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2021, Vol: 12, Issue: 3
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Review Article 


Synthesis And Antibacterial Evaluation Of Some New 1, 5- Benzooxazepines Derivatives

Mohammad M.Al-Tufah, Khalid A. Al-Badrany, Saad Salim Jasim.

Abstract
Ten new chalcones were prepared in three steps, firstly phthalic anhydride reacted with 4- amino acetophenone to produce 2-(4-acetyl phenyl carbamoyl) benzoic acid (M1), secondly [2-(4-acetyl phenyl carbamoyl) benzoic acid (M1)] suffers from the loss of a water molecule via reaction with (anhydrous sodium acetate and acetic anhydride) to produce 2-(4-acetyl phenyl) isoindoline-1,3-dione (M2), thirdly (M2) condensed with various substituted benzaldehydes affording chalcones (M3- M12) were reacted with 2-aminophenol to produce 1, 5- benzooxazepines compounds (M13- M22).
The prepared compounds were characterized by determination of melting point, FT-IR and some of the prepared compounds have been characterized by (1H-NMR and 13C-NMR) techniques, the antibacterial activity of some of the compounds have also been evaluated.

Key words: Chalcones, Benzoxazepines, phenylcarbamoyl, antibacterial


 
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Pubmed Style

Mohammad M.Al-Tufah, Khalid A. Al-Badrany, Saad Salim Jasim. Synthesis And Antibacterial Evaluation Of Some New 1, 5- Benzooxazepines Derivatives. SRP. 2021; 12(3): 270-285. doi:10.31838/srp.2021.3.43

Web Style

Mohammad M.Al-Tufah, Khalid A. Al-Badrany, Saad Salim Jasim. Synthesis And Antibacterial Evaluation Of Some New 1, 5- Benzooxazepines Derivatives. http://www.sysrevpharm.org/?mno=53344 [Access: March 04, 2021]. doi:10.31838/srp.2021.3.43

AMA (American Medical Association) Style

Mohammad M.Al-Tufah, Khalid A. Al-Badrany, Saad Salim Jasim. Synthesis And Antibacterial Evaluation Of Some New 1, 5- Benzooxazepines Derivatives. SRP. 2021; 12(3): 270-285. doi:10.31838/srp.2021.3.43


Vancouver/ICMJE Style

Mohammad M.Al-Tufah, Khalid A. Al-Badrany, Saad Salim Jasim. Synthesis And Antibacterial Evaluation Of Some New 1, 5- Benzooxazepines Derivatives. SRP. (2021), [cited March 04, 2021]; 12(3): 270-285. doi:10.31838/srp.2021.3.43


Harvard Style

Mohammad M.Al-Tufah, Khalid A. Al-Badrany, Saad Salim Jasim (2021) Synthesis And Antibacterial Evaluation Of Some New 1, 5- Benzooxazepines Derivatives. SRP, 12 (3), 270-285. doi:10.31838/srp.2021.3.43


Turabian Style

Mohammad M.Al-Tufah, Khalid A. Al-Badrany, Saad Salim Jasim. 2021. Synthesis And Antibacterial Evaluation Of Some New 1, 5- Benzooxazepines Derivatives. Systematic Reviews in Pharmacy, 12 (3), 270-285. doi:10.31838/srp.2021.3.43


Chicago Style

Mohammad M.Al-Tufah, Khalid A. Al-Badrany, Saad Salim Jasim. "Synthesis And Antibacterial Evaluation Of Some New 1, 5- Benzooxazepines Derivatives." Systematic Reviews in Pharmacy 12 (2021), 270-285. doi:10.31838/srp.2021.3.43


MLA (The Modern Language Association) Style

Mohammad M.Al-Tufah, Khalid A. Al-Badrany, Saad Salim Jasim. "Synthesis And Antibacterial Evaluation Of Some New 1, 5- Benzooxazepines Derivatives." Systematic Reviews in Pharmacy 12.3 (2021), 270-285. Print. doi:10.31838/srp.2021.3.43


APA (American Psychological Association) Style

Mohammad M.Al-Tufah, Khalid A. Al-Badrany, Saad Salim Jasim (2021) Synthesis And Antibacterial Evaluation Of Some New 1, 5- Benzooxazepines Derivatives. Systematic Reviews in Pharmacy, 12 (3), 270-285. doi:10.31838/srp.2021.3.43




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