A New Generation of 7-Chloro-4-Aminoquinoline Antimalarials

Systematic Reviews in Pharmacy,2010,1,2,182-189.
Published:Jan, 2010
Type:Review Article

A New Generation of 7-Chloro-4-Aminoquinoline Antimalarials

Singh V, Tyagi L, Singhal M1, Sharma CS2, Kori ML3

Department of Pharmaceutical Chemistry, Geetanjali College of Pharmaceutical Studies, Udaipur, Rajasthan, 1Jaipur National University, Jaipur, Rajasthan, 2B. N. P. G. College, Udaipur, Rajasthan, 3IES School of Pharmacy, Bhopal, Madhya Pradesh, India



There is an urgent need to find new and cost-effective drug molecules for the treatment of malaria due to the rapid spread of resistance toward currently available drugs. Records of malaria date back to the earliest human civilizations when it was described as the distinct periodic fevers. Malaria is a serious infection with Plasmodium parasites, which are spread by the bite of Anopheles mosquitoes. For this reason, nearly all malaria control strategies target either the parasite or the mosquito. In spite of worldwide efforts, however, an eradication of malaria is far from being achieved. There are no fewer than 4 species of Plasmodium that infect people, each with thousands of genetic variants, and about —35 different species of malaria-transmitting mosquitoes. It is the complex diversity of the parasites, the mosquitoes, the local ecologies, socioeconomic conditions, and human responses to disease that conspire to make malaria notoriously hard to control. There is no single prescription which can successfully control malaria in all areas. Plasmodium falciparum is generally slow to develop resistance to the 4-aminoquinoline-containing drug. Antimalarial drug resistance is worsening, with the geographic spread of resistance widening to previously unaffected areas and a remorseless increase both in the prevalence and degree of drug resistance. The unavoidable spread of drug resistance and until the development of an effective antimalarial vaccine, the search for effective, safe, and affordable drugs for falciparum malaria is one of the most pressing health priorities worldwide. This article reviews the newly synthesized 7-chloro-4-aminoquinolines as effective antimalarial agents.