Interpretation of Full Scan Atmospheric Pressure Ionization Mass Spectra (MS) and Collision Induced Dissociation Fragmentation Spectra (MS/MS) of Small Organic Molecules – A Mini Review

Submitted by system on Tue, 10/03/2017 - 02:50
Systematic Reviews in Pharmacy,2017,9,1,XX-XX.
Published:October 2017
Type:Review Article

Interpretation of Full Scan Atmospheric Pressure Ionization Mass Spectra (MS) and Collision Induced Dissociation Fragmentation Spectra (MS/MS) of Small Organic Molecules – A Mini Review

Dev Kant Shandilya1*,Peter Edward Joseph2, Venkata Siva Satyanarayana Kantamreddi3

1Department of Research, Bhagwant University, Ajmer, Rajasthan, INDIA.

2Department of Chemistry, St. John’s College, Agra, Uttar Pradesh, INDIA.

.3Centre for Chemical Analysis, Central Research Laboratory (CRL), GIT, GITAM University, Visakhapatnam, INDIA.

Abstract:

The potential of mass spectrometry (MS) is often not fully utilized due to the absence of systematic workflow of mass spectral interpretation, partially caused by the lack of simplified literature for interpretation of soft ionization methods and collision induced fragmentation spectral data interpretation. Therefore, this review summarizes the rational work flows for the interpretation of mass spectral data generated using atmospheric pressure ionization (API) and collision induced dissociation (CID) fragmentation. Designed workflow will definitely assist the readers to interpret MS and MS/MS spectral data, especially for the structural elucidation of small drug molecules and their impurities.

Images: 
Reference table for applying for even-odd electron fragments