E-ISSN 0976-2779 | ISSN 0975-8453
 

Review Article 


Evaluation Gene Expression of Stem Cell Factor and C-kit among Bronchial Asthmatic patients

NAWRAS NAJAH MUBARK, JAFAR A. AL-MAAMORI, KAREEM HAMED GHALI.

Abstract
Background: Mast cells play an essential role in pathology of bronchial asthma. Stem cell factor (SCF) is a major mast cell growth factor, which could be involved in the local increase of mast cell number in the asthmatic airways when bind to its receptor (C-kit). Existing study aimed to evaluate role of gene expression of SCF and their receptor C-kit in development of bronchial asthma in Iraqi population.
Methods: present study included 100 patients diagnostic with bronchial asthma (59 females and 41 males) their ages range from 2 to 61 years and 30 healthy individuals (14 females and 16 males) with the same age range as control group DNA extracted from whole blood samples and then subjected to real time PCR for detection of gene expression.
Results: current data showed a significant correlation (p<0.05) between SCF, C-kit and asthma when high gene expression (mean of folding change ) are appeared in asthmatic patients (5.20 and 4.03 respectively) compared to healthy control groups (1.00) . In present study, the highest gene expression of SCF and its receptor c-kit were appeared in sever persist asthma, moderate persist asthma and mild persist groups. Moreover, SCF and C-kit expression was influenced by treatment (3.54 and 3.63 respectively) in compared with untreated cases (3.78 and 4.97) (p>0.05) . The optimum cut-off values for gene expression of SCF and C-kit are ≥ 0.55, ≥2.328 respectively since there are associated with a perfect test for predicting asthma.
In conclusion: high gene expression of SCF and C-kit associated with increase severity stage of bronchial asthma without treatment and can be reduced by treatment.

Key words: Asthma, SCF, C-kit, gene expression


 
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How to Cite this Article
Pubmed Style

MUBARK NN, AL-MAAMORI JA, GHALI KH. Evaluation Gene Expression of Stem Cell Factor and C-kit among Bronchial Asthmatic patients. SRP. 2020; 11(1): 51-57. doi:10.5530/srp.2020.1.08


Web Style

MUBARK NN, AL-MAAMORI JA, GHALI KH. Evaluation Gene Expression of Stem Cell Factor and C-kit among Bronchial Asthmatic patients. http://www.sysrevpharm.org//?mno=302645230 [Access: February 23, 2020]. doi:10.5530/srp.2020.1.08


AMA (American Medical Association) Style

MUBARK NN, AL-MAAMORI JA, GHALI KH. Evaluation Gene Expression of Stem Cell Factor and C-kit among Bronchial Asthmatic patients. SRP. 2020; 11(1): 51-57. doi:10.5530/srp.2020.1.08



Vancouver/ICMJE Style

MUBARK NN, AL-MAAMORI JA, GHALI KH. Evaluation Gene Expression of Stem Cell Factor and C-kit among Bronchial Asthmatic patients. SRP. (2020), [cited February 23, 2020]; 11(1): 51-57. doi:10.5530/srp.2020.1.08



Harvard Style

MUBARK, N. N., AL-MAAMORI, . J. A. & GHALI, . K. H. (2020) Evaluation Gene Expression of Stem Cell Factor and C-kit among Bronchial Asthmatic patients. SRP, 11 (1), 51-57. doi:10.5530/srp.2020.1.08



Turabian Style

MUBARK, NAWRAS NAJAH, JAFAR A. AL-MAAMORI, and KAREEM HAMED GHALI. 2020. Evaluation Gene Expression of Stem Cell Factor and C-kit among Bronchial Asthmatic patients. Systematic Reviews in Pharmacy, 11 (1), 51-57. doi:10.5530/srp.2020.1.08



Chicago Style

MUBARK, NAWRAS NAJAH, JAFAR A. AL-MAAMORI, and KAREEM HAMED GHALI. "Evaluation Gene Expression of Stem Cell Factor and C-kit among Bronchial Asthmatic patients." Systematic Reviews in Pharmacy 11 (2020), 51-57. doi:10.5530/srp.2020.1.08



MLA (The Modern Language Association) Style

MUBARK, NAWRAS NAJAH, JAFAR A. AL-MAAMORI, and KAREEM HAMED GHALI. "Evaluation Gene Expression of Stem Cell Factor and C-kit among Bronchial Asthmatic patients." Systematic Reviews in Pharmacy 11.1 (2020), 51-57. Print. doi:10.5530/srp.2020.1.08



APA (American Psychological Association) Style

MUBARK, N. N., AL-MAAMORI, . J. A. & GHALI, . K. H. (2020) Evaluation Gene Expression of Stem Cell Factor and C-kit among Bronchial Asthmatic patients. Systematic Reviews in Pharmacy, 11 (1), 51-57. doi:10.5530/srp.2020.1.08





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