E-ISSN 0976-2779 | ISSN 0975-8453
 

Review Article 


Nephroprotective Potential Effect of Sacubitrilate in Renal Ischemia Reperfusion Injury Role of NF-Kbpathway in Rat

Alaa Kadhum Mosa, Basem I. Mohammad Al-Shibani, Mohammed A. Abdulhussein, Najah R. Hadi, Hyder Qassam, Yasmeen Ali Hussin.

Abstract
Acute kidney injury (AKI) with all advances in nursing measures and therapeutic strategies, such as kidney transplantation and dialysis, mortality rate of patients with AKI is very high in past 30 years. Despite the path physiology of IRI is not totally understood, several critical mechanisms leading in kidney failure have been demonstrated. In ischemic kidney and successive of generation of reactive oxygen species (ROS), re-oxygenation at reperfusion phase activate a cascade of destroying cellular responses causing to cell death, inflammation, and acute kidney failure. Sacubitrilate is neprilysininhibitor attenuated renal injury possibly through its anti-inflammatory and antioxidant effects. The main objective of the present paper is to study the Nephroprotective potential effect of Sacubitrilate in RIRI. Renal IRI causes significant (p<0.05) increase in tissue level of IL-1β, NGAL, f2- isoprostane, TLR-4 and NF-KB p65 and serum urea, creatinine. Pretreatment with, Sacubitrilate cause significant (p<0.05) decrease in tissue level of IL-1β, NF-KB p65, TLR-4, NGAL, f2- isoprostane, and serum urea, creatinine. Also cause significant reversal of tissue damage when compared with IRI group. Pretreatment with Sacubitrilate significantly decreases renal ischemia reperfusion injury in the rat via their pleiotropic effects as anti-oxidant, anti-inflammatory and anti- apoptotic activity.

Key words: Renal Ischemia/Reperfusion Injury (RIRI), Sacubitrilate.


 
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How to Cite this Article
Pubmed Style

Alaa Kadhum Mosa , Basem I. Mohammad Al-Shibani , Mohammed A. Abdulhussein , Najah R. Hadi , Hyder Qassam , Yasmeen Ali Hussin. Nephroprotective Potential Effect of Sacubitrilate in Renal Ischemia Reperfusion Injury Role of NF-Kbpathway in Rat. SRP. 2019; 10(1): 194-205. doi:10.5530/srp.2019.1.35


Web Style

Alaa Kadhum Mosa , Basem I. Mohammad Al-Shibani , Mohammed A. Abdulhussein , Najah R. Hadi , Hyder Qassam , Yasmeen Ali Hussin. Nephroprotective Potential Effect of Sacubitrilate in Renal Ischemia Reperfusion Injury Role of NF-Kbpathway in Rat. http://www.sysrevpharm.org//?mno=302644973 [Access: May 31, 2020]. doi:10.5530/srp.2019.1.35


AMA (American Medical Association) Style

Alaa Kadhum Mosa , Basem I. Mohammad Al-Shibani , Mohammed A. Abdulhussein , Najah R. Hadi , Hyder Qassam , Yasmeen Ali Hussin. Nephroprotective Potential Effect of Sacubitrilate in Renal Ischemia Reperfusion Injury Role of NF-Kbpathway in Rat. SRP. 2019; 10(1): 194-205. doi:10.5530/srp.2019.1.35



Vancouver/ICMJE Style

Alaa Kadhum Mosa , Basem I. Mohammad Al-Shibani , Mohammed A. Abdulhussein , Najah R. Hadi , Hyder Qassam , Yasmeen Ali Hussin. Nephroprotective Potential Effect of Sacubitrilate in Renal Ischemia Reperfusion Injury Role of NF-Kbpathway in Rat. SRP. (2019), [cited May 31, 2020]; 10(1): 194-205. doi:10.5530/srp.2019.1.35



Harvard Style

Alaa Kadhum Mosa , Basem I. Mohammad Al-Shibani , Mohammed A. Abdulhussein , Najah R. Hadi , Hyder Qassam , Yasmeen Ali Hussin (2019) Nephroprotective Potential Effect of Sacubitrilate in Renal Ischemia Reperfusion Injury Role of NF-Kbpathway in Rat. SRP, 10 (1), 194-205. doi:10.5530/srp.2019.1.35



Turabian Style

Alaa Kadhum Mosa , Basem I. Mohammad Al-Shibani , Mohammed A. Abdulhussein , Najah R. Hadi , Hyder Qassam , Yasmeen Ali Hussin. 2019. Nephroprotective Potential Effect of Sacubitrilate in Renal Ischemia Reperfusion Injury Role of NF-Kbpathway in Rat. Systematic Reviews in Pharmacy, 10 (1), 194-205. doi:10.5530/srp.2019.1.35



Chicago Style

Alaa Kadhum Mosa , Basem I. Mohammad Al-Shibani , Mohammed A. Abdulhussein , Najah R. Hadi , Hyder Qassam , Yasmeen Ali Hussin. "Nephroprotective Potential Effect of Sacubitrilate in Renal Ischemia Reperfusion Injury Role of NF-Kbpathway in Rat." Systematic Reviews in Pharmacy 10 (2019), 194-205. doi:10.5530/srp.2019.1.35



MLA (The Modern Language Association) Style

Alaa Kadhum Mosa , Basem I. Mohammad Al-Shibani , Mohammed A. Abdulhussein , Najah R. Hadi , Hyder Qassam , Yasmeen Ali Hussin. "Nephroprotective Potential Effect of Sacubitrilate in Renal Ischemia Reperfusion Injury Role of NF-Kbpathway in Rat." Systematic Reviews in Pharmacy 10.1 (2019), 194-205. Print. doi:10.5530/srp.2019.1.35



APA (American Psychological Association) Style

Alaa Kadhum Mosa , Basem I. Mohammad Al-Shibani , Mohammed A. Abdulhussein , Najah R. Hadi , Hyder Qassam , Yasmeen Ali Hussin (2019) Nephroprotective Potential Effect of Sacubitrilate in Renal Ischemia Reperfusion Injury Role of NF-Kbpathway in Rat. Systematic Reviews in Pharmacy, 10 (1), 194-205. doi:10.5530/srp.2019.1.35





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