Particle Size Enlargement: Making and Understanding of the Behavior of Powder (Particle) System

Systematic Reviews in Pharmacy,2011,2,2,79-85.
Published:Jan, 2011
Type:Review Article

Particle Size Enlargement: Making and Understanding of the Behavior of Powder (Particle) System

Kale VV, Gadekar S, Ittadwar AM

Department of Pharmaceutics, Gurunanak College of Pharmacy, Dixit Nagar, Nari, Nagpur- 440 026, India

Abstract:

Particle size enlargement is the process of transforming fine particles into larger particles by the introduction of external forces, and is a value-added step in many processes involving powdered materials. There are many different reasons to enlarge particle size, including increased flowability and improved product shape and appearance. With the multitude of options available to achieve enlarged particle product, it can be difficult to narrow down the best method for the desired application. The main factor in selecting the right kind of method is to specify the type of end product required. In the pharmaceutical industry in particular, uniform flow of solid mixtures is one of the most important considerations in solid dosage manufacture. The particle size distribution, shape, hardness, and moisture content of the powder particles govern its flow and compactibility property. This article outlines making of enlarged particles and understanding their behavior.