Pulsatile Delivery Systems: An Approach for Chronotherapeutic Diseases

Systematic Reviews in Pharmacy,2010,1,1,55-61.
Published:Jan, 2010
Type:Review Article

Pulsatile Delivery Systems: An Approach for Chronotherapeutic Diseases

Shidhaye SS, Lotlikar VM1, Ghule AM1, Phutane PK1, Kadam VJ1

Department of Pharmaceutics, Vivekanand Education Society’s College of Pharmacy, Behind Collector Colony, Chembur (E), Mumbai - 400 074, 1Department of Pharmaceutics, Bharati Vidyapeeth’s College of Pharmacy, University of Mumbai, Sector 8, CBD Belapur, Navi Mumbai - 400 614, India


Delivery systems with a pulsatile release pattern are receiving a sprouting attraction for the development of drugs for which conventional controlled-release systems with a continuous release are not ideal. Most physiological, biochemical, and molecular processes in healthy organisms display robust, predictable changes on a 24-h schedule. Chronotherapeutic products can synchronize drug delivery with circadian rhythms in order to optimize efficacy and/or minimize side effects. These products follow a sigmoidal release profile characterized by a time period of no release (lag time) followed by a rapid and complete drug release. Various capsular, osmotic, single and multiple unit systems are based on the use of soluble/erodible polymer coatings, rupturable membranes, and membrane permeabilities. Marketed technologies such as PULSYS, CODAS®, TIMERx®, and DIFFUCAPS® follow one of the above mechanisms to render a sigmoidal drug release profile. So these systems are tuned according to body’s circadian clock having a potential to improve quality of patients life undergoing conventional drug therapy.