Abstract
Cardiovascular dysfunction is one of the most risk that has been faced human in recent time,however new drugs discovery and medicine development ,but still need to natural compound to avoid or moderate deterioration of cardiovascular ,for that researches has been set out. to display effective role of secoisolariciresinol diglucoside(SDG)against hypercholesterolemia and inflammatory cell infiltration, this work has been done. Treatment role of SDG is designed by assayed lipid profile and histopathological diagnosis of heart tissue in animals treated with high cholesterol diet (HCD).
Animal experimental
Twenty male rabbits were divided into four group, (5 rabbit for each group) administrated certain diet: negative control:Ù€normal diet for 1 month, control positive Ù€1600 mg of cholesterol with normal diet for 1 month. ,Group III - a normal diet with 1600 mg of cholesterol for 1 month then received orally with 40mg/kg/day of partial pure SDG for two weeks.
Results:
lipid profile(TC,TG,HDL,LDL) content has been found significantly increased to(1130.5, 135.3, 201.2 and 901.74 ) mg/dl respectively, after HCD (control II).on another side,has been noticed post-administrated partial pure SDG ,decreased levels of (TC,TG,HDL,LDL) to( 57,44, 43 , and 4.5) mg/dl respectively,these parameters indicated that partial pure SDG able to decrease the level of all lipid profile parameters. in addition ,observed hemorrhage coagulative necrosis with severe fatty change and inflammatory cells infiltration in heart after HCD, While animals deals with partial pure SDG did not shows any histology alteration .
Conclusion:
From our research, can conclude that partial pure SDG has been maintain lipid profile parameters normally and decreased signs of inflammation in various site of heart.

Key words: High cholesterol diet ,Lipid profile , SDG, heart fatty change.