Potential Protective Effect Of Quercetin Against Cisplatin-Induced Acute Nephrotoxicity In Male Rats

Salim Kadhim| Mohammed Al-Rekabi| Nisreen Mohammed and Batool Al Khafaji

Review Article

SRP. 2021; 12(2): 248-252

doi: 10.31838/srp.2021.2.31

Potential Protective Effect Of Quercetin Against Cisplatin-Induced Acute Nephrotoxicity In Male Rats

Salim Kadhim, Mohammed Al-Rekabi, Nisreen Mohammed and Batool Al Khafaji.

Abstract
Cisplatin-induced nephrotoxicity is a significant dose limiting side effect. We investigated the possible nephroprotective effect of quercetin before and after inducing acute renal damage using cisplatin in male rats. Cisplatin administration resulted in renal damage represented by the elevated renal function parameters, elevated oxidative stress and inflammatory markers, and diminished production of the antioxidant marker. Treatment with quercetin showed reduced levels of renal function parameters, improved antioxidant status, and reduced levels of MDA and TNF-Î±. This study revealed a potential role of quercetin in protection against cisplatin-induced nephrotoxicity.

Key words: Cisplatin, quercetin, nephrotoxicity, oxidative stress, lipid peroxidation, GSH, MDA, TNF-Î±.

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Pubmed Style

Kadhim S, Al-Rekabi M, . Potential Protective Effect Of Quercetin Against Cisplatin-Induced Acute Nephrotoxicity In Male Rats. SRP. 2021; 12(2): 248-252. doi:10.31838/srp.2021.2.31

Web Style

Kadhim S, Al-Rekabi M, . Potential Protective Effect Of Quercetin Against Cisplatin-Induced Acute Nephrotoxicity In Male Rats. http://www.sysrevpharm.org/?mno=30940 [Access: January 18, 2021]. doi:10.31838/srp.2021.2.31

AMA (American Medical Association) Style

Kadhim S, Al-Rekabi M, . Potential Protective Effect Of Quercetin Against Cisplatin-Induced Acute Nephrotoxicity In Male Rats. SRP. 2021; 12(2): 248-252. doi:10.31838/srp.2021.2.31

Vancouver/ICMJE Style

Kadhim S, Al-Rekabi M, . Potential Protective Effect Of Quercetin Against Cisplatin-Induced Acute Nephrotoxicity In Male Rats. SRP. (2021), [cited January 18, 2021]; 12(2): 248-252. doi:10.31838/srp.2021.2.31

Harvard Style

Kadhim, S., Al-Rekabi, . M. & (2021) Potential Protective Effect Of Quercetin Against Cisplatin-Induced Acute Nephrotoxicity In Male Rats. SRP, 12 (2), 248-252. doi:10.31838/srp.2021.2.31

Turabian Style

Kadhim, Salim, Mohammed Al-Rekabi, and Nisreen Mohammed and Batool Al Khafaji. 2021. Potential Protective Effect Of Quercetin Against Cisplatin-Induced Acute Nephrotoxicity In Male Rats. Systematic Reviews in Pharmacy, 12 (2), 248-252. doi:10.31838/srp.2021.2.31

Chicago Style

Kadhim, Salim, Mohammed Al-Rekabi, and Nisreen Mohammed and Batool Al Khafaji. "Potential Protective Effect Of Quercetin Against Cisplatin-Induced Acute Nephrotoxicity In Male Rats." Systematic Reviews in Pharmacy 12 (2021), 248-252. doi:10.31838/srp.2021.2.31

MLA (The Modern Language Association) Style

APA (American Psychological Association) Style

Kadhim, S., Al-Rekabi, . M. & (2021) Potential Protective Effect Of Quercetin Against Cisplatin-Induced Acute Nephrotoxicity In Male Rats. Systematic Reviews in Pharmacy, 12 (2), 248-252. doi:10.31838/srp.2021.2.31

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