E-ISSN 0976-2779 | ISSN 0975-8453
 

Review Article 


The Effect Of Ketamine On Ventilator Isolation In Patients With Agitated Delirium In Comparison With Standard Care

Alireza Kamali, Behnam Mahmodiyeh, Seyed Mohammad Jamalian, Mohadeseh Esmaeili.

Abstract
Introduction: Agitated delirium causes more problems, especially in patients with mechanical ventilation, due to the increased risk of self extubation. Therefore, recognizing and introducing the delirium time-reducing drug in the treatment process of these patients will be very important.
Materials and Methods: This clinical trial study was performed on 64 patients undergoing ventilator with agitated delirium (RASS≥3) admitted to the intensive care unit of Valiasr Hospital in Arak. These patients were divided into two groups using a random number table. Patients in the ketamine group were given 1-2 mg/h of ketamine daily, and patients in the propofol group received propofol as an infusion. the Tnformation obtained from these patients was recorded in a checklist. Finally, this information was analyzed using SPSS 19.
Results: The mean age (SD) of the ketamine and propofol groups were 39.63 (12.65) and 41.09 (11.81), respectively. There was no significant difference between the two groups in terms of age and gender. There was no significant difference between the two groups in terms of hemodynamic changes during the study period (P> 0.05). The mean (SD) duration of intubation in the ketamine and propofol groups was 82.72±8.73) and 179.81±8.46 hours, respectively (P <0.0001).
RASS and pain decreased significantly more rapidly (P <0.0001) in the ketamine group over three days. Conclusion: The use of ketamine was capable of reducing the duration of intubation, pain and agitation of the patient with agitated delirium hospitalized in the intensive care unit while it does not cause hemodynamic changes for the patient.

Key words: Ketamine, ventilator isolation, agitated delirium, standard care.


 
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How to Cite this Article
Pubmed Style

Alireza Kamali, Behnam Mahmodiyeh, Seyed Mohammad Jamalian, Mohadeseh Esmaeili. The Effect Of Ketamine On Ventilator Isolation In Patients With Agitated Delirium In Comparison With Standard Care. SRP. 2021; 12(3): 84-87. doi:10.31838/srp.2021.3.15


Web Style

Alireza Kamali, Behnam Mahmodiyeh, Seyed Mohammad Jamalian, Mohadeseh Esmaeili. The Effect Of Ketamine On Ventilator Isolation In Patients With Agitated Delirium In Comparison With Standard Care. http://www.sysrevpharm.org/?mno=51505 [Access: March 04, 2021]. doi:10.31838/srp.2021.3.15


AMA (American Medical Association) Style

Alireza Kamali, Behnam Mahmodiyeh, Seyed Mohammad Jamalian, Mohadeseh Esmaeili. The Effect Of Ketamine On Ventilator Isolation In Patients With Agitated Delirium In Comparison With Standard Care. SRP. 2021; 12(3): 84-87. doi:10.31838/srp.2021.3.15



Vancouver/ICMJE Style

Alireza Kamali, Behnam Mahmodiyeh, Seyed Mohammad Jamalian, Mohadeseh Esmaeili. The Effect Of Ketamine On Ventilator Isolation In Patients With Agitated Delirium In Comparison With Standard Care. SRP. (2021), [cited March 04, 2021]; 12(3): 84-87. doi:10.31838/srp.2021.3.15



Harvard Style

Alireza Kamali, Behnam Mahmodiyeh, Seyed Mohammad Jamalian, Mohadeseh Esmaeili (2021) The Effect Of Ketamine On Ventilator Isolation In Patients With Agitated Delirium In Comparison With Standard Care. SRP, 12 (3), 84-87. doi:10.31838/srp.2021.3.15



Turabian Style

Alireza Kamali, Behnam Mahmodiyeh, Seyed Mohammad Jamalian, Mohadeseh Esmaeili. 2021. The Effect Of Ketamine On Ventilator Isolation In Patients With Agitated Delirium In Comparison With Standard Care. Systematic Reviews in Pharmacy, 12 (3), 84-87. doi:10.31838/srp.2021.3.15



Chicago Style

Alireza Kamali, Behnam Mahmodiyeh, Seyed Mohammad Jamalian, Mohadeseh Esmaeili. "The Effect Of Ketamine On Ventilator Isolation In Patients With Agitated Delirium In Comparison With Standard Care." Systematic Reviews in Pharmacy 12 (2021), 84-87. doi:10.31838/srp.2021.3.15



MLA (The Modern Language Association) Style

Alireza Kamali, Behnam Mahmodiyeh, Seyed Mohammad Jamalian, Mohadeseh Esmaeili. "The Effect Of Ketamine On Ventilator Isolation In Patients With Agitated Delirium In Comparison With Standard Care." Systematic Reviews in Pharmacy 12.3 (2021), 84-87. Print. doi:10.31838/srp.2021.3.15



APA (American Psychological Association) Style

Alireza Kamali, Behnam Mahmodiyeh, Seyed Mohammad Jamalian, Mohadeseh Esmaeili (2021) The Effect Of Ketamine On Ventilator Isolation In Patients With Agitated Delirium In Comparison With Standard Care. Systematic Reviews in Pharmacy, 12 (3), 84-87. doi:10.31838/srp.2021.3.15





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