E-ISSN 0976-2779 | ISSN 0975-8453
 

Review Article 


Salivary Levels Of Interleukin-1beta, Tumour Necrosis Factor-, And C-Reactive Proteins In Smokers Patients With Severe Chronic Periodontitis

Bayan Jabr Hussein, Issa Hasan Issa, Ansam Mahdi Khaleel, Najlaa Abdulameer Ali AL-Dahhan.

Abstract
Background. Chronic periodontitis(CP) is disease that causes loss of the supporting structures of teeth, cementum, alveolar bone and periodontal ligaments. Cytokines are important mediators of immune responses. Interleukins play a major role in gum disease and can be used as diagnostic markers. Objectives. To determine salivary IL-1β and TNF- levels in smokers patients with severe CP. And to assess the association between development of PD and the salivary expression of IL-1β and TNF-.Materials and Methods. Salivary levels of IL-1β and TNF- evaluated using an ELISA assay. Results. In non-smokers, significant differences were observed between CP patients and HC(P=0.062).While in smokers, A significant differences were observed between CP patients and HC (p=0.004).There were significant difference in CRP between the two groups(p=0.027). A Statistically significant difference was observed in gingival health between the two groups, as assessed by CPITN(p=0.006).A statistically significant increase in salivary levels of Interleukin-1β and TNF- was observed in patients with the severe CP than with controls(p<0.001).In patients with severe CP,the correlation between CRP with IL-1β and TNF- were positive with statistically significant (p=0.027, p=0.008),respectively.Similarly a statistically significant positive correlation was observed between smoking with IL -1β and TNF-(p=0.012,p=0.001),respectively. Apositive association observed between pro-inflammatory cytokines identified in this study.Conclusion.Salivary IL-1β and TNF- levels were significantly elevated in severe CP patients compared to healthy controls. These levels increased with the development of the CP and inflammation in smokers patients compared to non-smokers. The association of these interleukins is more common in CP patients who smoke compared to non-smokers.

Key words: Severe chronic periodontitis, Interleukin-1beta, Inflammation,Tumour Necrosis Factor-α .


 
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How to Cite this Article
Pubmed Style

Hussein BJ, Issa IH, Khaleel AM, AL-Dahhan NAA. Salivary Levels Of Interleukin-1beta, Tumour Necrosis Factor-, And C-Reactive Proteins In Smokers Patients With Severe Chronic Periodontitis. SRP. 2021; 12(2): 242-247. doi:10.31838/srp.2021.2.30


Web Style

Hussein BJ, Issa IH, Khaleel AM, AL-Dahhan NAA. Salivary Levels Of Interleukin-1beta, Tumour Necrosis Factor-, And C-Reactive Proteins In Smokers Patients With Severe Chronic Periodontitis. http://www.sysrevpharm.org/?mno=30938 [Access: January 22, 2021]. doi:10.31838/srp.2021.2.30


AMA (American Medical Association) Style

Hussein BJ, Issa IH, Khaleel AM, AL-Dahhan NAA. Salivary Levels Of Interleukin-1beta, Tumour Necrosis Factor-, And C-Reactive Proteins In Smokers Patients With Severe Chronic Periodontitis. SRP. 2021; 12(2): 242-247. doi:10.31838/srp.2021.2.30



Vancouver/ICMJE Style

Hussein BJ, Issa IH, Khaleel AM, AL-Dahhan NAA. Salivary Levels Of Interleukin-1beta, Tumour Necrosis Factor-, And C-Reactive Proteins In Smokers Patients With Severe Chronic Periodontitis. SRP. (2021), [cited January 22, 2021]; 12(2): 242-247. doi:10.31838/srp.2021.2.30



Harvard Style

Hussein, B. J., Issa, . I. H., Khaleel, . A. M. & AL-Dahhan, . N. A. A. (2021) Salivary Levels Of Interleukin-1beta, Tumour Necrosis Factor-, And C-Reactive Proteins In Smokers Patients With Severe Chronic Periodontitis. SRP, 12 (2), 242-247. doi:10.31838/srp.2021.2.30



Turabian Style

Hussein, Bayan Jabr, Issa Hasan Issa, Ansam Mahdi Khaleel, and Najlaa Abdulameer Ali AL-Dahhan. 2021. Salivary Levels Of Interleukin-1beta, Tumour Necrosis Factor-, And C-Reactive Proteins In Smokers Patients With Severe Chronic Periodontitis. Systematic Reviews in Pharmacy, 12 (2), 242-247. doi:10.31838/srp.2021.2.30



Chicago Style

Hussein, Bayan Jabr, Issa Hasan Issa, Ansam Mahdi Khaleel, and Najlaa Abdulameer Ali AL-Dahhan. "Salivary Levels Of Interleukin-1beta, Tumour Necrosis Factor-, And C-Reactive Proteins In Smokers Patients With Severe Chronic Periodontitis." Systematic Reviews in Pharmacy 12 (2021), 242-247. doi:10.31838/srp.2021.2.30



MLA (The Modern Language Association) Style

Hussein, Bayan Jabr, Issa Hasan Issa, Ansam Mahdi Khaleel, and Najlaa Abdulameer Ali AL-Dahhan. "Salivary Levels Of Interleukin-1beta, Tumour Necrosis Factor-, And C-Reactive Proteins In Smokers Patients With Severe Chronic Periodontitis." Systematic Reviews in Pharmacy 12.2 (2021), 242-247. Print. doi:10.31838/srp.2021.2.30



APA (American Psychological Association) Style

Hussein, B. J., Issa, . I. H., Khaleel, . A. M. & AL-Dahhan, . N. A. A. (2021) Salivary Levels Of Interleukin-1beta, Tumour Necrosis Factor-, And C-Reactive Proteins In Smokers Patients With Severe Chronic Periodontitis. Systematic Reviews in Pharmacy, 12 (2), 242-247. doi:10.31838/srp.2021.2.30





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