E-ISSN 0976-2779 | ISSN 0975-8453
 

Review Article 


The In Vitro Inhibitory Effects of Red Pomegranate (Punica granatum Linn) Extract on Fusobacterium Nucleatumís and Porphyromonas Gingivalisís Growth

Sri Hernawati, Pratiwi Soesilawati.

Abstract
Gram-negative anaerobic bacteria such as Fusobacterium nucleatum and Porphyromonas gingivalis are associated with halitosis since it can release the aroma of ammonia. Previous research has posited that flavonoids can inhibit bacterial growth. Red Pomegranate fruit is known to contain very effective flavonoids. Red pomegranate fruit is even known to contain polyphenols flavonoid and its derivatives and alkaloids. Based on this fact, Red pomegranate fruit is expected to be used as a mouthwash with anti-bacterial effect on Fusobacterium nucleatum and Porphyromonas gingivalis to control halitosis. The aim of this research was to reveal the inhibitory activity of red pomegranate extract on the growth of Fusobacterium nucleatum and Porphyromonas gingivalis by obtaining the Minimum Inhibitory Concentration (MIC) and Minimum Bactericidal Concentration (MBC). The red pomegranate extract was produced via ethanol extract to obtain 100% concentration of red pomegranate. Dilution was conducted in order to obtain extract in 100%, 50%, 25%, 12.5% and 6.25% concentration. Minimum Inhibitory Concentration (MIC) tests and Minimum Bactericidal Concentration (MBC) of pomegranate extracts against Fusobacterium nucleatum and Porphyromonas gingivalis bacteria was conducted to determine the in vitro inhibitory effect. Red pomegranate extract with a concentration of 50% is determined as a minimum inhibitory level and a minimum bacterial bacterial concentration against the growth of Fusobacterium nucleatum and Red pomegranate extracts with a concentration of 12.5% are determined as minimal inhibitory levels and Minimum Bactericidal Concentration against bacterial growth of Porphyromonas gingivalis. Red pomegranate extract had the potential to become an antibacterial agent toward the growth of Fusobacterium nucleatum and Porphyromonas gingivalis

Key words: MIC, MBC, Fusobacterium nucleatum. Porphyromonas gingivalis. Red pomegranate extract


 
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How to Cite this Article
Pubmed Style

Sri Hernawati, Pratiwi Soesilawati. The In Vitro Inhibitory Effects of Red Pomegranate (Punica granatum Linn) Extract on Fusobacterium Nucleatumís and Porphyromonas Gingivalisís Growth . SRP. 2020; 11(6): 954-959. doi:10.31838/srp.2020.6.134


Web Style

Sri Hernawati, Pratiwi Soesilawati. The In Vitro Inhibitory Effects of Red Pomegranate (Punica granatum Linn) Extract on Fusobacterium Nucleatumís and Porphyromonas Gingivalisís Growth . http://www.sysrevpharm.org//?mno=95587 [Access: July 09, 2020]. doi:10.31838/srp.2020.6.134


AMA (American Medical Association) Style

Sri Hernawati, Pratiwi Soesilawati. The In Vitro Inhibitory Effects of Red Pomegranate (Punica granatum Linn) Extract on Fusobacterium Nucleatumís and Porphyromonas Gingivalisís Growth . SRP. 2020; 11(6): 954-959. doi:10.31838/srp.2020.6.134



Vancouver/ICMJE Style

Sri Hernawati, Pratiwi Soesilawati. The In Vitro Inhibitory Effects of Red Pomegranate (Punica granatum Linn) Extract on Fusobacterium Nucleatumís and Porphyromonas Gingivalisís Growth . SRP. (2020), [cited July 09, 2020]; 11(6): 954-959. doi:10.31838/srp.2020.6.134



Harvard Style

Sri Hernawati, Pratiwi Soesilawati (2020) The In Vitro Inhibitory Effects of Red Pomegranate (Punica granatum Linn) Extract on Fusobacterium Nucleatumís and Porphyromonas Gingivalisís Growth . SRP, 11 (6), 954-959. doi:10.31838/srp.2020.6.134



Turabian Style

Sri Hernawati, Pratiwi Soesilawati. 2020. The In Vitro Inhibitory Effects of Red Pomegranate (Punica granatum Linn) Extract on Fusobacterium Nucleatumís and Porphyromonas Gingivalisís Growth . Systematic Reviews in Pharmacy, 11 (6), 954-959. doi:10.31838/srp.2020.6.134



Chicago Style

Sri Hernawati, Pratiwi Soesilawati. "The In Vitro Inhibitory Effects of Red Pomegranate (Punica granatum Linn) Extract on Fusobacterium Nucleatumís and Porphyromonas Gingivalisís Growth ." Systematic Reviews in Pharmacy 11 (2020), 954-959. doi:10.31838/srp.2020.6.134



MLA (The Modern Language Association) Style

Sri Hernawati, Pratiwi Soesilawati. "The In Vitro Inhibitory Effects of Red Pomegranate (Punica granatum Linn) Extract on Fusobacterium Nucleatumís and Porphyromonas Gingivalisís Growth ." Systematic Reviews in Pharmacy 11.6 (2020), 954-959. Print. doi:10.31838/srp.2020.6.134



APA (American Psychological Association) Style

Sri Hernawati, Pratiwi Soesilawati (2020) The In Vitro Inhibitory Effects of Red Pomegranate (Punica granatum Linn) Extract on Fusobacterium Nucleatumís and Porphyromonas Gingivalisís Growth . Systematic Reviews in Pharmacy, 11 (6), 954-959. doi:10.31838/srp.2020.6.134





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