E-ISSN 0976-2779 | ISSN 0975-8453
 

Review Article 


Inhibition of Type I Collagen Expression in Fibrosis Prevention after Trabeculectomy: Oryctolagus cuniculus

Nurwasis.

Abstract
The administration of postoperative bevacizumab injection in subconjunctival trabeculectomy will reduce bleb fibrosis. This study aimed to investigate the effect of bevacizumab as an antifibrotic agent on collagen density, collagen thickness and type I collagen expression after trabeculectomy in rabbits. Sixteen males New Zealand white rabbits were divided into two groups, control and treatment group. Masson’s trichrome was performed to evaluate collagen density and thickness. Immunohistochemistry examination using a monoclonal antibody to type I collagen was performed to evaluate collagen expression. Among the sixteen samples, postoperative bleb conditions obtained diffuse bleb, and there were no differences in bleb characteristics between the control and treatment groups. Anterior chamber was deep, and cornea was clear in all animals. This study showed that the density of collagen fibers and type 1 collagen expression significantly decreased in the treatment group compared to control group (p = 0.0075; p = 0.006, respectively). However, there was no significant difference in the thickness of collagen fibers in both groups (p = 0.323). Bevacizumab reduces bleb fibrosis by inhibition of angiogenesis and accumulation of extracellular matrix. Postoperative subconjunctival injection of bevacizumab may limit scar tissue formation at the site of trabeculectomy by blocking collagen synthesis.

Key words: Bevacizumab, trabeculectomy, fibrosis, collagen type I


 
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Pubmed Style

Nurwasis. Inhibition of Type I Collagen Expression in Fibrosis Prevention after Trabeculectomy: Oryctolagus cuniculus. SRP. 2020; 11(6): 972-978. doi:10.31838/srp.2020.6.137


Web Style

Nurwasis. Inhibition of Type I Collagen Expression in Fibrosis Prevention after Trabeculectomy: Oryctolagus cuniculus. http://www.sysrevpharm.org//?mno=30444 [Access: July 07, 2020]. doi:10.31838/srp.2020.6.137


AMA (American Medical Association) Style

Nurwasis. Inhibition of Type I Collagen Expression in Fibrosis Prevention after Trabeculectomy: Oryctolagus cuniculus. SRP. 2020; 11(6): 972-978. doi:10.31838/srp.2020.6.137



Vancouver/ICMJE Style

Nurwasis. Inhibition of Type I Collagen Expression in Fibrosis Prevention after Trabeculectomy: Oryctolagus cuniculus. SRP. (2020), [cited July 07, 2020]; 11(6): 972-978. doi:10.31838/srp.2020.6.137



Harvard Style

Nurwasis (2020) Inhibition of Type I Collagen Expression in Fibrosis Prevention after Trabeculectomy: Oryctolagus cuniculus. SRP, 11 (6), 972-978. doi:10.31838/srp.2020.6.137



Turabian Style

Nurwasis. 2020. Inhibition of Type I Collagen Expression in Fibrosis Prevention after Trabeculectomy: Oryctolagus cuniculus. Systematic Reviews in Pharmacy, 11 (6), 972-978. doi:10.31838/srp.2020.6.137



Chicago Style

Nurwasis. "Inhibition of Type I Collagen Expression in Fibrosis Prevention after Trabeculectomy: Oryctolagus cuniculus." Systematic Reviews in Pharmacy 11 (2020), 972-978. doi:10.31838/srp.2020.6.137



MLA (The Modern Language Association) Style

Nurwasis. "Inhibition of Type I Collagen Expression in Fibrosis Prevention after Trabeculectomy: Oryctolagus cuniculus." Systematic Reviews in Pharmacy 11.6 (2020), 972-978. Print. doi:10.31838/srp.2020.6.137



APA (American Psychological Association) Style

Nurwasis (2020) Inhibition of Type I Collagen Expression in Fibrosis Prevention after Trabeculectomy: Oryctolagus cuniculus. Systematic Reviews in Pharmacy, 11 (6), 972-978. doi:10.31838/srp.2020.6.137





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