Applications of Co-Crystals in Pharmaceutical Drugs

Systematic Reviews in Pharmacy,2018,9,1,55-57.
Published:December 2017
Type:Review article

Applications of Co-Crystals in Pharmaceutical Drugs

Mikal Rekdal1, Aravind Pai3, Ravi Choudhari2, Muddukrishna Badamane Sathyanarayana2*

1Department of Chemical Engineering, Norwegian University of Science and Technology, Trondheim, NORWAY.

2Department of Pharmaceutical Quality Assurance, Manipal College of Pharmaceutical Sciences, Manipal Academy of Higher Education, Manipal, Karnataka, INDIA.

3Department of Pharmaceutical Chemistry, Manipal College of Pharmaceutical Sciences, Manipal Academy of Higher Education, Manipal, Karnataka, INDIA.

Abstract:

Co-crystal synthesis has become a field of high interest in the last decade. This category of solid forms has a variety of applications in industries such as textile, paper and electronics. For many purposes co-crystals will have superior properties in comparison to traditional salt crystals. This review article will focus on the application of co-crystals in pharmaceutical drugs. Co-crystals have opened doors to rein-troduce previously poor performing bioactive ingredients in new and improved solid structures. They have also allowed for the introduction of a new range of compounds for pharmaceutical therapy. Most importantly, co-crystals can create new medicines with increased solubility and hence improve the effi-ciency and safety of the treatment.