E-ISSN 0976-2779 | ISSN 0975-8453
 

Review Article 


Formulation and In-Vitro Characterization of Solidified Nebivolol Self-Nanoemulsion using Liquisolid Technique

Lubna A. Sabri, Ahmed A. Hussien.

Abstract
Recently, supersaturable self-nanoemulsion (Su-SNE) is an advanced approach that can address low oral bioavailability issues. The antihypertensive drug, nebivolol (NBH), has low bioavailability, about 12%, due to its poor solubility and extensive pre-systematic metabolism. This work aimed to convert liquid nebivolol Su-SNE to powder using a liquisolid technique for exploiting the privileges of both Su-SNE and liquisolid approaches. Liquid NBH-loaded Su-SNE composed of imwitor 988, cremophor EL, propylene glycol and soluplus was adsorbed onto avicel PH101 and aerosil 200 admixture. The powder flow properties and in-vitro dissolution tests were carried out. Furthermore, the solid-state of optimized formula was characterized by SEM, DSC, X-ray diffraction, FT-IR analysis, and mean droplets size after redispersion in 0.1N HCl. The optimum liquisolid formula (SL-F8) revealed good flowability and significant dissolution improvement with 98.8% ± 0.99 drug dissolved compared to 23.1% ± 1.5 of pure NBH at 60 min. The solid-state characterization study of formula (SL-F8) showed an amorphous state of NBH within the solidified nanosystem without any interactions with the excipient used. Also, it gave nanoemulsion with mean droplets size about 47.77nm ±1.58 and PDI 0.289± 0.03, which was close to liquid Su-SNE with 55.27nm ± 1.22 droplets size and PDI 0.294± 0.01. Consequently, the liquisolid technique is a promising strategy for solidification of a liquid self-emulsifying system with improving dissolution rate and maintaining nanoemulsion properties.

Key words: Avicel PH101, dissolution efficiency, liquisolid powder, supersaturable self-nanoemulsion


 
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How to Cite this Article
Pubmed Style

Lubna A. Sabri, Ahmed A. Hussien. Formulation and In-Vitro Characterization of Solidified Nebivolol Self-Nanoemulsion using Liquisolid Technique. SRP. 2020; 11(3): 261-268. doi:10.5530/srp.2020.3.29


Web Style

Lubna A. Sabri, Ahmed A. Hussien. Formulation and In-Vitro Characterization of Solidified Nebivolol Self-Nanoemulsion using Liquisolid Technique. http://www.sysrevpharm.org//?mno=92895 [Access: March 31, 2020]. doi:10.5530/srp.2020.3.29


AMA (American Medical Association) Style

Lubna A. Sabri, Ahmed A. Hussien. Formulation and In-Vitro Characterization of Solidified Nebivolol Self-Nanoemulsion using Liquisolid Technique. SRP. 2020; 11(3): 261-268. doi:10.5530/srp.2020.3.29



Vancouver/ICMJE Style

Lubna A. Sabri, Ahmed A. Hussien. Formulation and In-Vitro Characterization of Solidified Nebivolol Self-Nanoemulsion using Liquisolid Technique. SRP. (2020), [cited March 31, 2020]; 11(3): 261-268. doi:10.5530/srp.2020.3.29



Harvard Style

Lubna A. Sabri, Ahmed A. Hussien (2020) Formulation and In-Vitro Characterization of Solidified Nebivolol Self-Nanoemulsion using Liquisolid Technique. SRP, 11 (3), 261-268. doi:10.5530/srp.2020.3.29



Turabian Style

Lubna A. Sabri, Ahmed A. Hussien. 2020. Formulation and In-Vitro Characterization of Solidified Nebivolol Self-Nanoemulsion using Liquisolid Technique. Systematic Reviews in Pharmacy, 11 (3), 261-268. doi:10.5530/srp.2020.3.29



Chicago Style

Lubna A. Sabri, Ahmed A. Hussien. "Formulation and In-Vitro Characterization of Solidified Nebivolol Self-Nanoemulsion using Liquisolid Technique." Systematic Reviews in Pharmacy 11 (2020), 261-268. doi:10.5530/srp.2020.3.29



MLA (The Modern Language Association) Style

Lubna A. Sabri, Ahmed A. Hussien. "Formulation and In-Vitro Characterization of Solidified Nebivolol Self-Nanoemulsion using Liquisolid Technique." Systematic Reviews in Pharmacy 11.3 (2020), 261-268. Print. doi:10.5530/srp.2020.3.29



APA (American Psychological Association) Style

Lubna A. Sabri, Ahmed A. Hussien (2020) Formulation and In-Vitro Characterization of Solidified Nebivolol Self-Nanoemulsion using Liquisolid Technique. Systematic Reviews in Pharmacy, 11 (3), 261-268. doi:10.5530/srp.2020.3.29





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