E-ISSN 0976-2779 | ISSN 0975-8453
 

Review Article 


Crosstalk Between Sirt1 Activators And Nf-Κb Axis As A Therapeutic Target To Reduce Pancreatic Cancer

Marwah Saad Joudah, Inam Sameh Arif, Basma Talib Al-Sudani.

Abstract
The cellular availability of NAD+ is essential for Sirtuin 1 (SIRT1), a class III histone deacetylase, catalytic activity which make it as a reliable metabolic sensor. For evidence, SIRT1 had a high expression in tissue with metabolic activity including muscle, brain, liver, pancreas, and adipose tissue. Previous reports have documented the crosstalk between SIRT1 and nuclear factor kappa-B (NF-κB) signaling in conditions such as lymphoma, leukemia, and myeloma. The purpose of present study is to find the relationships between SIRT1 and NF-κB activation on pancreatic cancer cells (Capan-2, AsPC-1, and BxPC-3). We found the activation of NF-κB was inhibited by use 1 M SIRT1 aptamer by increased the activity of SIRT1 protein. Overall, our findings suggested that SIRT1 activation resulting in inhibition of pancreatic cancer cells growth and significantly repression of NF-κB proteins activation, this activation of SIRT1 by aptamer may be considered as a potential future therapy for cancer especially pancreatic cancer.

Key words: SIRT1, NF-κB p65 Transcription Factor, Pancreatic Cancer.


 
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How to Cite this Article
Pubmed Style

Marwah Saad Joudah, Inam Sameh Arif, Basma Talib Al-Sudani. Crosstalk Between Sirt1 Activators And Nf-Κb Axis As A Therapeutic Target To Reduce Pancreatic Cancer. SRP. 2021; 12(3): 207-212. doi:10.31838/srp.2021.3.34


Web Style

Marwah Saad Joudah, Inam Sameh Arif, Basma Talib Al-Sudani. Crosstalk Between Sirt1 Activators And Nf-Κb Axis As A Therapeutic Target To Reduce Pancreatic Cancer. http://www.sysrevpharm.org/?mno=51635 [Access: March 04, 2021]. doi:10.31838/srp.2021.3.34


AMA (American Medical Association) Style

Marwah Saad Joudah, Inam Sameh Arif, Basma Talib Al-Sudani. Crosstalk Between Sirt1 Activators And Nf-Κb Axis As A Therapeutic Target To Reduce Pancreatic Cancer. SRP. 2021; 12(3): 207-212. doi:10.31838/srp.2021.3.34



Vancouver/ICMJE Style

Marwah Saad Joudah, Inam Sameh Arif, Basma Talib Al-Sudani. Crosstalk Between Sirt1 Activators And Nf-Κb Axis As A Therapeutic Target To Reduce Pancreatic Cancer. SRP. (2021), [cited March 04, 2021]; 12(3): 207-212. doi:10.31838/srp.2021.3.34



Harvard Style

Marwah Saad Joudah, Inam Sameh Arif, Basma Talib Al-Sudani (2021) Crosstalk Between Sirt1 Activators And Nf-Κb Axis As A Therapeutic Target To Reduce Pancreatic Cancer. SRP, 12 (3), 207-212. doi:10.31838/srp.2021.3.34



Turabian Style

Marwah Saad Joudah, Inam Sameh Arif, Basma Talib Al-Sudani. 2021. Crosstalk Between Sirt1 Activators And Nf-Κb Axis As A Therapeutic Target To Reduce Pancreatic Cancer. Systematic Reviews in Pharmacy, 12 (3), 207-212. doi:10.31838/srp.2021.3.34



Chicago Style

Marwah Saad Joudah, Inam Sameh Arif, Basma Talib Al-Sudani. "Crosstalk Between Sirt1 Activators And Nf-Κb Axis As A Therapeutic Target To Reduce Pancreatic Cancer." Systematic Reviews in Pharmacy 12 (2021), 207-212. doi:10.31838/srp.2021.3.34



MLA (The Modern Language Association) Style

Marwah Saad Joudah, Inam Sameh Arif, Basma Talib Al-Sudani. "Crosstalk Between Sirt1 Activators And Nf-Κb Axis As A Therapeutic Target To Reduce Pancreatic Cancer." Systematic Reviews in Pharmacy 12.3 (2021), 207-212. Print. doi:10.31838/srp.2021.3.34



APA (American Psychological Association) Style

Marwah Saad Joudah, Inam Sameh Arif, Basma Talib Al-Sudani (2021) Crosstalk Between Sirt1 Activators And Nf-Κb Axis As A Therapeutic Target To Reduce Pancreatic Cancer. Systematic Reviews in Pharmacy, 12 (3), 207-212. doi:10.31838/srp.2021.3.34





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