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2021, Vol: 12, Issue: 2
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Review Article 


Synthesis, Characterization and Antioxidant Activity of Some New Schiff base Derived from Cytosine

Ali A. Mahmood, Farah. Kh. H. Al-Juboory, Hala M. Garib Al–Zahwi.

Abstract
Cytosine is used to synthesize several derivatives of Schiff base when reacted with some aldehydes which are refluxed by using ethanol as a solvent and non solvent with adomestic microwave (Compounds A1 – A4). These products of the Schiff base are treated first with chloroacetyl chloride to synthesize four-membered heterocycles (Compounds B1 – B4). After that, they treated with hydroxyl acetic acid to synthesize five-membered heterocyclic (Compounds C1 – C4). In the third step, the products are used to react with amaleic acid anhydride to produce seven-membered heterocyclic (Compound D1 – D4). The antioxidant activity of the compounds (A1 – A4) and two of the compounds (B1, B3), (C1, C3) and (D1, D3) in different concentrations of (100, 200, 300, 400 and 500 mg/ml) are tested with 1,2 – Di Phenyl – 2 – Picryl Hydrazyl (DPPH) for scavenging a radical activity. Finally, these compounds are diagnosed by several technical devices such as IR, proton1HN.M. R and13C N.M.R. spectroscopy.

Key words: Synthesis; Cytosine; Schiff Base; Antioxidant; % DPPH Radical Scavenging Activity.


 
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How to Cite this Article
Pubmed Style

Ali A. Mahmood, Farah. Kh. H. Al-Juboory, Hala M. Garib Al-Zahwi. Synthesis, Characterization and Antioxidant Activity of Some New Schiff base Derived from Cytosine. SRP. 2021; 12(2): 323-335. doi:10.31838/srp.2021.2.44

Web Style

Ali A. Mahmood, Farah. Kh. H. Al-Juboory, Hala M. Garib Al-Zahwi. Synthesis, Characterization and Antioxidant Activity of Some New Schiff base Derived from Cytosine. http://www.sysrevpharm.org/?mno=35021 [Access: January 22, 2021]. doi:10.31838/srp.2021.2.44

AMA (American Medical Association) Style

Ali A. Mahmood, Farah. Kh. H. Al-Juboory, Hala M. Garib Al-Zahwi. Synthesis, Characterization and Antioxidant Activity of Some New Schiff base Derived from Cytosine. SRP. 2021; 12(2): 323-335. doi:10.31838/srp.2021.2.44


Vancouver/ICMJE Style

Ali A. Mahmood, Farah. Kh. H. Al-Juboory, Hala M. Garib Al-Zahwi. Synthesis, Characterization and Antioxidant Activity of Some New Schiff base Derived from Cytosine. SRP. (2021), [cited January 22, 2021]; 12(2): 323-335. doi:10.31838/srp.2021.2.44


Harvard Style

Ali A. Mahmood, Farah. Kh. H. Al-Juboory, Hala M. Garib Al-Zahwi (2021) Synthesis, Characterization and Antioxidant Activity of Some New Schiff base Derived from Cytosine. SRP, 12 (2), 323-335. doi:10.31838/srp.2021.2.44


Turabian Style

Ali A. Mahmood, Farah. Kh. H. Al-Juboory, Hala M. Garib Al-Zahwi. 2021. Synthesis, Characterization and Antioxidant Activity of Some New Schiff base Derived from Cytosine. Systematic Reviews in Pharmacy, 12 (2), 323-335. doi:10.31838/srp.2021.2.44


Chicago Style

Ali A. Mahmood, Farah. Kh. H. Al-Juboory, Hala M. Garib Al-Zahwi. "Synthesis, Characterization and Antioxidant Activity of Some New Schiff base Derived from Cytosine." Systematic Reviews in Pharmacy 12 (2021), 323-335. doi:10.31838/srp.2021.2.44


MLA (The Modern Language Association) Style

Ali A. Mahmood, Farah. Kh. H. Al-Juboory, Hala M. Garib Al-Zahwi. "Synthesis, Characterization and Antioxidant Activity of Some New Schiff base Derived from Cytosine." Systematic Reviews in Pharmacy 12.2 (2021), 323-335. Print. doi:10.31838/srp.2021.2.44


APA (American Psychological Association) Style

Ali A. Mahmood, Farah. Kh. H. Al-Juboory, Hala M. Garib Al-Zahwi (2021) Synthesis, Characterization and Antioxidant Activity of Some New Schiff base Derived from Cytosine. Systematic Reviews in Pharmacy, 12 (2), 323-335. doi:10.31838/srp.2021.2.44




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