E-ISSN 0976-2779 | ISSN 0975-8453
 

Review Article 


TYPE 2 DIABETES MELLITUS IN PATIENTS WITH CHRONIC VIRAL HEPATITIS C AND B

NIGORA AKESHOVA, GAUKHAR KURMANOVA, ARZU & 1052;AMUTOVA, ALMAGUL KURMANOVA, IKILAS MOLDALIEV.

Abstract
Summary. A number of clinical and population-based studies have shown a link between the development of insulin resistance and type 2 diabetes mellitus and hepatitis C.
Purpose of research: to study the frequency of type 2 diabetes mellitus and its course in patients with chronic viral hepatitis C and B during antiviral therapy.
Material and methods: 213 patients (164 with CVH C, 34 with CVH B and 15 with CVH B + C) were examined before and in the course of treatment. All patients received standard antiviral therapy. In patients with type 2 diabetes, the level of fasting glycemia was determined daily in the first 8-12 weeks of treatment. The level of glycemia was determined at the laboratory at least once every 2 weeks. Glycated hemoglobin was determined every 3 months during treatment and another 6 months after completion of the antiviral therapy.
Results: In the group of patients with CVH C, type 2 diabetes mellitus occurred 2 times more often (13.4%) than in groups with CVH B (6.1%) with a reliability of p <0.01. With HCV genotype 3 is 2.5 times more often than with genotype 1 (p <0.001). Among patients, type 2 diabetes is 2.5 times more often men than women (p <0.01). Upon reaching an early virological response in 77.3% of patients, the level of glycemia returned to normal. The correlation coefficient between the achievement of a full virological response (negative PCR results on HCV RNA) and the normalization of the level of glycemia was 0.75. Glycemia control was maintained for 6 months after the completion of the antiviral therapy in the background of a persistent virological response.
Conclusions: The presence of diabetes is the basis for screening for HCV, regardless of other factors. 75-77% of type 2 diabetes mellitus in the cohort of patients with CVH C is possibly virus-associated. Treatment of HCV infection can lead to a cure for type 2 diabetes mellitus in this category of patients.

Key words: viral hepatitis C, genotype 3, type 2 diabetes mellitus.


 
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Pubmed Style

, MOLDALIEV AAKI. TYPE 2 DIABETES MELLITUS IN PATIENTS WITH CHRONIC VIRAL HEPATITIS C AND B. SRP. 2019; 10(2): 284-289. doi:10.5530/srp.2019.2.38


Web Style

, MOLDALIEV AAKI. TYPE 2 DIABETES MELLITUS IN PATIENTS WITH CHRONIC VIRAL HEPATITIS C AND B. http://www.sysrevpharm.org//?mno=302645091 [Access: February 18, 2020]. doi:10.5530/srp.2019.2.38


AMA (American Medical Association) Style

, MOLDALIEV AAKI. TYPE 2 DIABETES MELLITUS IN PATIENTS WITH CHRONIC VIRAL HEPATITIS C AND B. SRP. 2019; 10(2): 284-289. doi:10.5530/srp.2019.2.38



Vancouver/ICMJE Style

, MOLDALIEV AAKI. TYPE 2 DIABETES MELLITUS IN PATIENTS WITH CHRONIC VIRAL HEPATITIS C AND B. SRP. (2019), [cited February 18, 2020]; 10(2): 284-289. doi:10.5530/srp.2019.2.38



Harvard Style

& MOLDALIEV, A. A. K. I. (2019) TYPE 2 DIABETES MELLITUS IN PATIENTS WITH CHRONIC VIRAL HEPATITIS C AND B. SRP, 10 (2), 284-289. doi:10.5530/srp.2019.2.38



Turabian Style

, and AMUTOVA, ALMAGUL KURMANOVA, IKILAS MOLDALIEV. 2019. TYPE 2 DIABETES MELLITUS IN PATIENTS WITH CHRONIC VIRAL HEPATITIS C AND B. Systematic Reviews in Pharmacy, 10 (2), 284-289. doi:10.5530/srp.2019.2.38



Chicago Style

, and AMUTOVA, ALMAGUL KURMANOVA, IKILAS MOLDALIEV. "TYPE 2 DIABETES MELLITUS IN PATIENTS WITH CHRONIC VIRAL HEPATITIS C AND B." Systematic Reviews in Pharmacy 10 (2019), 284-289. doi:10.5530/srp.2019.2.38



MLA (The Modern Language Association) Style

, and AMUTOVA, ALMAGUL KURMANOVA, IKILAS MOLDALIEV. "TYPE 2 DIABETES MELLITUS IN PATIENTS WITH CHRONIC VIRAL HEPATITIS C AND B." Systematic Reviews in Pharmacy 10.2 (2019), 284-289. Print. doi:10.5530/srp.2019.2.38



APA (American Psychological Association) Style

& MOLDALIEV, A. A. K. I. (2019) TYPE 2 DIABETES MELLITUS IN PATIENTS WITH CHRONIC VIRAL HEPATITIS C AND B. Systematic Reviews in Pharmacy, 10 (2), 284-289. doi:10.5530/srp.2019.2.38





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