Near-Infrared Spectroscopy for Nondestructive Evaluation of Tablets

Systematic Reviews in Pharmacy,2010,1,1,17-23.
Published:Jan, 2010
Type:Invited Review

Near-Infrared Spectroscopy for Nondestructive Evaluation of Tablets

Javed Ali, Pramod K, SH Ansari1

Departments of Pharmaceutics and 1Pharmacognosy and Phytochemistry, Faculty of Pharmacy, Jamia Hamdard, Hamdard Nagar, New Delhi, India

Abstract:

A nondestructive evaluation of tablets is possible with the application of near-infrared spectroscopy and appropriate statistical techniques. Tablet hardness, disintegration time, dissolution, drug and excipient content, particle size, identification of actives and/or excipients, etc. are possible with the help of near-infrared spectroscopy. The established methods using this technique are rapid and simple. The technique also has found its place in quality assurance and quality control of tablets. It has been suggested as a useful method for the real time in-process testing and is a valuable process analytical technology tool.