E-ISSN 0976-2779 | ISSN 0975-8453
 

Review Article 


Nephroprotective Potential Effect of Azilsartan in Renal Ischemia Reperfusion Injury /role VEGF Pathway

Aseel Noaman Ali, Murooj L. Altimimi, Haider Mahdi Al-Ardi,Najah R Hadi.

Abstract
The impairment of blood flow to the kidney causes renal injury occurs by ischemia/reperfusion in surgical procedures, in which the kidneys remain without blood supply for some time. This is observed during kidney transplantation, vascular surgery of aorta and renal arteries, and in partial nephrectomy. Inflammation is major contributor to the pathogenesis of renal ischemia/reperfusion in acute kidney injury with an endothelium loss, causing the vascular dysfunction and the angiogenesis deregulation. Azilsartan is an angiotensin II receptor antagonist used in the treatment of hypertension. It demonstrates organ protective effects in hypertension. In this study, we aim to assess the ability of azilsartanto exert potential protective effects on the kidney I/R and subsequent kidney dysfunctions in the rat through the modulation of pro‑inflammatory cytokinesand angiogenesis parameters (vascular endothelial growth factor receptor2 /vascular endothelial growth factor pathway). A total of 24 rats were randomly distributed into 4 groups (6 rats in each one) then they used in this experiment and the ischemia-reperfusion injury was induced in a rat model by bilateral renal artery clamping for 30 min and reperfusion for 2 h, and azilsartan (0.4 mg/kg) and vehicle was injected through intraperitoneally route before 30 min. prior of ischemia-reperfusion injury induction. Azilsartan administration could exert a protective role in the kidney against injury by significantly reducing the tissue levels of pro‑inflammatory cytokines (interleukin 1 beta, Monocyte chemoattractant protein-1and high mobility group box protein 1), lessen the serum levels of renal function parameters (blood urea nitrogen and serum creatinine), reduction of the histopathological severity score of renal damage and up regulation the angiogenesis markers (Vascular endothelial growth factor receptor 2, caveolin-1 and cluster of differentiation 34). All changes in the study parameters were significant (p value≤ 0.05).

Key words: nephron protection, histopathological effects, azilsartan


 
ARTICLE TOOLS
Abstract
PDF Fulltext
How to cite this articleHow to cite this article
Citation Tools
Related Records
 Articles by Aseel Noaman Ali
Articles by Murooj L. Altimimi
Articles by Haider Mahdi Al-Ardi
Articles by Najah R Hadi
on Google
on Google Scholar


How to Cite this Article
Pubmed Style

Aseel Noaman Ali, Murooj L. Altimimi, Haider Mahdi Al-Ardi,Najah R Hadi. Nephroprotective Potential Effect of Azilsartan in Renal Ischemia Reperfusion Injury /role VEGF Pathway. SRP. 2019; 10(2): 90-99. doi:10.5530/srp.2019.2.15


Web Style

Aseel Noaman Ali, Murooj L. Altimimi, Haider Mahdi Al-Ardi,Najah R Hadi. Nephroprotective Potential Effect of Azilsartan in Renal Ischemia Reperfusion Injury /role VEGF Pathway. http://www.sysrevpharm.org//?mno=302644928 [Access: June 02, 2020]. doi:10.5530/srp.2019.2.15


AMA (American Medical Association) Style

Aseel Noaman Ali, Murooj L. Altimimi, Haider Mahdi Al-Ardi,Najah R Hadi. Nephroprotective Potential Effect of Azilsartan in Renal Ischemia Reperfusion Injury /role VEGF Pathway. SRP. 2019; 10(2): 90-99. doi:10.5530/srp.2019.2.15



Vancouver/ICMJE Style

Aseel Noaman Ali, Murooj L. Altimimi, Haider Mahdi Al-Ardi,Najah R Hadi. Nephroprotective Potential Effect of Azilsartan in Renal Ischemia Reperfusion Injury /role VEGF Pathway. SRP. (2019), [cited June 02, 2020]; 10(2): 90-99. doi:10.5530/srp.2019.2.15



Harvard Style

Aseel Noaman Ali, Murooj L. Altimimi, Haider Mahdi Al-Ardi,Najah R Hadi (2019) Nephroprotective Potential Effect of Azilsartan in Renal Ischemia Reperfusion Injury /role VEGF Pathway. SRP, 10 (2), 90-99. doi:10.5530/srp.2019.2.15



Turabian Style

Aseel Noaman Ali, Murooj L. Altimimi, Haider Mahdi Al-Ardi,Najah R Hadi. 2019. Nephroprotective Potential Effect of Azilsartan in Renal Ischemia Reperfusion Injury /role VEGF Pathway. Systematic Reviews in Pharmacy, 10 (2), 90-99. doi:10.5530/srp.2019.2.15



Chicago Style

Aseel Noaman Ali, Murooj L. Altimimi, Haider Mahdi Al-Ardi,Najah R Hadi. "Nephroprotective Potential Effect of Azilsartan in Renal Ischemia Reperfusion Injury /role VEGF Pathway." Systematic Reviews in Pharmacy 10 (2019), 90-99. doi:10.5530/srp.2019.2.15



MLA (The Modern Language Association) Style

Aseel Noaman Ali, Murooj L. Altimimi, Haider Mahdi Al-Ardi,Najah R Hadi. "Nephroprotective Potential Effect of Azilsartan in Renal Ischemia Reperfusion Injury /role VEGF Pathway." Systematic Reviews in Pharmacy 10.2 (2019), 90-99. Print. doi:10.5530/srp.2019.2.15



APA (American Psychological Association) Style

Aseel Noaman Ali, Murooj L. Altimimi, Haider Mahdi Al-Ardi,Najah R Hadi (2019) Nephroprotective Potential Effect of Azilsartan in Renal Ischemia Reperfusion Injury /role VEGF Pathway. Systematic Reviews in Pharmacy, 10 (2), 90-99. doi:10.5530/srp.2019.2.15





Most Viewed Articles
  • Dental Development between Assisted Reproductive Therapy (Art) and Natural Conceived Children: A Comparative Pilot Study
    Norzaiti Mohd Kenali, Naimah Hasanah Mohd Fathil, Norbasyirah Bohari, Ahmad Faisal Ismail, Roszaman Ramli
    SRP. 2020; 11(1): 01-06
    » Abstract » doi: 10.5530/srp.2020.1.01

  • Psychometric properties of the World Health Organization Quality of life instrument, short form: Validity in the Vietnamese healthcare context
    Trung Quang Vo*, Bao Tran Thuy Tran, Ngan Thuy Nguyen, Tram ThiHuyen Nguyen, Thuy Phan Chung Tran
    SRP. 2020; 11(1): 14-22
    » Abstract » doi: 10.5530/srp.2020.1.03

  • A Prospective Review on Phyto-Pharmacological Aspects of Andrographis paniculata
    Govindraj Akilandeswari, Arumugam Vijaya Anand, Palanisamy Sampathkumar, Puthamohan Vinayaga Moorthi, Basavaraju Preethi
    SRP. 2019; 10(1): 15-19
    » Abstract » doi: 10.5530/srp.2019.1.3

  • A Review of Pharmacoeconomics: the key to Healthcare for All
    Hasamnis AA, Patil SS, Shaik Imam, Narendiran K
    SRP. 2019; 10(1): s40-s42
    » Abstract » doi: 10.5530/srp.2019.1s.21

  • Deuterium Depleted Water as an Adjuvant in Treatment of Cancer
    Anton Syroeshkin, Olga Levitskaya, Elena Uspenskaya, Tatiana Pleteneva, Daria Romaykina, Daria Ermakova
    SRP. 2019; 10(1): 112-117
    » Abstract » doi: 10.5530/srp.2019.1.19

  • Most Downloaded
  • Dental Development between Assisted Reproductive Therapy (Art) and Natural Conceived Children: A Comparative Pilot Study
    Norzaiti Mohd Kenali, Naimah Hasanah Mohd Fathil, Norbasyirah Bohari, Ahmad Faisal Ismail, Roszaman Ramli
    SRP. 2020; 11(1): 01-06
    » Abstract » doi: 10.5530/srp.2020.1.01

  • Manilkara zapota (L.) Royen Fruit Peel: A Phytochemical and Pharmacological Review
    Karle Pravin P, Dhawale Shashikant C
    SRP. 2019; 10(1): 11-14
    » Abstract » doi: 0.5530/srp.2019.1.2

  • Pharmacognostic and Phytopharmacological Overview on Bombax ceiba
    Pankaj Haribhau Chaudhary, Mukund Ganeshrao Tawar
    SRP. 2019; 10(1): 20-25
    » Abstract » doi: 10.5530/srp.2019.1.4

  • A Review of Pharmacoeconomics: the key to Healthcare for All
    Hasamnis AA, Patil SS, Shaik Imam, Narendiran K
    SRP. 2019; 10(1): s40-s42
    » Abstract » doi: 10.5530/srp.2019.1s.21

  • A Prospective Review on Phyto-Pharmacological Aspects of Andrographis paniculata
    Govindraj Akilandeswari, Arumugam Vijaya Anand, Palanisamy Sampathkumar, Puthamohan Vinayaga Moorthi, Basavaraju Preethi
    SRP. 2019; 10(1): 15-19
    » Abstract » doi: 10.5530/srp.2019.1.3

  • Most Cited Articles