Stomach-Specific Mucoadhesive Microsphere as a Controlled Drug Delivery System

Systematic Reviews in Pharmacy,2010,1,1,70-78.
Published:Jan, 2010
Type:Review Article

Stomach-Specific Mucoadhesive Microsphere as a Controlled Drug Delivery System

Rajput G, Majmudar F1, Patel J, Thakor R, Rajgor NB2

Department of Pharmaceutics, Nootan Pharmacy College, Visnagar - 384 315, 1N.H.L Municipal Medical College, Ahmedabad, 2Department of Pharmaceutics, M.P. Patel College of Pharmacy, Jeevanshilp Education Campus, Gharod Road, Kapadwanj, Gujarat - 387 620, India

Abstract:

Stomach-specific mucoadhesive microspheres as a controlled drug delivery system have been developed to increase gastric retention time of the dosage forms. It is known that differences in gastric physiology, such as gastric pH and motility, exhibit both intra- as well as inter-subject variability demonstrating significant impact on gastric retention time and drug delivery behavior. This article presents the polymers use for mucoadhesive microsphere, factor affecting the mucoadhesion, and preparation techniques of mucoadhesive microsphere. Developments in the techniques for in vitro and in vivo evaluation of mucoadhesive microspheres have also been discussed.