A Systematic Review on Pharmacological Activities of 4-Methylumbelliferon

Submitted by system on Fri, 12/22/2017 - 05:05
Systematic Reviews in Pharmacy,2018,9,1,49-54.
Published:December 2017
Type:Review Article

A Systematic Review on Pharmacological Activities of 4-Methylumbelliferon

Yasmeen Al-Majedy1, Abdul Amir Kadhum2, Hiba Ibraheem1, Ahmed Al-Amiery1*, Ahmed Abdel Moneim3, Abu Bakar Mohamad2

1Branch of Chemistry, Department of Applied Science, University of Technology (UOT), Baghdad 10001, IRAQ.

2Department of Chemical and Process Engineering, Universiti Kebangsaan Malaysia (UKM), Bangi, Selangor, MALAYSIA.

3Department of Zoology and Entomology, Faculty of Science Helwan University, Cairo, EGYPT.

Abstract:

Umbelliferon, the natural crenelated coumarin distributed in the plants of a piaceae family, has shown various biological activities, especially as a cancer chemo preventive agent. Coumarins have been categorized as a member of family of benzo-pyrone, that consist of pyrone ring united to benzene ring. The benzo-pyrones may be sectioned to alfa type that coumarins belong and the gama type that flavonoids have been major members. Coumarins are chemical entity which has being synthesized in the past few years many forms of its derivatives; the entity provides the principal origin of motivating to numerous chemist to investigate its diverse medical efforts especially with regards to the anticoagulant activity. In present article we review recent 4-Methylumbelliferon, (4-MU) that are synthesized with it pharmacological activities antioxidant, anti-inflammatory, antimicrobial activity, ant hepatitis, hepatoprotective, anticancer, antipyretic and analgesic activity.

Images: 
Molnar and Čačić synthesized a series of coumarins (1, 2, 3, and 4) and have been investigated for antioxidant activities.