E-ISSN 0976-2779 | ISSN 0975-8453
 

Review Article 


Histological Study of Therapeutic Effect of P.ostreatus on Gastric Ulcer in Male Rats

MOHAMMED JUBAIR HANAWI, SAJA HUSSAIN DILFI, ADNAN W. M. AL-BIDERI.

Abstract
Mushrooms extract have wide range of medical activity. Present study goaled to investigate healing role of P.ostrateus on aspirin induced gastric ulcer. This study carried out on rats males of Rattus norvegicus, rats divided into negative control group(C), positive control group (T1), standard drug treated control group (T2), group treated with alcoholic extract of P.ostreatus (T3),group treated with polysaccharide of P.ostreatus (T4) and group treated with chitin and chitosan of p. ostreatus (T5). Histopathological examination of stomach tissue by hematoxylin and eosin, Periodic acid Schiff and Masson's trichrome of P.ostreatus extract treated group (T3) at the end of the 10 day of treatment showed epithelial cell reconstitution and gastric cell repair in gastric mucosa accompanied with marked infiltration of leucocytes and congestion in the walls of the blood vessels of the submucosal layer.
At the end of 20 days, it was observed the gastric mucosa was closely no major differences compared with normal group and had better healing effect than that of omeprazole group. Histological observation of the animals treated with Polysaccharide, Chitin and Chitosan of P.ostrateus (T5 and T4) showed moderate disruption of the surface epithelium with leucocyte infiltration and thickening of muscularis mucosae at the first period. At second period there is still mild disruption and the repair is not complete. Present study detected a significant role of P.ostreatus extract in gastric ulcer healing.

Key words: P.ostrateus, Aspirin, Gastric Ulcer, Omeprazole


 
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Pubmed Style

MOHAMMED JUBAIR HANAWI, SAJA HUSSAIN DILFI, ADNAN W. M. AL-BIDERI. Histological Study of Therapeutic Effect of P.ostreatus on Gastric Ulcer in Male Rats. SRP. 2020; 11(1): 26-34. doi:10.5530/srp.2020.1.05


Web Style

MOHAMMED JUBAIR HANAWI, SAJA HUSSAIN DILFI, ADNAN W. M. AL-BIDERI. Histological Study of Therapeutic Effect of P.ostreatus on Gastric Ulcer in Male Rats. http://www.sysrevpharm.org//?mno=302645216 [Access: January 17, 2020]. doi:10.5530/srp.2020.1.05


AMA (American Medical Association) Style

MOHAMMED JUBAIR HANAWI, SAJA HUSSAIN DILFI, ADNAN W. M. AL-BIDERI. Histological Study of Therapeutic Effect of P.ostreatus on Gastric Ulcer in Male Rats. SRP. 2020; 11(1): 26-34. doi:10.5530/srp.2020.1.05



Vancouver/ICMJE Style

MOHAMMED JUBAIR HANAWI, SAJA HUSSAIN DILFI, ADNAN W. M. AL-BIDERI. Histological Study of Therapeutic Effect of P.ostreatus on Gastric Ulcer in Male Rats. SRP. (2020), [cited January 17, 2020]; 11(1): 26-34. doi:10.5530/srp.2020.1.05



Harvard Style

MOHAMMED JUBAIR HANAWI, SAJA HUSSAIN DILFI, ADNAN W. M. AL-BIDERI (2020) Histological Study of Therapeutic Effect of P.ostreatus on Gastric Ulcer in Male Rats. SRP, 11 (1), 26-34. doi:10.5530/srp.2020.1.05



Turabian Style

MOHAMMED JUBAIR HANAWI, SAJA HUSSAIN DILFI, ADNAN W. M. AL-BIDERI. 2020. Histological Study of Therapeutic Effect of P.ostreatus on Gastric Ulcer in Male Rats. Systematic Reviews in Pharmacy, 11 (1), 26-34. doi:10.5530/srp.2020.1.05



Chicago Style

MOHAMMED JUBAIR HANAWI, SAJA HUSSAIN DILFI, ADNAN W. M. AL-BIDERI. "Histological Study of Therapeutic Effect of P.ostreatus on Gastric Ulcer in Male Rats." Systematic Reviews in Pharmacy 11 (2020), 26-34. doi:10.5530/srp.2020.1.05



MLA (The Modern Language Association) Style

MOHAMMED JUBAIR HANAWI, SAJA HUSSAIN DILFI, ADNAN W. M. AL-BIDERI. "Histological Study of Therapeutic Effect of P.ostreatus on Gastric Ulcer in Male Rats." Systematic Reviews in Pharmacy 11.1 (2020), 26-34. Print. doi:10.5530/srp.2020.1.05



APA (American Psychological Association) Style

MOHAMMED JUBAIR HANAWI, SAJA HUSSAIN DILFI, ADNAN W. M. AL-BIDERI (2020) Histological Study of Therapeutic Effect of P.ostreatus on Gastric Ulcer in Male Rats. Systematic Reviews in Pharmacy, 11 (1), 26-34. doi:10.5530/srp.2020.1.05





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