Nitrogen Containing Secondary Metabolites from Endophytes of Medicinal Plants and their Biological/Pharmacological Activities- A Review
Endophytes are the microbes that live inside of a plant and colonise the intercellular spaces of the plant tissues. Nitrogen containing compounds have an important role in research through decades as a history in the development of organic synthesis. Nitrogen is a part of all living cells and an important component of all proteins, enzymes, nucleic acids, cofactors, signalling molecules, numerous plant secondary products and necessary metabolic processes involved in the synthesis and transfer of energy. These compounds also occur in a diverse natural products and drugs showing importance in many aspects of life and commercial processes. A nitrogenous secondary metabolite obtained by endophytes originate from various biosynthetic pathways belonging to different structural groups such as alkaloids, amines, peptides, etc. These secondary metabolites show promising potentiality and benefits in safety and human health. This review covers diversity of nitrogenous secondary metabolites isolated from endophytes associated with medicinal plants possessing biological/pharmacological activities such as anticancer, antimicrobial, antifungal, antiviral, antimalarial, etc in the plant tissues from years 2008-2016.