Pharmacological Review
    Karle Pravin P, Dhawale Shashikant C
    SRP. 2019; 10(1): 11-14
    » Abstract » doi: 0.5530/srp.2019.1.2

  • A Review of Pharmacoeconomics: the key to “Healthcare for All”
    Hasamnis AA, Patil SS, Shaik Imam, Narendiran K
    SRP. 2019; 10(1): s40-s42
    » Abstract » doi: 10.5530/srp.2019.1s.21

  • A Prospective Review on Phyto-Pharmacological Aspects of Andrographis paniculata
    Govindraj Akilandeswari, Arumugam Vijaya Anand, Palanisamy Sampathkumar, Puthamohan Vinayaga Moorthi, Basavaraju Preethi
    SRP. 2019; 10(1): 15-19
    » Abstract » doi: 10.5530/srp.2019.1.3

  • Most Cited Articles