A Clinical Update on Peroxisome Proliferator-Activated Receptors

Systematic Reviews in Pharmacy,2010,1,2,175-181.
Published:Jan, 2010
Type:Review Article

A Clinical Update on Peroxisome Proliferator-Activated Receptors

Kumar A, Hasamnis A1

Unit of Pharmacology, Faculty of Medicine, Malaysia, 1Faculty of Medicine, AIMST University, Malaysia


The peroxisome proliferator-activated receptors (PPARs) belong to the group of nuclear receptor superfamily. There are three subtypes of these receptors, PPAR alpha, beta, and gamma. These receptors display differential tissue distribution and have specific functions. PPARs mainly regulate lipid and carbohydrate metabolism. These receptors are also involved in inflammatory process, reproduction, carcinogenesis, and other physiological processes in the body. Modulation of these receptors has wide therapeutic potential in diseases like diabetes mellitus, obesity, heart disease, atherosclerosis, cancer, inflammatory bowel disease, and many other conditions. In the last few decades, numerous agonists and antagonists of PPARs have been discovered some of which are now used in therapeutics. This review focuses mainly on the role of PPARs and their ligands under different clinical conditions.