E-ISSN 0976-2779 | ISSN 0975-8453
 

Review Article 


Hypolipidemic and Antioxidant Effects of FenugreekNigella Sativa Combination on DiabeticPatients in Iraq

Falah Hassan Shari, Hanan H. Ramadhan, Rasha N. Mohammed, Dawood CH. Al-Bahadily.

Abstract
Background: Dyslipidemia, an established risk factor for coronary heart
diseases (CHD), is the most common complication in patients with
type 2 diabetes mellitus (T2DM), many hypoglycemic drugs were used
in the management of diabetes, because of their cost and many side
effects, an alternative herbal therapeutic agent are required, from
these plants fenugreek (Trigonella foenumgraecum L) and Nigella
sativa (NS), that found to have hypolipidemic effects in the
management of type 2 diabetes mellitus and its serious complications.
This study investigates the effect of fenugreek and Nigella sativa
seeds mixture for controlling hyperglycemia, dyslipidemia and
antioxidant effect in type 2 diabetic patients.
Method: A Total of 80 patients (45 males and 35 females) with type 2
DM were recruited in this study, they were divided into two groups:
study group (n=40) given 2 g of NS seeds powder and 20 g of
fenugreek seeds powder a day for 8 weeks and Control group (n=40),
which received the usual treatment protocol, diet, exercise and oral
hypoglycemic drugs. The blood sample was collected from each
participant before and after study. Investigations include fasting blood
glucose, lipid profile test and MDA.
Result: After 2 months of treatment with fenugreek-Nigella sativa in
the study group, there was a significant difference in the total
cholesterol (195.03±8.7 vs. 247.4±9.5), low-density lipoprotein
(97.8±7.96 vs. 157.36± 6.8), Triglyceride (192±6.9 vs. 261.8±5.5) as
compared with baseline values. Although the study group showed a
significant elevation in HDL, as compared with the control group (p <
0.05) (40.85±6.16 vs. 37.15±3.18), this elevation was not significant as
compared to the baseline value (40.85±6.16 vs. 39.93±5.44). MDA in
the study group showed significant reduction as compared with its
baseline value (1.64±0.8 vs. 2.3±0.5) but this change was
nonsignificant as compared with the control group, between groups
(1.64±0.8 vs. 1.52±0.30). Fasting blood glucose were not significantly
different between the study and control groups.
Conclusion: The combination of fenugreek and Nigella Sativa herbs
have the most powerful lipid lowering effect in diabetic patients by
controlling blood glucose and its effect on dyslipideamia without side
effects and also have greater antioxidant activity by reducing the MDA
level in diabetic patients, so can be used as an alternative for
management of type 2 diabetes.

Key words: Pharmaceutialc compounds; patients; MDA level; Nigellasativa


 
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How to Cite this Article
Pubmed Style

Falah Hassan Shari, Hanan H. Ramadhan, Rasha N. Mohammed, Dawood CH. Al-Bahadily. Hypolipidemic and Antioxidant Effects of FenugreekNigella Sativa Combination on DiabeticPatients in Iraq. SRP. 2020; 11(6): 911-915. doi:10.31838srp.2020.6.128


Web Style

Falah Hassan Shari, Hanan H. Ramadhan, Rasha N. Mohammed, Dawood CH. Al-Bahadily. Hypolipidemic and Antioxidant Effects of FenugreekNigella Sativa Combination on DiabeticPatients in Iraq. http://www.sysrevpharm.org//?mno=9998 [Access: July 02, 2020]. doi:10.31838srp.2020.6.128


AMA (American Medical Association) Style

Falah Hassan Shari, Hanan H. Ramadhan, Rasha N. Mohammed, Dawood CH. Al-Bahadily. Hypolipidemic and Antioxidant Effects of FenugreekNigella Sativa Combination on DiabeticPatients in Iraq. SRP. 2020; 11(6): 911-915. doi:10.31838srp.2020.6.128



Vancouver/ICMJE Style

Falah Hassan Shari, Hanan H. Ramadhan, Rasha N. Mohammed, Dawood CH. Al-Bahadily. Hypolipidemic and Antioxidant Effects of FenugreekNigella Sativa Combination on DiabeticPatients in Iraq. SRP. (2020), [cited July 02, 2020]; 11(6): 911-915. doi:10.31838srp.2020.6.128



Harvard Style

Falah Hassan Shari, Hanan H. Ramadhan, Rasha N. Mohammed, Dawood CH. Al-Bahadily (2020) Hypolipidemic and Antioxidant Effects of FenugreekNigella Sativa Combination on DiabeticPatients in Iraq. SRP, 11 (6), 911-915. doi:10.31838srp.2020.6.128



Turabian Style

Falah Hassan Shari, Hanan H. Ramadhan, Rasha N. Mohammed, Dawood CH. Al-Bahadily. 2020. Hypolipidemic and Antioxidant Effects of FenugreekNigella Sativa Combination on DiabeticPatients in Iraq. Systematic Reviews in Pharmacy, 11 (6), 911-915. doi:10.31838srp.2020.6.128



Chicago Style

Falah Hassan Shari, Hanan H. Ramadhan, Rasha N. Mohammed, Dawood CH. Al-Bahadily. "Hypolipidemic and Antioxidant Effects of FenugreekNigella Sativa Combination on DiabeticPatients in Iraq." Systematic Reviews in Pharmacy 11 (2020), 911-915. doi:10.31838srp.2020.6.128



MLA (The Modern Language Association) Style

Falah Hassan Shari, Hanan H. Ramadhan, Rasha N. Mohammed, Dawood CH. Al-Bahadily. "Hypolipidemic and Antioxidant Effects of FenugreekNigella Sativa Combination on DiabeticPatients in Iraq." Systematic Reviews in Pharmacy 11.6 (2020), 911-915. Print. doi:10.31838srp.2020.6.128



APA (American Psychological Association) Style

Falah Hassan Shari, Hanan H. Ramadhan, Rasha N. Mohammed, Dawood CH. Al-Bahadily (2020) Hypolipidemic and Antioxidant Effects of FenugreekNigella Sativa Combination on DiabeticPatients in Iraq. Systematic Reviews in Pharmacy, 11 (6), 911-915. doi:10.31838srp.2020.6.128





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