E-ISSN 0976-2779 | ISSN 0975-8453
 

Review Article 


Oral Contraceptive Used More than 5 Years is associated with Increased Risk of Breast Cancer: A Meta-Analysis of 28,776 South East Asian Women

RICVAN DANA NINDREA, SUMADI LUKMAN ANWAR, WIRSMA ARIF HARAHAP, LUTFAN LAZUARDI, IWAN DWIPRAHASTO, TEGUH ARYANDONO.

Abstract
Breast cancer associated with variety of hormonal inter-ethnic and reproductive factors. Duration of oral contraceptives use with breast cancer risk is not well understood in Southeast Asian women. A comprehensive literature search of published articles from January 2001 to June 2019 (PubMed, ProQuest, and EBSCO online article databases) and meta-analysis were performed to link the duration of oral contraceptive application with risk of breast cancer among women in Southeast Asia. We identified the reference category, being ≤5 years' duration and >5 years' duration of oral contraceptive application. We use the Fixed and random-effect models to rely pooled odds ratios (OR). Egger's and Begg's test used for publication bias was presented with funnel plots. All analyzed data in Review Manager 5.3 (RevMan 5.3) and Stata version 14.2. A total of 385 studies were reviewed and 10 studies involving a total of 28,776 women were included in a meta-analysis.
This study found a slight increase in breast cancer risk in Southeast Asian women with oral contraceptives application ≤5 years with OR = 1.21 (95% CI 0.96-1.52, p>0.05). A higher risk of breast cancer was found in women with oral contraceptive application >5 years with OR = 2.66 (95% CI 1.79-3.94, p<0.00001).
Publication bias and heterogeneity were not found particularly in a group of Southeast Asian women with oral contraceptive application for more than 5 years. Oral contraceptives use more than 5 years are at a higher risk in breast cancer among women in Southeast Asia. Although other reproductive factors including age at first childbirth, menarche, menopause, and lactation might influence the risk of breast cancer.

Key words: Breast cancer, Five years, Oral contraceptive, Southeast Asia


 
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How to Cite this Article
Pubmed Style

RICVAN DANA NINDREA, SUMADI LUKMAN ANWAR, WIRSMA ARIF HARAHAP, LUTFAN LAZUARDI, IWAN DWIPRAHASTO, TEGUH ARYANDONO. Oral Contraceptive Used More than 5 Years is associated with Increased Risk of Breast Cancer: A Meta-Analysis of 28,776 South East Asian Women. SRP. 2019; 10(2): 137-148. doi:10.5530/srp.2019.2.22


Web Style

RICVAN DANA NINDREA, SUMADI LUKMAN ANWAR, WIRSMA ARIF HARAHAP, LUTFAN LAZUARDI, IWAN DWIPRAHASTO, TEGUH ARYANDONO. Oral Contraceptive Used More than 5 Years is associated with Increased Risk of Breast Cancer: A Meta-Analysis of 28,776 South East Asian Women. http://www.sysrevpharm.org//?mno=302644943 [Access: June 01, 2020]. doi:10.5530/srp.2019.2.22


AMA (American Medical Association) Style

RICVAN DANA NINDREA, SUMADI LUKMAN ANWAR, WIRSMA ARIF HARAHAP, LUTFAN LAZUARDI, IWAN DWIPRAHASTO, TEGUH ARYANDONO. Oral Contraceptive Used More than 5 Years is associated with Increased Risk of Breast Cancer: A Meta-Analysis of 28,776 South East Asian Women. SRP. 2019; 10(2): 137-148. doi:10.5530/srp.2019.2.22



Vancouver/ICMJE Style

RICVAN DANA NINDREA, SUMADI LUKMAN ANWAR, WIRSMA ARIF HARAHAP, LUTFAN LAZUARDI, IWAN DWIPRAHASTO, TEGUH ARYANDONO. Oral Contraceptive Used More than 5 Years is associated with Increased Risk of Breast Cancer: A Meta-Analysis of 28,776 South East Asian Women. SRP. (2019), [cited June 01, 2020]; 10(2): 137-148. doi:10.5530/srp.2019.2.22



Harvard Style

RICVAN DANA NINDREA, SUMADI LUKMAN ANWAR, WIRSMA ARIF HARAHAP, LUTFAN LAZUARDI, IWAN DWIPRAHASTO, TEGUH ARYANDONO (2019) Oral Contraceptive Used More than 5 Years is associated with Increased Risk of Breast Cancer: A Meta-Analysis of 28,776 South East Asian Women. SRP, 10 (2), 137-148. doi:10.5530/srp.2019.2.22



Turabian Style

RICVAN DANA NINDREA, SUMADI LUKMAN ANWAR, WIRSMA ARIF HARAHAP, LUTFAN LAZUARDI, IWAN DWIPRAHASTO, TEGUH ARYANDONO. 2019. Oral Contraceptive Used More than 5 Years is associated with Increased Risk of Breast Cancer: A Meta-Analysis of 28,776 South East Asian Women. Systematic Reviews in Pharmacy, 10 (2), 137-148. doi:10.5530/srp.2019.2.22



Chicago Style

RICVAN DANA NINDREA, SUMADI LUKMAN ANWAR, WIRSMA ARIF HARAHAP, LUTFAN LAZUARDI, IWAN DWIPRAHASTO, TEGUH ARYANDONO. "Oral Contraceptive Used More than 5 Years is associated with Increased Risk of Breast Cancer: A Meta-Analysis of 28,776 South East Asian Women." Systematic Reviews in Pharmacy 10 (2019), 137-148. doi:10.5530/srp.2019.2.22



MLA (The Modern Language Association) Style

RICVAN DANA NINDREA, SUMADI LUKMAN ANWAR, WIRSMA ARIF HARAHAP, LUTFAN LAZUARDI, IWAN DWIPRAHASTO, TEGUH ARYANDONO. "Oral Contraceptive Used More than 5 Years is associated with Increased Risk of Breast Cancer: A Meta-Analysis of 28,776 South East Asian Women." Systematic Reviews in Pharmacy 10.2 (2019), 137-148. Print. doi:10.5530/srp.2019.2.22



APA (American Psychological Association) Style

RICVAN DANA NINDREA, SUMADI LUKMAN ANWAR, WIRSMA ARIF HARAHAP, LUTFAN LAZUARDI, IWAN DWIPRAHASTO, TEGUH ARYANDONO (2019) Oral Contraceptive Used More than 5 Years is associated with Increased Risk of Breast Cancer: A Meta-Analysis of 28,776 South East Asian Women. Systematic Reviews in Pharmacy, 10 (2), 137-148. doi:10.5530/srp.2019.2.22





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