E-ISSN 0976-2779 | ISSN 0975-8453
 

Review Article 


DMF Ameliorating Cerebral Ischemia/ Reperfusion Injury in Male Rats

Laith M Abbas Al-Huseini, Rihab H Al-Mudhaffer, Saif M Hassan, Najah R Hadi.

Abstract
Cerebral I/R causes oxygen deprivation to the brain tissue and generation of reactive oxygen species (ROS) which can stimulate immune responses, leading to inflammatory cells activation and infiltration. Methods: Rats were subjected to general anesthesia during which an occlusion of bilateral common carotid arteries for half hour then reperfusion for one hour with and without pretreatment with Dimethyl fumarate (DMF) at 50 mg/kg intraperitoneal (i.p) 24 hr. before ischemia.HO-1, TLR2, and TLR4 antibodies were assessment by IHC technique while ELISA type used to measure Nrf2, NF-κB and MDA in brain tissue levels. Levels of nuclear Nrf2 were increased significantly (P<0.05) in the DMF group. The levels of NF-κB and MDA were decreased significantly (P<0.05). Histological findings including: hemorrhage, dark neurons, and necrosis were reduced in DMF groups in addition to the reduction in the infarction area. Neuroprotective effect of DMF against cerebral I/R injury probably occurred via up-regulation of nuclear Nrf2 and down-regulation of inflammatory and oxidative stress.

Key words: Cerebral I/R, DMF, Nrf2, MDA, NF-κB, oxidative stress


 
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How to Cite this Article
Pubmed Style

LMAA, RHA, SMH, Hadi NR. DMF Ameliorating Cerebral Ischemia/ Reperfusion Injury in Male Rats. SRP. 2019; 10(1): 206-213. doi:10.5530/srp.2019.1.36


Web Style

LMAA, RHA, SMH, Hadi NR. DMF Ameliorating Cerebral Ischemia/ Reperfusion Injury in Male Rats. http://www.sysrevpharm.org//?mno=302644974 [Access: June 03, 2020]. doi:10.5530/srp.2019.1.36


AMA (American Medical Association) Style

LMAA, RHA, SMH, Hadi NR. DMF Ameliorating Cerebral Ischemia/ Reperfusion Injury in Male Rats. SRP. 2019; 10(1): 206-213. doi:10.5530/srp.2019.1.36



Vancouver/ICMJE Style

LMAA, RHA, SMH, Hadi NR. DMF Ameliorating Cerebral Ischemia/ Reperfusion Injury in Male Rats. SRP. (2019), [cited June 03, 2020]; 10(1): 206-213. doi:10.5530/srp.2019.1.36



Harvard Style

, L. M. A. A., , . R. H. A., , . S. M. H. & Hadi, . N. R. (2019) DMF Ameliorating Cerebral Ischemia/ Reperfusion Injury in Male Rats. SRP, 10 (1), 206-213. doi:10.5530/srp.2019.1.36



Turabian Style

, Laith M Abbas Al-Huseini, Rihab H Al-Mudhaffer, Saif M Hassan, and Najah R Hadi. 2019. DMF Ameliorating Cerebral Ischemia/ Reperfusion Injury in Male Rats. Systematic Reviews in Pharmacy, 10 (1), 206-213. doi:10.5530/srp.2019.1.36



Chicago Style

, Laith M Abbas Al-Huseini, Rihab H Al-Mudhaffer, Saif M Hassan, and Najah R Hadi. "DMF Ameliorating Cerebral Ischemia/ Reperfusion Injury in Male Rats." Systematic Reviews in Pharmacy 10 (2019), 206-213. doi:10.5530/srp.2019.1.36



MLA (The Modern Language Association) Style

, Laith M Abbas Al-Huseini, Rihab H Al-Mudhaffer, Saif M Hassan, and Najah R Hadi. "DMF Ameliorating Cerebral Ischemia/ Reperfusion Injury in Male Rats." Systematic Reviews in Pharmacy 10.1 (2019), 206-213. Print. doi:10.5530/srp.2019.1.36



APA (American Psychological Association) Style

, L. M. A. A., , . R. H. A., , . S. M. H. & Hadi, . N. R. (2019) DMF Ameliorating Cerebral Ischemia/ Reperfusion Injury in Male Rats. Systematic Reviews in Pharmacy, 10 (1), 206-213. doi:10.5530/srp.2019.1.36





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